Florenci Serras

Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila (2008)

Blanco, Enrique, Pignatelli, Miguel, Beltran, Sergi, Punset, Adrià, Pérez-Lluch, Silvia, Serras, Florenci, ...

Abstract Background The trithorax group (trxG) and Polycomb group (PcG) proteins are responsible for the maintenance of stable transcriptional patterns of many developmental regulators. They bind to...

Functional dissection of the ash2and ash1transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions (2007)

Beltran, Sergi, Angulo, Mireia, Pignatelli, Miguel, Serras, Florenci, Corominas, Montserrat

Abstract Background The trithorax group (trxG) genes absent , small or homeotic discs 1 ( ash1 ) and 2 ( ash2 ) were isolated in a screen for mutants with abnormal imaginal discs. Mutations in either...

Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster

Beltran, Sergi, Blanco, Enrique, Serras, Florenci, Pérez-Villamil, Beatriz, Guigó, Roderic, Artavanis-Tsakonas, Spyros, ...

The transcription factor absent, small, or homeotic discs 2 (ash2) gene is a member of the trithorax group of positive regulators of homeotic genes. Mutant alleles for ash2 are larval/pupal lethals...

Fusion of the Human Gene for the Polyubiquitination Coeffector UEV1 with Kua, a Newly Identified Gene

Thomson, Timothy M., Lozano, Juan José, Loukili, Noureddine, Carrió, Roberto, Serras, Florenci, Cormand, Bru, ...

UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV is part of the...

In silico identification of novel selenoproteins in the Drosophila melanogaster genome

Castellano, Sergi, Morozova, Nadya, Morey, Marta, Berry, Marla J., Serras, Florenci, Corominas, Montserrat, ...

In selenoproteins, incorporation of the amino acid selenocysteine is specified by the UGA codon, usually a stop signal. The alternative decoding of UGA is conferred by an mRNA structure, the SECIS...

The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster.

Ryder, Edward, Blows, Fiona, Ashburner, Michael, Bautista-Llacer, Rosa, Coulson, Darin, Drummond, Jenny, ...

We describe a collection of P-element insertions that have considerable utility for generating custom chromosomal aberrations in Drosophila melanogaster. We have mobilized a pair of engineered P...

Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions

Beltran, Sergi, Angulo, Mireia, Pignatelli, Miguel, Serras, Florenci, Corominas, Montserrat

Analysis of the gene expression profiles of wing imaginal discs from ash2 and ash1 mutants shows that they are highly similar, supporting a model in which they act together to maintain stable states...

The DrosDel Deletion Collection: A Drosophila Genomewide Chromosomal Deficiency Resource

Ryder, Edward, Ashburner, Michael, Bautista-Llacer, Rosa, Drummond, Jenny, Webster, Jane, Johnson, Glynnis, ...

We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering ∼77% of the Release 5.1 genome. Using a...