Cohuet, Anna, Krishnakumar, Sujatha, Simard, Frédéric, Morlais, Isabelle, Koutsos, Anastasios, Fontenille, Didier, ...
Abstract Background Anopheles innate immunity affects Plasmodium development and is a potential target of innovative malaria control strategies. The extent and distribution of nucleotide diversity in...
Mapping and identification of essential gene functions on the X chromosome of Drosophila (2002)
Peter, Annette, Schoettler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
Benos, Panayiotis V., Gatt, Melanie K., Murphy, Lee, Harris, David, Barrell, Bart, Ferraz, Concepcion, ...
We present the sequence of a contiguous 2.63 Mb of DNA extending from the tip of the X chromosome of Drosophila melanogaster. Within this sequence, we predict 277 protein coding genes, of which 94...
Shen, Zhicheng, Dimopoulos, George, Kafatos, Fotis C., Jacobs-Lorena, Marcelo
An invertebrate intestinal mucin gene, AgMuc1, was isolated from the malaria vector mosquito Anopheles gambiae. The predicted 122-residue protein consists of a central core of seven repeating TTTTVAP...
Silkmoth chorion proteins: Sequence analysis of the products of a multigene family (1978)
Regier, Jerome C., Kafatos, Fotis C., Goodfliesh, Robert, Hood, Leroy
Five polypeptide components have been isolated from the eggshell (chorion) of a silkmoth. Two are homogeneous on sodium dodecyl sulfate and isoelectric focusing gels, and three contain predominantly...
Thesis (Ph. D.)--Harvard University, 1965.
The chemical defense mechanisms of millipedes. (1961)
Thesis (B.A.)--Cornell University.
Toward Anopheles transformation: Minos element activity in anopheline cells and embryos
Catteruccia, Flaminia, Nolan, Tony, Blass, Claudia, Müller, Hans-Michael, Crisanti, Andrea, Kafatos, Fotis C., ...
The ability of the Minos transposable element to function as a transformation vector in anopheline mosquitoes was assessed. Two recently established Anopheles gambiae cell lines were stably...
Danielli, Alberto, Loukeris, Thanasis G., Lagueux, Marie, Müller, Hans-Michael, Richman, Adam, Kafatos, Fotis C.
Sp22D, a modular serine protease encompassing chitin binding, low density lipoprotein receptor, and scavenger receptor cysteine-rich domains, was identified by molecular cloning in the malaria...
Dimopoulos, George, Casavant, Thomas L., Chang, Shereen, Scheetz, Todd, Roberts, Chad, Donohue, Micca, ...
Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite...
A cell surface mucin specifically expressed in the midgut of the malaria mosquito Anopheles gambiae
Shen, Zhicheng, Dimopoulos, George, Kafatos, Fotis C., Jacobs-Lorena, Marcelo
An invertebrate intestinal mucin gene, AgMuc1, was isolated from the malaria vector mosquito Anopheles gambiae. The predicted 122-residue protein consists of a central core of seven repeating TTTTVAP...
Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites
Dimopoulos, George, Richman, Adam, Müller, Hans-Michael, Kafatos, Fotis C.
Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker...
Wang, Rui, Zheng, Liangbiao, Touré, Yeya T., Dandekar, Thomas, Kafatos, Fotis C.
Genetic distance measurements are an important tool to differentiate field populations of disease vectors such as the mosquito vectors of malaria. Here, we have measured the genetic differentiation...
Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George
A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...
Thomasová, Dana, Ton, Lucas Q., Copley, Richard R., Zdobnov, Evgeny M., Wang, Xuelan, Hong, Young S., ...
We have sequenced six overlapping clones from a library of bacterial artificial chromosome (BAC) clones derived from a laboratory strain of the mosquito, Anopheles gambiae, the major vector of human...
Dimopoulos, George, Christophides, George K., Meister, Stephan, Schultz, Jörg, White, Kevin P., Barillas-Mury, Carolina, ...
The complex gene expression responses of Anopheles gambiae to microbial and malaria challenges, injury, and oxidative stress (in the mosquito and/or a cultured cell line) were surveyed by using cDNA...
The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae
Kumar, Sanjeev, Christophides, George K., Cantera, Rafael, Charles, Bradley, Han, Yeon Soo, Meister, Stephan, ...
Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected refractory strain of Anopheles gambiae blocks...
Han, Yeon Soo, Thompson, Joanne, Kafatos, Fotis C., Barillas-Mury, Carolina
We present a detailed analysis of the interactions between Anopheles stephensi midgut epithelial cells and Plasmodium berghei ookinetes during invasion of the mosquito by the parasite. In this...
Benos, Panayiotis V., Gatt, Melanie K., Murphy, Lee, Harris, David, Barrell, Bart, Ferraz, Concepcion, ...
We present the sequence of a contiguous 2.63 Mb of DNA extending from the tip of the X chromosome of Drosophila melanogaster. Within this sequence, we predict 277 protein coding genes, of which 94...
Purification of a Family of Specific Messenger Ribonucleic Acids from Moth Follicular Cells
Gelinas, Richard E., Kafatos, Fotis C.
When moth follicular cells synthesize the characteristic, low-molecular-weight chorion (eggshell) proteins, they contain at least two groups of 8-9S RNAs which appear to be chorion mRNA. This class...
Mapping and identification of essential gene functions on the X chromosome of Drosophila
Peter, Annette, Schöttler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene
Blandin, Stéphanie, Moita, Luis F., Köcher, Thomas, Wilm, Matthias, Kafatos, Fotis C., Levashina, Elena A.
Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector–parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA)...
Belyakin, Stepan N., Christophides, George K., Alekseyenko, Artyom A., Kriventseva, Evgenia V., Belyaeva, Elena S., Nanayev, Roman A., ...
In Drosophila polytene chromosomes, most late-replicating regions remain underreplicated. A loss-of-function mutant of the suppressor of underreplication [Su(UR)] gene suppresses underreplication...
Meister, Stephan, Kanzok, Stefan M., Zheng, Xue-li, Luna, Coralia, Li, Tong-Ruei, Hoa, Ngo T., ...
We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-κB-like transcription factor orthologous to Drosophila Relish. Through alternative...
Bolshakov, Viacheslav N., Topalis, Pantelis, Blass, Claudia, Kokoza, Elena, Della Torre, Alessandra, Kafatos, Fotis C., ...
Genome evolution entails changes in the DNA sequence of genes and intergenic regions, changes in gene numbers, and also changes in gene order along the chromosomes. Genes are reshuffled by...
AnoEST: Toward A. gambiae functional genomics
Kriventseva, Evgenia V., Koutsos, Anastasios C., Blass, Claudia, Kafatos, Fotis C., Christophides, George K., Zdobnov, Evgeny M.
Here, we present an analysis of 215,634 EST and cDNA sequences of a major vector of human malaria Anopheles gambiae structured into the AnoEST database. The expressed sequences are grouped into...
An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites
Abraham, Eappen G., Pinto, Sofia B., Ghosh, Anil, Vanlandingham, Dana L., Budd, Aidan, Higgs, Stephen, ...
We have functionally analyzed the orthologous SRPN6 genes from Anopheles stephensi and Anopheles gambiae using phylogenetic, molecular, reverse genetic, and cell biological tools. The results...
Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei
Michel, Kristin, Budd, Aidan, Pinto, Sofia, Gibson, Toby J, Kafatos, Fotis C
We report on a phylogenetic and functional analysis of genes encoding three mosquito serpins (SRPN1, SRPN2 and SRPN3), which resemble known inhibitors of prophenoloxidase-activating enzymes in other...
Komitopoulou, Katia, Gans, Madeleine, Margaritis, Lukas H., Kafatos, Fotis C., Masson, Michele
To study genes that function mainly or exclusively during oogenesis, we have isolated and analyzed female-sterile mutations, with special emphasis on those that affect eggshell formation. Following...
Conditional expression in the malaria mosquito Anopheles stephensi with Tet-On and Tet-Off systems.
Lycett, Gareth J, Kafatos, Fotis C, Loukeris, Thanasis G
We report successful conditional gene expression in the malaria vector, Anopheles stephensi, on the basis of binary systems consisting of gene driver and responder transgenic lines generated by...
Toward Anopheles transformation: Minos element activity in anopheline cells and embryos
Catteruccia, Flaminia, Nolan, Tony, Blass, Claudia, Müller, Hans-Michael, Crisanti, Andrea, Kafatos, Fotis C., ...
