Emmanuel Ségéral

ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCP Ubiquitin Ligase

Lassot, Irina, Ségéral, Emmanuel, Berlioz-Torrent, Clarisse, Durand, Herve, Groussin, Lionel, Hai, Tsonwin, ...

The ubiquitin-proteasome pathway regulates gene expression through protein degradation. Here we show that the F-box protein βTrCP, the receptor component of the SCF E3 ubiquitin ligase responsible...

ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCP Ubiquitin Ligase

Lassot, Irina, Ségéral, Emmanuel, Berlioz-Torrent, Clarisse, Durand, Herve, Groussin, Lionel, Hai, Tsonwin, ...

The ubiquitin-proteasome pathway regulates gene expression through protein degradation. Here we show that the F-box protein βTrCP, the receptor component of the SCF E3 ubiquitin ligase responsible...

von Hippel–Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step

Mousnier, Aurélie, Kubat, Nicole, Massias-Simon, Aurélie, Ségéral, Emmanuel, Rain, Jean-Christophe, Benarous, Richard, ...

HIV-1 integrase, the viral enzyme responsible for provirus integration into the host genome, can be actively degraded by the ubiquitin–proteasome pathway. Here, we identify von Hippel–Lindau...