Alaez, Carmen, Lin, Ling, Flores-A, Hilario, Vazquez, Miriam, Munguia, Andrea, Mignot, Emmanuel, ...
Abstract Background Narcolepsy-cataplexy is characterized by excessive daytime sleepiness with recurrent episodes of irresistible sleep, cataplexy, hallucinations and sleep paralysis. Its aetiology...
Eriksson, Krister S, Zhang, Shengwen, Lin, Ling, Larivière, Roxanne C, Julien, Jean-Pierre, Mignot, Emmanuel
Abstract Background Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with...
Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants (2007)
Tohei Yokogawa, Wilfredo Marin, Juliette Faraco, Guillaume Pézeron, Lior Appelbaum, Jian Zhang, ...
Sleep is a fundamental biological process conserved across the animal kingdom. The study of how sleep regulatory networks are conserved is needed to better understand sleep across evolution. We...
Reduced expression of TAC1, PENKand SOCS2in Hcrtr-2mutated narcoleptic dog brain (2007)
Lindberg, Julia, Saetre, Peter, Nishino, Seiji, Mignot, Emmanuel, Jazin, Elena
Abstract Background Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin...
Polymorphisms within the canine MLPHgene are associated with dilute coat color in dogs (2005)
Philipp, Ute, Hamann, Henning, Mecklenburg, Lars, Nishino, Seiji, Mignot, Emmanuel, Günzel-Apel, Anne-Rose, ...
Abstract Background Pinschers and other dogs with coat color dilution show a characteristic pigmentation phenotype. The fur colors are a lighter shade, e.g. silvery grey (blue) instead of black and a...
Shahrad Taheri, Ling Lin, Diane Austin, Terry Young, Emmanuel Mignot
The less people sleep the higher their risk for being overweight. This study shows that sleep duration affects appetite-regulating hormones.
Shahrad Taheri, Ling Lin, Diane Austin, Terry Young, Emmanuel Mignot
Background Sleep duration may be an important regulator of body weight and metabolism. An association between short habitual sleep time and increased body mass index (BMI) has been reported in large...
Mignot, Emmanuel, Lin, Ling, Rogers, William, Honda, Yutaka, Qiu, Xiaohong, Lin, Xiaoyan, ...
Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602. Few studies have investigated the influence...
HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy (1997)
Aldrich, Michael S., Hetisimer, A. H., Hansen, Sherry L., Ellis, Michael C., McClelland, Erin, Quintana, Leah, ...
A systematic haplotype and sequencing analysis of the HLA -DR and - DQ region in patients with narcolepsy was performed. Five new (CA) n microsatellite markers were generated and positioned on the...
PRAZOSIN CONTRAINDICATED IN PATIENTS WITH NARCOLEPSY (1988)
Guilleminault, Christian, Mignot, Emmanuel, Aldrich, Michael S., Quera-Salva, Maria-Antonia, Tiberge, Michel, Partinen, Markku
Peer Reviewed
Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence
Jin, Li, Macaubas, Claudia, Hallmayer, Joachim, Kimura, Akinori, Mignot, Emmanuel
The understanding of the mutational mechanism that generates high levels of variation at microsatellite loci lags far behind the application of these genetic markers. A phylogenetic approach was...
The Complex Mutation Pattern of a Microsatellite
Macaubas, Claudia, Jin, Li, Hallmayer, Joachim, Kimura, Akinori, Mignot, Emmanuel
DQCAR is a (CA)n microsatellite located in the HLA class II region and tightly linked to HLA–DQB1. Previous studies showed a strikingly low level of size variation in DQCAR alleles within an...
Taheri, Shahrad, Lin, Ling, Austin, Diane, Young, Terry, Mignot, Emmanuel
The less people sleep the higher their risk for being overweight. This study shows that sleep duration affects appetite-regulating hormones
Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs
Philipp, Ute, Hamann, Henning, Mecklenburg, Lars, Nishino, Seiji, Mignot, Emmanuel, Günzel-Apel, Anne-Rose, ...
