Eric Ghigo

Coxiella burnetii Survives in Monocytes from Patients with Q Fever Endocarditis: Involvement of Tumor Necrosis Factor

Dellacasagrande, Jérôme, Ghigo, Eric, Capo, Christian, Raoult, Didier, Mege, Jean-Louis

Endocarditis is the most frequent form of chronic Q fever, an infectious disease caused by Coxiella burnetii. As this obligate intracellular bacterium inhabits monocytes and macrophages, we wondered...

Interleukin-10 Stimulates Coxiella burnetii Replication in Human Monocytes through Tumor Necrosis Factor Down-Modulation: Role in Microbicidal Defect of Q Fever

Ghigo, Eric, Capo, Christian, Raoult, Didier, Mege, Jean-Louis

Coxiella burnetii, an obligate intracellular bacterium, is the agent of Q fever. The chronic form of the disease is associated with the overproduction of interleukin-10 and deficient C. burnetii...

αvβ3 Integrin and Bacterial Lipopolysaccharide Are Involved in Coxiella burnetii-Stimulated Production of Tumor Necrosis Factor by Human Monocytes

Dellacasagrande, Jérôme, Ghigo, Eric, Machergui-El , Sarah, Toman, Rudolf, Raoult, Didier, ...

Coxiella burnetii, the agent of Q fever, enters human monocytes through αvβ3 integrin and survives inside host cells. In addition, C. burnetii stimulates the synthesis of inflammatory cytokines...

Survival of Tropheryma whipplei, the Agent of Whipple's Disease, Requires Phagosome Acidification

Ghigo, Eric, Capo, Christian, Aurouze, Marianne, Tung, Ching-Hsuan, Gorvel, Jean-Pierre, Raoult, Didier, ...

Tropheryma whipplei was established as the agent of Whipple's disease in 2000, but the mechanisms by which it survives within host cells are still unknown. We show here that T. whipplei survives...

Coxiella burnetii Survives in Monocytes from Patients with Q Fever Endocarditis: Involvement of Tumor Necrosis Factor

Dellacasagrande, Jérôme, Ghigo, Eric, Capo, Christian, Raoult, Didier, Mege, Jean-Louis

Endocarditis is the most frequent form of chronic Q fever, an infectious disease caused by Coxiella burnetii. As this obligate intracellular bacterium inhabits monocytes and macrophages, we wondered...

Interleukin-10 Stimulates Coxiella burnetii Replication in Human Monocytes through Tumor Necrosis Factor Down-Modulation: Role in Microbicidal Defect of Q Fever

Ghigo, Eric, Capo, Christian, Raoult, Didier, Mege, Jean-Louis

Coxiella burnetii, an obligate intracellular bacterium, is the agent of Q fever. The chronic form of the disease is associated with the overproduction of interleukin-10 and deficient C. burnetii...

αvβ3 Integrin and Bacterial Lipopolysaccharide Are Involved in Coxiella burnetii-Stimulated Production of Tumor Necrosis Factor by Human Monocytes

Dellacasagrande, Jérôme, Ghigo, Eric, Machergui-El , Sarah, Toman, Rudolf, Raoult, Didier, ...

Coxiella burnetii, the agent of Q fever, enters human monocytes through αvβ3 integrin and survives inside host cells. In addition, C. burnetii stimulates the synthesis of inflammatory cytokines...

Survival of Tropheryma whipplei, the Agent of Whipple's Disease, Requires Phagosome Acidification

Ghigo, Eric, Capo, Christian, Aurouze, Marianne, Tung, Ching-Hsuan, Gorvel, Jean-Pierre, Raoult, Didier, ...

Tropheryma whipplei was established as the agent of Whipple's disease in 2000, but the mechanisms by which it survives within host cells are still unknown. We show here that T. whipplei survives...

The Uptake of Apoptotic Cells Drives Coxiella burnetii Replication and Macrophage Polarization: A Model for Q Fever Endocarditis

Benoit, Marie, Ghigo, Eric, Capo, Christian, Raoult, Didier, Mege, Jean-Louis

Patients with valvulopathy have the highest risk to develop infective endocarditis (IE), although the relationship between valvulopathy and IE is not clearly understood. Q fever endocarditis, an IE...

Ameobal Pathogen Mimivirus Infects Macrophages through Phagocytosis

Ghigo, Eric, Kartenbeck, Jürgen, Lien, Pham, Pelkmans, Lucas, Capo, Christian, Mege, Jean-Louis, ...

Mimivirus, or Acanthamoeba polyphaga mimivirus (APMV), a giant double-stranded DNA virus that grows in amoeba, was identified for the first time in 2003. Entry by phagocytosis within amoeba has been...