A Family of Stability Determinants in Pathogenic Bacteria
A novel segregational stability system was identified on plasmid R485, which originates from Morganella morganii. The system is composed of two overlapping genes, stbD and stbE, which potentially...
Identification of XcpZ Domains Required for Assembly of the Secreton of Pseudomonas aeruginosa
Robert, Viviane, Hayes, Finbarr, Lazdunski, Andrée, Michel, Gérard P. F.
Most of the exoproteins secreted by Pseudomonas aeruginosa are transported via the type II secretion system. This machinery, which is widely conserved in gram-negative bacteria, consists of 12 Xcp...
Hayes, Finbarr, Caplice, Elizabeth, McSweeney, Anne, Fitzgerald, Gerald F., Daly, Charles
A combination of plasmid curing and DNA-DNA hybridization data facilitated the identification of proteinase plasmids of 75 (pCI301) and 35 kilobases (pCI203) in the multi-plasmid-containing strains...
Identification of the Minimal Replicon of Lactococcus lactis subsp. lactis UC317 Plasmid pCI305
Hayes, Finbarr, Daly, Charles, Fitzgerald, Gerald F.
Replication functions of the stable, cryptic 8.7-kilobase (kb) plasmid pCI305 from multi-plasmid-containing Lactococcus lactis subsp. lactis UC317 were studied. Analysis of this replicon was...
Protein Diversity Confers Specificity in Plasmid Segregation
Fothergill, Timothy J. G., Barillà, Daniela, Hayes, Finbarr
The ParG segregation protein (8.6 kDa) of multidrug resistance plasmid TP228 is a homodimeric DNA-binding factor. The ParG dimer consists of intertwined C-terminal domains that adopt a...
Bacterial DNA segregation dynamics mediated by the polymerizing protein ParF
Barillà, Daniela, Rosenberg, Mark F, Nobbmann, Ulf, Hayes, Finbarr
Prokaryotic DNA segregation most commonly involves members of the Walker-type ParA superfamily. Here we show that the ParF partition protein specified by the TP228 plasmid is a ParA ATPase that...
A Family of Stability Determinants in Pathogenic Bacteria
A novel segregational stability system was identified on plasmid R485, which originates from Morganella morganii. The system is composed of two overlapping genes, stbD and stbE, which potentially...
Identification of XcpZ Domains Required for Assembly of the Secreton of Pseudomonas aeruginosa
Robert, Viviane, Hayes, Finbarr, Lazdunski, Andrée, Michel, Gérard P. F.
Most of the exoproteins secreted by Pseudomonas aeruginosa are transported via the type II secretion system. This machinery, which is widely conserved in gram-negative bacteria, consists of 12 Xcp...
Hayes, Finbarr, Caplice, Elizabeth, McSweeney, Anne, Fitzgerald, Gerald F., Daly, Charles
A combination of plasmid curing and DNA-DNA hybridization data facilitated the identification of proteinase plasmids of 75 (pCI301) and 35 kilobases (pCI203) in the multi-plasmid-containing strains...
Identification of the Minimal Replicon of Lactococcus lactis subsp. lactis UC317 Plasmid pCI305
Hayes, Finbarr, Daly, Charles, Fitzgerald, Gerald F.
Replication functions of the stable, cryptic 8.7-kilobase (kb) plasmid pCI305 from multi-plasmid-containing Lactococcus lactis subsp. lactis UC317 were studied. Analysis of this replicon was...
Protein Diversity Confers Specificity in Plasmid Segregation
Fothergill, Timothy J. G., Barillà, Daniela, Hayes, Finbarr
The ParG segregation protein (8.6 kDa) of multidrug resistance plasmid TP228 is a homodimeric DNA-binding factor. The ParG dimer consists of intertwined C-terminal domains that adopt a...
Bacterial DNA segregation dynamics mediated by the polymerizing protein ParF
Barillà, Daniela, Rosenberg, Mark F, Nobbmann, Ulf, Hayes, Finbarr
Prokaryotic DNA segregation most commonly involves members of the Walker-type ParA superfamily. Here we show that the ParF partition protein specified by the TP228 plasmid is a ParA ATPase that...
Kędzierska, Barbara, Lian, Lu-Yun, Hayes, Finbarr
Toxin–antitoxin (TA) complexes function in programmed cell death or stress response mechanisms in bacteria. The YefM–YoeB TA complex of Escherichia coli consists of YoeB toxin that is...
Barillà, Daniela, Carmelo, Emma, Hayes, Finbarr
The ParF protein of plasmid TP228 belongs to the ubiquitous superfamily of ParA ATPases that drive DNA segregation in bacteria. ATP-bound ParF polymerizes into multistranded filaments. The partner...
Centromere anatomy in the multidrug-resistant pathogen Enterococcus faecium
Derome, Andrew, Hoischen, Christian, Bussiek, Malte, Grady, Ruth, Adamczyk, Malgorzata, Kędzierska, Barbara, ...
Multidrug-resistant variants of the opportunistic human pathogen Enterococcus have recently emerged as leading agents of nosocomial infection. The acquisition of plasmid-borne resistance genes is a...
Kulinska, Anna, Czeredys, Magdalena, Hayes, Finbarr, Jagura-Burdzy, Grazyna
IncU plasmids are a distinctive group of mobile elements with highly conserved backbone functions and variable antibiotic resistance gene cassettes. The IncU archetype is conjugative plasmid RA3,...