Amplification and overexpression of Neu (HER2, ErbB2) has been observed in a significant proportion of human breast cancers. Consistent with this, overexpression of various neu alleles in the mammary...
Andrechek, Eran R., Muller, William J.
In human breast cancer, 20 to 30% of human breast cancers amplify and overexpress the Neu proto-oncogene. To fully elucidate the role of this gene in normal development and breast cancer, we have...
Andrechek, Eran R., Muller, William
Breast cancer is a prevalent, yet poorly understood disease. Of the women afflicted with breast cancer, 20-30 % of cases contain amplified and overexpressed ErbB2 (Neu, HER2). In order to examine the...
Thesis (Ph.D.)--McMaster University, 2003.
Andrechek, Eran R, Muller, William J
Abstract The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal...
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
Andrechek, Eran R., Hardy, William R., Siegel, Peter M., Rudnicki, Michael A., Cardiff, Robert D., Muller, William J.
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20–30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of...
Rauh, Michael J., Blackmore, Valerie, Andrechek, Eran R., Tortorice, Christopher G., Daly, Roger, Lai, Venus Ka-Man, ...
The Grb2 and Shc adapter proteins play critical roles in coupling activated growth factor receptors to several cellular signaling pathways. To assess the role of these molecules in mammary epithelial...
ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival
Andrechek, Eran R., Hardy, William R., Girgis-Gabardo, Adele A., Perry, Robert L. S., Butler, Richard, Graham, Frank L., ...
Signaling mediated by ErbB2 is thought to play a critical role in numerous developmental processes. However, due to the embryonic lethality associated with the germ line inactivation of erbB2, its...
Andrechek, Eran R, Muller, William J
The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal...
Andrechek, Eran R., Hardy, William R., Laing, Michael A., Muller, William J.
We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary...
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
Andrechek, Eran R., Hardy, William R., Siegel, Peter M., Rudnicki, Michael A., Cardiff, Robert D., Muller, William J.
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20–30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of...
Rauh, Michael J., Blackmore, Valerie, Andrechek, Eran R., Tortorice, Christopher G., Daly, Roger, Lai, Venus Ka-Man, ...
The Grb2 and Shc adapter proteins play critical roles in coupling activated growth factor receptors to several cellular signaling pathways. To assess the role of these molecules in mammary epithelial...
ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival
Andrechek, Eran R., Hardy, William R., Girgis-Gabardo, Adele A., Perry, Robert L. S., Butler, Richard, Graham, Frank L., ...
Signaling mediated by ErbB2 is thought to play a critical role in numerous developmental processes. However, due to the embryonic lethality associated with the germ line inactivation of erbB2, its...
Andrechek, Eran R, Muller, William J
The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal...
Andrechek, Eran R., Hardy, William R., Laing, Michael A., Muller, William J.
We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary...
Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia
Giangrande, Paloma H., Zhang, JianXin, Tanner, Alice, Eckhart, Andrea D., Rempel, Rachel E., Andrechek, Eran R., ...
Intimal hyperplasia (IH) and restenosis limit the long-term utility of bypass surgery and angioplasty due to pathological proliferation and migration of vascular smooth muscle cells (VSMCs) into the...