The Diurnal Rhythm of Hypocretin in Young and Old F344 Rats
Desarnaud, Frank, Murillo-Rodriguez, Eric, Lin, Ling, Xu, Man, Gerashchenko, Dmitry, Shiromani, Samara N., ...
Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups
Mignot, Emmanuel, Lin, Ling, Rogers, William, Honda, Yutaka, Qiu, Xiaohong, Lin, Xiaoyan, ...
Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602. Few studies have investigated the influence...
Zeitzer, Jamie M, Buckmaster, Christine L, Lyons, David M, Mignot, Emmanuel
The hypocretin system is involved in the integration of hypothalamic functions with sleep and wake. Hypocretin-1 release peaks at the end of the active period in both diurnal and nocturnal species. A...
Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence
Jin, Li, Macaubas, Claudia, Hallmayer, Joachim, Kimura, Akinori, Mignot, Emmanuel
The understanding of the mutational mechanism that generates high levels of variation at microsatellite loci lags far behind the application of these genetic markers. A phylogenetic approach was...
The Complex Mutation Pattern of a Microsatellite
Macaubas, Claudia, Jin, Li, Hallmayer, Joachim, Kimura, Akinori, Mignot, Emmanuel
DQCAR is a (CA)n microsatellite located in the HLA class II region and tightly linked to HLA–DQB1. Previous studies showed a strikingly low level of size variation in DQCAR alleles within an...
Taheri, Shahrad, Lin, Ling, Austin, Diane, Young, Terry, Mignot, Emmanuel
The less people sleep the higher their risk for being overweight. This study shows that sleep duration affects appetite-regulating hormones
Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans
Oksenberg, Jorge R., Barcellos, Lisa F., Cree, Bruce A. C., Baranzini, Sergio E., Bugawan, Teodorica L., Khan, Omar, ...
An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an association with the HLA-DRB1*1501-DQB1*0602 haplotype has been repeatedly demonstrated in high-risk (northern...
Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs
Philipp, Ute, Hamann, Henning, Mecklenburg, Lars, Nishino, Seiji, Mignot, Emmanuel, Günzel-Apel, Anne-Rose, ...
Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups
Mignot, Emmanuel, Lin, Ling, Rogers, William, Honda, Yutaka, Qiu, Xiaohong, Lin, Xiaoyan, ...
Human narcolepsy-cataplexy, a sleep disorder associated with a centrally mediated hypocretin (orexin) deficiency, is tightly associated with HLA-DQB1*0602. Few studies have investigated the influence...
Zeitzer, Jamie M, Buckmaster, Christine L, Lyons, David M, Mignot, Emmanuel
The hypocretin system is involved in the integration of hypothalamic functions with sleep and wake. Hypocretin-1 release peaks at the end of the active period in both diurnal and nocturnal species. A...
Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain
Lindberg, Julia, Saetre, Peter, Nishino, Seiji, Mignot, Emmanuel, Jazin, Elena
Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants
Yokogawa, Tohei, Marin, Wilfredo, Faraco, Juliette, Pézeron, Guillaume, Appelbaum, Lior, Zhang, Jian, ...
Sleep is a fundamental biological process conserved across the animal kingdom. The study of how sleep regulatory networks are conserved is needed to better understand sleep across evolution. We...
The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse
Eriksson, Krister S, Zhang, Shengwen, Lin, Ling, Larivière, Roxanne C, Julien, Jean-Pierre, Mignot, Emmanuel
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
Zhang, Shengwen, Zeitzer, Jamie M, Sakurai, Takeshi, Nishino, Seiji, Mignot, Emmanuel
Recent population studies have identified important interrelationships between sleep duration and body weight regulation. The hypothalamic hypocretin/orexin neuropeptide system is able to influence...