Hypoxia Links ATR and p53 through Replication Arrest
Hammond, Ester M., Denko, Nicholas C., Dorie, Mary Jo, Abraham, Robert T., Giaccia, Amato J.
Previous studies have demonstrated that phosphorylation of human p53 on serine 15 contributes to protein stabilization after DNA damage and that this is mediated by the ATM family of kinases....
DNA Damage during Reoxygenation Elicits a Chk2-Dependent Checkpoint Response
Freiberg, Rachel A., Hammond, Ester M., Dorie, Mary Jo, Welford, Scott M., Giaccia, Amato J.
Due to the abnormal vasculature of solid tumors, tumor cell oxygenation can change rapidly with the opening and closing of blood vessels, leading to the activation of both hypoxic response pathways...
Genome-Wide Analysis of p53 under Hypoxic Conditionsâ€
Hammond, Ester M., Mandell, Daniel J., Salim, Ali, Krieg, Adam J., Johnson, Thomas M., Shirazi, Haider A., ...
Hypoxia is an important nongenotoxic stress that modulates the tumor suppressor activity of p53 during malignant progression. In this study, we investigated how genotoxic and nongenotoxic stresses...
Hypoxia Links ATR and p53 through Replication Arrest
Hammond, Ester M., Denko, Nicholas C., Dorie, Mary Jo, Abraham, Robert T., Giaccia, Amato J.
Previous studies have demonstrated that phosphorylation of human p53 on serine 15 contributes to protein stabilization after DNA damage and that this is mediated by the ATM family of kinases....
DNA Damage during Reoxygenation Elicits a Chk2-Dependent Checkpoint Response
Freiberg, Rachel A., Hammond, Ester M., Dorie, Mary Jo, Welford, Scott M., Giaccia, Amato J.
Due to the abnormal vasculature of solid tumors, tumor cell oxygenation can change rapidly with the opening and closing of blood vessels, leading to the activation of both hypoxic response pathways...
Genome-Wide Analysis of p53 under Hypoxic Conditionsâ€
Hammond, Ester M., Mandell, Daniel J., Salim, Ali, Krieg, Adam J., Johnson, Thomas M., Shirazi, Haider A., ...
Hypoxia is an important nongenotoxic stress that modulates the tumor suppressor activity of p53 during malignant progression. In this study, we investigated how genotoxic and nongenotoxic stresses...
Functional Analysis of p53 Binding under Differential Stressesâ€
Krieg, Adam J., Hammond, Ester M., Giaccia, Amato J.
Hypoxia and DNA damage stabilize the p53 protein, but the subsequent effect that each stress has on transcriptional regulation of known p53 target genes is variable. We have used chromatin...