Evangelia D. Chrysina

Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs

Oikonomakos, Nikos G., Kosmopoulou, Magda N., Chrysina, Evangelia D., Leonidas, Demetres D., Kostas, Ioannis D., Wendt, K. Ulrich, ...

Acyl ureas were discovered as a novel class of inhibitors for glycogen phosphorylase, a molecular target to control hyperglycemia in type 2 diabetics. This series is exemplified by 6-{2,6-Dichloro-...

Kinetic and crystallographic studies on 2-(β-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site

Chrysina, Evangelia D., Kosmopoulou, Magda N., Tiraidis, Constantinos, Kardakaris, Rozina, Bischler, Nicolas, Leonidas, Demetres D., ...

In an attempt to identify leads that would enable the design of inhibitors with enhanced affinity for glycogen phosphorylase (GP), that might control hyperglycaemia in type 2 diabetes, three new...

The binding of β- and γ-cyclodextrins to glycogen phosphorylase b: Kinetic and crystallographic studies

Pinotsis, Nikos, Leonidas, Demetres D., Chrysina, Evangelia D., Oikonomakos, Nikos G., Mavridis, Irene M.

A number of regulatory binding sites of glycogen phosphorylase (GP), such as the catalytic, the inhibitor, and the new allosteric sites are currently under investigation as targets for inhibition of...

High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors

Leonidas, Demetres D., Chavali, Gayatri B., Oikonomakos, Nikos G., Chrysina, Evangelia D., Kosmopoulou, Magda N., Vlassi, Metaxia, ...

The crystal structures of bovine pancreatic ribonuclease A (RNase A) in complex with 3′,5′-ADP, 2′,5′-ADP, 5′-ADP, U-2′-p and U-3′-p have been determined at high resolution. The...

Role of conserved residues in structure and stability: Tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily

Greene, Lesley H., Chrysina, Evangelia D., Irons, Laurence I., Papageorgiou, Anastassios C., Acharya, K. Ravi, Brew, Keith

Serum retinol binding protein (RBP) is a member of the lipocalin family, proteins with up-and-down β-barrel folds, low levels of sequence identity, and diverse functions. Although tryptophan 24 of...