Versatile and Antique World of RNA : The Simplicity of RNA Mediated Catalysis (2007)
RNA is the only biological molecule that can function both as a repository of information and as a catalyst. This, together with the ability to self-replicate, led to recognition of RNA as ‘prelude...
Versatile and Antique World of RNA : The Simplicity of RNA Mediated Catalysis (2007)
RNA is the only biological molecule that can function both as a repository of information and as a catalyst. This, together with the ability to self-replicate, led to recognition of RNA as ‘prelude...
Cross talk between the +73/294 interaction and the cleavage site in RNase P RNA mediated cleavage
Brännvall, Mathias, Kikovska, Ema, Kirsebom, Leif A.
To monitor functionally important metal ions and possible cross talk in RNase P RNA mediated cleavage we studied cleavage of substrates, where the 2′OH at the RNase P cleavage site (at −1) and/or...
Kikovska, Ema, Brännvall, Mathias, Kufel, Joanna, Kirsebom, Leif A.
Like the translational elongation factor EF-Tu, RNase P interacts with a large number of substrates where RNase P with its RNA subunit generates tRNAs with matured 5′ termini by cleaving tRNA...
The naturally trans-acting ribozyme RNase P RNA has leadzyme properties
Kikovska, Ema, Mikkelsen, Nils-Egil, Kirsebom, Leif A.
Divalent metal ions promote hydrolysis of RNA backbones generating 5′OH and 2′;3′P as cleavage products. In these reactions, the neighboring 2′OH act as the nucleophile. RNA catalyzed...
Cross talk between the +73/294 interaction and the cleavage site in RNase P RNA mediated cleavage
Brännvall, Mathias, Kikovska, Ema, Kirsebom, Leif A.
To monitor functionally important metal ions and possible cross talk in RNase P RNA mediated cleavage we studied cleavage of substrates, where the 2′OH at the RNase P cleavage site (at −1) and/or...
Kikovska, Ema, Brännvall, Mathias, Kufel, Joanna, Kirsebom, Leif A.
Like the translational elongation factor EF-Tu, RNase P interacts with a large number of substrates where RNase P with its RNA subunit generates tRNAs with matured 5′ termini by cleaving tRNA...
The naturally trans-acting ribozyme RNase P RNA has leadzyme properties
Kikovska, Ema, Mikkelsen, Nils-Egil, Kirsebom, Leif A.
Divalent metal ions promote hydrolysis of RNA backbones generating 5′OH and 2′;3′P as cleavage products. In these reactions, the neighboring 2′OH act as the nucleophile. RNA catalyzed...
Eukaryotic RNase P RNA mediates cleavage in the absence of protein
Kikovska, Ema, Svärd, Staffan G., Kirsebom, Leif A.
The universally conserved ribonucleoprotein RNase P is involved in the processing of tRNA precursor transcripts. RNase P consists of one RNA and, depending on its origin, a variable number of protein...