Eric Deprez

Structures et rôles de l’intégrase du VIH dans le cycle viral (2008)

Mouscadet, Jean-François, Tchertanov, Luba, Deprez, Eric

L’intégrase rétrovirale est responsable de l’intégration de l’ADN du VIH1 dans l’ADN cellulaire, processus indispensable à la réplication virale. Le processus d’intégration se déroule en...

Structures et rôles de l’intégrase du VIH dans le cycle viral (2008)

Mouscadet, Jean-François, Tchertanov, Luba, Deprez, Eric

L’intégrase rétrovirale est responsable de l’intégration de l’ADN du VIH1 dans l’ADN cellulaire, processus indispensable à la réplication virale. Le processus d’intégration se déroule en...

Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase. (2008)

Delelis, Olivier, Parissi, Vincent, Leh, Hervé, Mbemba, Gladys, Petit, Caroline, Sonigo, Pierre, ...

BACKGROUND: HIV-1 integrase (IN) catalyses the retroviral integration process, removing two nucleotides from each long terminal repeat and inserting the processed viral DNA into the target DNA. It is...

Efficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase. (2008)

Delelis, Olivier, Parissi, Vincent, Leh, Hervé, Mbemba, Gladys, Petit, Caroline, Sonigo, Pierre, ...

BACKGROUND: HIV-1 integrase (IN) catalyses the retroviral integration process, removing two nucleotides from each long terminal repeat and inserting the processed viral DNA into the target DNA. It is...

DNA binding induces dissociation of the multimeric form of HIV-1 integrase: A time-resolved fluorescence anisotropy study

Deprez, Eric, Tauc, Patrick, Leh, Hervé, Mouscadet, Jean-François, Auclair, Christian, Hawkins, Mary E., ...

Self-assembly of HIV-1 integrase (IN) in solution has been studied previously by time-resolved fluorescence, using tryptophan anisotropy decay. This approach provides information on the size of...

A Subunit of Yeast TFIIIC Participates in the Recruitment of TATA-Binding Protein

Deprez, Eric, Arrebola, Rosalía, Conesa, Christine, Sentenac, André

TFIIIC plays a key role in nucleating the assembly of the initiation factor TFIIIB on class III genes. We have characterized an essential gene, TFC8, encoding the 60-kDa polypeptide, τ60, present in...

Disulfide-Linked Integrase Oligomers Involving C280 Residues Are Formed In Vitro and In Vivo but Are Not Essential for Human Immunodeficiency Virus Replication

Bischerour, Julien, Leh, Hervé, Deprez, Eric, Brochon, Jean-Claude, Mouscadet, Jean-François

The human immunodeficiency virus type 1 integrase (IN) forms an oligomer that integrates both ends of the viral DNA. The nature of the active oligomer is unclear. Recombinant IN obtained under...

Styrylquinolines, Integrase Inhibitors Acting Prior to Integration: a New Mechanism of Action for Anti-Integrase Agents

Bonnenfant, Sabine, Thomas, Claire Marie, Vita, Claudio, Subra, Frédéric, Deprez, Eric, Zouhiri, Fatima, ...

We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of...

Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles

Ishchenko, Alexander A., Deprez, Eric, Maksimenko, Andrei, Brochon, Jean-Claude, Tauc, Patrick, Saparbaev, Murat K.

The multifunctional DNA repair enzymes apurinic/apyrimidinic (AP) endonucleases cleave DNA at AP sites and 3′-blocking moieties generated by DNA glycosylases in the base excision repair pathway....

DNA binding induces dissociation of the multimeric form of HIV-1 integrase: A time-resolved fluorescence anisotropy study

Deprez, Eric, Tauc, Patrick, Leh, Hervé, Mouscadet, Jean-François, Auclair, Christian, Hawkins, Mary E., ...

Self-assembly of HIV-1 integrase (IN) in solution has been studied previously by time-resolved fluorescence, using tryptophan anisotropy decay. This approach provides information on the size of...

A Subunit of Yeast TFIIIC Participates in the Recruitment of TATA-Binding Protein

Deprez, Eric, Arrebola, Rosalía, Conesa, Christine, Sentenac, André

TFIIIC plays a key role in nucleating the assembly of the initiation factor TFIIIB on class III genes. We have characterized an essential gene, TFC8, encoding the 60-kDa polypeptide, τ60, present in...

Disulfide-Linked Integrase Oligomers Involving C280 Residues Are Formed In Vitro and In Vivo but Are Not Essential for Human Immunodeficiency Virus Replication

Bischerour, Julien, Leh, Hervé, Deprez, Eric, Brochon, Jean-Claude, Mouscadet, Jean-François

The human immunodeficiency virus type 1 integrase (IN) forms an oligomer that integrates both ends of the viral DNA. The nature of the active oligomer is unclear. Recombinant IN obtained under...

Styrylquinolines, Integrase Inhibitors Acting Prior to Integration: a New Mechanism of Action for Anti-Integrase Agents

Bonnenfant, Sabine, Thomas, Claire Marie, Vita, Claudio, Subra, Frédéric, Deprez, Eric, Zouhiri, Fatima, ...

We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of...

Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles

Ishchenko, Alexander A., Deprez, Eric, Maksimenko, Andrei, Brochon, Jean-Claude, Tauc, Patrick, Saparbaev, Murat K.

The multifunctional DNA repair enzymes apurinic/apyrimidinic (AP) endonucleases cleave DNA at AP sites and 3′-blocking moieties generated by DNA glycosylases in the base excision repair pathway....

Efficient and Specific Internal Cleavage of a Retroviral Palindromic DNA Sequence by Tetrameric HIV-1 Integrase

Delelis, Olivier, Parissi, Vincent, Leh, Hervé, Mbemba, Gladys, Petit, Caroline, Sonigo, Pierre, ...