The ability of the Minos transposable element to function as a transformation vector in anopheline mosquitoes was assessed. Two recently established Anopheles gambiae cell lines were stably...
Danielli, Alberto, Loukeris, Thanasis G., Lagueux, Marie, Müller, Hans-Michael, Richman, Adam, Kafatos, Fotis C.
Sp22D, a modular serine protease encompassing chitin binding, low density lipoprotein receptor, and scavenger receptor cysteine-rich domains, was identified by molecular cloning in the malaria...
Dimopoulos, George, Casavant, Thomas L., Chang, Shereen, Scheetz, Todd, Roberts, Chad, Donohue, Micca, ...
Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite...
A cell surface mucin specifically expressed in the midgut of the malaria mosquito Anopheles gambiae
Shen, Zhicheng, Dimopoulos, George, Kafatos, Fotis C., Jacobs-Lorena, Marcelo
An invertebrate intestinal mucin gene, AgMuc1, was isolated from the malaria vector mosquito Anopheles gambiae. The predicted 122-residue protein consists of a central core of seven repeating TTTTVAP...
Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites
Dimopoulos, George, Richman, Adam, Müller, Hans-Michael, Kafatos, Fotis C.
Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker...
Wang, Rui, Zheng, Liangbiao, Touré, Yeya T., Dandekar, Thomas, Kafatos, Fotis C.
Genetic distance measurements are an important tool to differentiate field populations of disease vectors such as the mosquito vectors of malaria. Here, we have measured the genetic differentiation...
Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George
A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...
Thomasová, Dana, Ton, Lucas Q., Copley, Richard R., Zdobnov, Evgeny M., Wang, Xuelan, Hong, Young S., ...
We have sequenced six overlapping clones from a library of bacterial artificial chromosome (BAC) clones derived from a laboratory strain of the mosquito, Anopheles gambiae, the major vector of human...
Dimopoulos, George, Christophides, George K., Meister, Stephan, Schultz, Jörg, White, Kevin P., Barillas-Mury, Carolina, ...
The complex gene expression responses of Anopheles gambiae to microbial and malaria challenges, injury, and oxidative stress (in the mosquito and/or a cultured cell line) were surveyed by using cDNA...
Bolshakov, Viacheslav N., Topalis, Pantelis, Blass, Claudia, Kokoza, Elena, Della Torre, Alessandra, Kafatos, Fotis C., ...
Genome evolution entails changes in the DNA sequence of genes and intergenic regions, changes in gene numbers, and also changes in gene order along the chromosomes. Genes are reshuffled by...
The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae
Kumar, Sanjeev, Christophides, George K., Cantera, Rafael, Charles, Bradley, Han, Yeon Soo, Meister, Stephan, ...
Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected refractory strain of Anopheles gambiae blocks...
Han, Yeon Soo, Thompson, Joanne, Kafatos, Fotis C., Barillas-Mury, Carolina
We present a detailed analysis of the interactions between Anopheles stephensi midgut epithelial cells and Plasmodium berghei ookinetes during invasion of the mosquito by the parasite. In this...
Benos, Panayiotis V., Gatt, Melanie K., Murphy, Lee, Harris, David, Barrell, Bart, Ferraz, Concepcion, ...
We present the sequence of a contiguous 2.63 Mb of DNA extending from the tip of the X chromosome of Drosophila melanogaster. Within this sequence, we predict 277 protein coding genes, of which 94...
Purification of a Family of Specific Messenger Ribonucleic Acids from Moth Follicular Cells
Gelinas, Richard E., Kafatos, Fotis C.
When moth follicular cells synthesize the characteristic, low-molecular-weight chorion (eggshell) proteins, they contain at least two groups of 8-9S RNAs which appear to be chorion mRNA. This class...
Mapping and identification of essential gene functions on the X chromosome of Drosophila
Peter, Annette, Schöttler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene
Blandin, Stéphanie, Moita, Luis F., Köcher, Thomas, Wilm, Matthias, Kafatos, Fotis C., Levashina, Elena A.
Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector–parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA)...
