An empirical evaluation of the common disease-common variant hypothesis (2007)
Chen, Gary K, Jorgenson, Eric, Witte, John S
Abstract While genome-wide linkage studies have been successful in mapping variants underlying rare monogenic disorders, genome-wide association studies may be more appropriate for detecting common...
Hierarchical modeling in association studies of multiple phenotypes (2005)
Liu, Xin, Jorgenson, Eric, Witte, John S
Abstract The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex...
Ethnicity and Human Genetic Linkage Maps (2005)
Jorgenson, Eric, Tang, Hua, Gadde, Maya, Province, Mike, Leppert, Mark, Kardia, Sharon, ...
Human genetic linkage maps are based on rates of recombination across the genome. These rates in humans vary by the sex of the parent from whom alleles are inherited, by chromosomal position, and by...
Genetic analysis of human quantitative traits / (2004)
Jorgenson, Eric., Risch, Neil Advisor
Submitted to the Department of Genetics.
Genetic variation in aldosterone synthase predicts plasma glucose levels
Ranade, Koustubh, Wu, Kwan Dun, Risch, Neil, Olivier, Michael, Pei, Dee, Hsiao, Chin-Fu, ...
The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between single-nucleotide polymorphisms in...
Coverage and Power in Genomewide Association Studies
Jorgenson, Eric, Witte, John S.
The ability of genomewide association studies to decipher genetic traits is driven in part by how well the measured single-nucleotide polymorphisms “cover” the unmeasured causal variants....
Genetic variation in aldosterone synthase predicts plasma glucose levels
Ranade, Koustubh, Wu, Kwan Dun, Risch, Neil, Olivier, Michael, Pei, Dee, Hsiao, Chin-Fu, ...
The mineralocorticoid hormone, aldosterone, is known to play a role in sodium homeostasis. We serendipitously found, however, highly significant association between single-nucleotide polymorphisms in...
A Polymorphism in the β1 Adrenergic Receptor Is Associated with Resting Heart Rate
Ranade, Koustubh, Jorgenson, Eric, Sheu, Wayne H.-H., Pei, Dee, Hsiung, Chao Agnes, Chiang, Fu-tien, ...
Resting heart rate is significantly associated with cardiovascular morbidity and mortality. However, the extent to which resting heart rate is genetically determined is poorly understood, and no...
Ethnicity and Human Genetic Linkage Maps
Jorgenson, Eric, Tang, Hua, Gadde, Maya, Province, Mike, Leppert, Mark, Kardia, Sharon, ...
Human genetic linkage maps are based on rates of recombination across the genome. These rates in humans vary by the sex of the parent from whom alleles are inherited, by chromosomal position, and by...
Coverage and Power in Genomewide Association Studies
Jorgenson, Eric, Witte, John S.
The ability of genomewide association studies to decipher genetic traits is driven in part by how well the measured single-nucleotide polymorphisms “cover” the unmeasured causal variants....
Hierarchical modeling in association studies of multiple phenotypes
Liu, Xin, Jorgenson, Eric, Witte, John S
The genetic study of disease-associated phenotypes has become common because such phenotypes are often easier to measure and in many cases are under greater genetic control than the complex disease...
An empirical evaluation of the common disease-common variant hypothesis
Chen, Gary K, Jorgenson, Eric, Witte, John S
While genome-wide linkage studies have been successful in mapping variants underlying rare monogenic disorders, genome-wide association studies may be more appropriate for detecting common variants...