Fourie Joubert

A structural annotation resource for the selection of putative target proteins in the malaria parasite (2008)

Joubert, Yolandi, Joubert, Fourie

Abstract Background Protein structure plays a pivotal role in elucidating mechanisms of parasite functioning and drug resistance. Moreover, protein structure aids the determination of protein...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2008)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2008)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2008)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

MADIBA: A web server toolkit for biological interpretation of Plasmodium and plant gene clusters (2008)

Law, Philip J, Claudel-Renard, Clotilde, Joubert, Fourie, Louw, Abraham I, Berger, Dave K

Abstract Background Microarray technology makes it possible to identify changes in gene expression of an organism, under various conditions. Data mining is thus essential for deducing significant...

Influence of Sutherlandia frutescens extracts on cell numbers, morphology and gene expression in MCF-7 cells (2007)

Stander, B.A., Marais, Sumari, Steynberg, T.J., Theron, D., Joubert, Fourie, Albrecht, C., ...

Sutherlandia frutescens is a well-known South African herbal remedy traditionally used for stomach problems, internal cancers, diabetes, various inflammatory conditions and recently to improve the...

Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase (2007)

Burger, Pieter Buys, Birkholtz, Lyn-Marie, Joubert, Fourie, Haider, Nashya, Walter, Rolf D., Louw, Abraham I.

Spermidine synthase is currently considered as a promising drug target in the malaria parasite, Plasmodium falciparum, due to the vital role of spermidine in the activation of the eukaryotic...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2006)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

Abstract The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a...

Influence of prostaglandin A2 on Bax, Bcl-2 and PCNA expression in MCF-7 cells (2006)

Joubert, Annie, Bianchi, Pepita, Maritz, Christine, Joubert, Fourie

The effects of 20 μg/mL exogenous prostaglandin A2 (PGA2) were determined on Bax, Bcl-2 and proliferating cell nuclear antigen (PCNA) expression levels in MCF-7 cells. Flow cytometric analysis...

Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase–dihydropteroate synthase (2006)

Louw, Abraham I., Joubert, Fourie

Resistance of the most virulent human malaria parasite, Plasmodium falciparum, to antifolates is spreading with increasing speed, especially in Africa. Antifolate resistance is mainly caused by point...

Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells (2005)

Joubert, Annie, Maritz, Christine, Joubert, Fourie

2-Methoxyestradiol (2ME), an endogenous metabolite of 17Beta-estradiol, has been reported to play an active role in the induction of apoptosis in both proliferating endothelial and cancer cells....

Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells (2005)

Joubert, Annie, Maritz, Christine, Joubert, Fourie

Proteins of the Bcl-2 family are key regulators of apoptosis. Bax can be regarded as pro-apoptotic, whereas Bcl-2 is perceived as anti-apoptotic. It has been proposed that an increased ratio of...

The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number

Collins, Nicola E., Liebenberg, Junita, De Villiers, Etienne P., Brayton, Kelly A., Louw, Elmarié, Pretorius, Alri, ...

Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to...

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

Birkholtz, Lyn-Marie, Wrenger, Carsten, Joubert, Fourie, Wells, Gordon A, Walter, Rolf D, Louw, Abraham I

Polyamine biosynthesis of the malaria parasite, Plasmodium falciparum, is regulated by a single, hinge-linked bifunctional PfAdoMetDC/ODC [ P. falciparum AdoMetDC (S-adenosylmethionine...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number

Collins, Nicola E., Liebenberg, Junita, De Villiers, Etienne P., Brayton, Kelly A., Louw, Elmarié, Pretorius, Alri, ...

Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to...

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

Birkholtz, Lyn-Marie, Wrenger, Carsten, Joubert, Fourie, Wells, Gordon A, Walter, Rolf D, Louw, Abraham I

Polyamine biosynthesis of the malaria parasite, Plasmodium falciparum, is regulated by a single, hinge-linked bifunctional PfAdoMetDC/ODC [ P. falciparum AdoMetDC (S-adenosylmethionine...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...