AnoEST: Toward A. gambiae functional genomics
Kriventseva, Evgenia V., Koutsos, Anastasios C., Blass, Claudia, Kafatos, Fotis C., Christophides, George K., Zdobnov, Evgeny M.
Here, we present an analysis of 215,634 EST and cDNA sequences of a major vector of human malaria Anopheles gambiae structured into the AnoEST database. The expressed sequences are grouped into...
Belyakin, Stepan N., Christophides, George K., Alekseyenko, Artyom A., Kriventseva, Evgenia V., Belyaeva, Elena S., Nanayev, Roman A., ...
In Drosophila polytene chromosomes, most late-replicating regions remain underreplicated. A loss-of-function mutant of the suppressor of underreplication [Su(UR)] gene suppresses underreplication...
Meister, Stephan, Kanzok, Stefan M., Zheng, Xue-li, Luna, Coralia, Li, Tong-Ruei, Hoa, Ngo T., ...
We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-κB-like transcription factor orthologous to Drosophila Relish. Through alternative...
Komitopoulou, Katia, Gans, Madeleine, Margaritis, Lukas H., Kafatos, Fotis C., Masson, Michele
To study genes that function mainly or exclusively during oogenesis, we have isolated and analyzed female-sterile mutations, with special emphasis on those that affect eggshell formation. Following...
An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites
Abraham, Eappen G., Pinto, Sofia B., Ghosh, Anil, Vanlandingham, Dana L., Budd, Aidan, Higgs, Stephen, ...
We have functionally analyzed the orthologous SRPN6 genes from Anopheles stephensi and Anopheles gambiae using phylogenetic, molecular, reverse genetic, and cell biological tools. The results...
Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei
Michel, Kristin, Budd, Aidan, Pinto, Sofia, Gibson, Toby J, Kafatos, Fotis C
We report on a phylogenetic and functional analysis of genes encoding three mosquito serpins (SRPN1, SRPN2 and SRPN3), which resemble known inhibitors of prophenoloxidase-activating enzymes in other...
Conditional expression in the malaria mosquito Anopheles stephensi with Tet-On and Tet-Off systems.
Lycett, Gareth J, Kafatos, Fotis C, Loukeris, Thanasis G
We report successful conditional gene expression in the malaria vector, Anopheles stephensi, on the basis of binary systems consisting of gene driver and responder transgenic lines generated by...
VectorBase: a home for invertebrate vectors of human pathogens
Lawson, Daniel, Arensburger, Peter, Atkinson, Peter, Besansky, Nora J., Bruggner, Robert V., Butler, Ryan, ...
VectorBase () is a web-accessible data repository for information about invertebrate vectors of human pathogens. VectorBase annotates and maintains vector genomes providing an integrated resource for...
Michel, Kristin, Suwanchaichinda, Chansak, Morlais, Isabelle, Lambrechts, Louis, Cohuet, Anna, Awono-Ambene, Parfait H., ...
Serpins are central to the modulation of various innate immune responses in insects and are suspected to influence the outcome of malaria parasite infection in mosquito vectors. Three Anopheles...
Ecker, Andrea, Pinto, Sofia B., Baker, Ken W., Kafatos, Fotis C., Sinden, Robert E.
During its life cycle the malarial parasite Plasmodium forms three invasive stages which have to invade different and specific cells for replication to ensue. Invasion is vital to parasite survival...
Mosaic Genome Architecture of the Anopheles gambiae Species Complex
Wang-Sattler, Rui, Blandin, Stephanie, Ning, Ye, Blass, Claudia, Dolo, Guimogo, Touré, Yeya T., ...
Anopheles and Plasmodium: from laboratory models to natural systems in the field
Cohuet, Anna, Osta, Mike A, Morlais, Isabelle, Awono-Ambene, Parfait H, Michel, Kristin, Simard, Frederic, ...
Parasites that cause malaria must complete a complex life cycle in Anopheles vector mosquitoes in order to be transmitted from human to human. Previous gene-silencing studies have shown the influence...
Koutsos, Anastasios C., Blass, Claudia, Meister, Stephan, Schmidt, Sabine, MacCallum, Robert M., Soares, Marcelo B., ...
The African mosquito Anopheles gambiae is the major vector of human malaria. We report a genome-wide survey of mosquito gene expression profiles clustered temporally into developmental programs and...