Genetic and functional association of FAM5Cwith myocardial infarction (2008)
Connelly, Jessica J, Shah, Svati H, Doss, Jennifer F, Gadson, Shera, Nelson, Sarah, Crosslin, David R, ...
Abstract Background We previously identified a 40 Mb region of linkage on chromosome 1q in our early onset coronary artery disease (CAD) genome-wide linkage scan (GENECARD) with modest evidence for...
Comparison of GIST and LAMP on the GAW15 simulated data (2007)
Lou, Xuemei, Schmidt, Silke, Hauser, Elizabeth R
Abstract After genetic linkage has been identified for a complex disease, the next step is often fine-mapping by association analysis, using single-nucleotide polymorphisms (SNPs) within a linkage...
Schmidt, Mike, Qin, Xuejun, Martin, Eden R, Hauser, Elizabeth R, Schmidt, Silke
Abstract The incorporation of disease-associated covariates into studies aiming to identify susceptibility genes for complex human traits is a challenging problem. Accounting for such covariates in...
Visualizing genotype × phenotype relationships in the GAW15 simulated data (2007)
Qin, Xuejun, Schmidt, Silke, Martin, Eden, Hauser, Elizabeth R
Abstract We have developed a graphical display tool called SIMLAPLOT for visualizing different ways in which continuous covariates may influence the genotype-specific risk for complex human diseases....
Cordell, Heather J, De Andrade, Mariza, Babron, Marie-Claude, Bartlett, Christopher W, Beyene, Joseph, Bickeböller, Heike, ...
No abstract available.
Cordell, Heather J, De Andrade, Mariza, Babron, Marie-Claude, Bartlett, Christopher W, Beyene, Joseph, Bickeb Ller, Heike, ...
GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease (2006)
Jessica J. Connelly, Tianyuan Wang, Julie E. Cox, Carol Haynes, Liyong Wang, Svati H. Shah, ...
The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the...
GATA2 is associated with familial early onset coronary artery disease (2006)
Jessica Jeanne Connelly, Ty Wang, Julie Cox, Carol Haynes, Liyong Wang, Svati H Shah, ...
The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the...
Searching for epistatic interactions in nuclear families using conditional linkage analysis (2005)
Shah, Svati H, Schmidt, Michael A, Mei, Hao, Scott, William K, Hauser, Elizabeth R, Schmidt, Silke
Abstract Background Genomic screens generally employ a single-locus strategy for linkage analysis, but this may have low power in the presence of epistasis. Ordered subsets analysis (OSA) is a method...
Schmidt, Mike, Hauser, Elizabeth R, Martin, Eden R., Schmidt, Silke
We have previously distributed a software package, SIMLA (SIMulation of Linkage and Association), which can be used to generate disease phenotype and marker genotype data in three-generational...
Schmidt, Mike, Hauser, Elizabeth R, Martin, Eden R., Schmidt, Silke
We have previously distributed a software package, SIMLA (SIMulation of Linkage and Association), which can be used to generate disease phenotype and marker genotype data in three-generational...
Schmidt, Mike, Hauser, Elizabeth R, Martin, Eden R., Schmidt, Silke
We have previously distributed a software package, SIMLA (SIMulation of Linkage and Association), which can be used to generate disease phenotype and marker genotype data in three-generational...
Schmidt, Mike, Hauser, Elizabeth R, Martin, Eden R., Schmidt, Silke
We have previously distributed a software package, SIMLA (SIMulation of Linkage and Association), which can be used to generate disease phenotype and marker genotype data in three-generational...
Stenger, Judith E, Xu, Hong, Haynes, Carol, Hauser, Elizabeth R, Pericak-Vance, Margaret, Goldschmidt-Clermont, Pascal J, ...
Abstract Background To facilitate efficient selection and the prioritization of candidate complex disease susceptibility genes for association analysis, increasingly comprehensive annotation tools...
Schmidt, Silke, Scott, William K, Postel, Eric A, Agarwal, Anita, Hauser, Elizabeth R, De La Paz, Monica A, ...
Abstract Background Age-related macular degeneration (AMD) is a complex disorder that is responsible for the majority of central vision loss in older adults living in developed countries. Phenotypic...
Adjusting for covariates on a slippery slope: linkage analysis of change over time (2003)
Rampersaud, Evadnie, Allen, Andrew, Li, Yi-Ju, Shao, Yujun, Bass, Meredyth, Haynes, Carol, ...
Abstract Background We analyzed the Genetic Analysis Workshop 13 (GAW13) simulated data to contrast and compare different methods for the genetic linkage analysis of hypertension and change in blood...
Hauser, Elizabeth R., Boehnke, Michael, Guo, Sun-Wei, Risch, Neil
We describe an extension of Risch's [(1990a,b) Am J Hum Genet 46:222–228, 229–241] method of linkage detection and exclusion for complex genetic traits. The method uses interval mapping to infer...
Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs
Ghosh, Soumitra, Watanabe, Richard M., Hauser, Elizabeth R., Valle, Timo, Magnuson, Victoria L., Erdos, Michael R., ...
We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477 Finnish families. To date, our best...
Schmidt, Silke, Scott, William K, Postel, Eric A, Agarwal, Anita, Hauser, Elizabeth R, De La Paz, Monica A, ...
Stenger, Judith E, Xu, Hong, Haynes, Carol, Hauser, Elizabeth R, Pericak-Vance, Margaret, Goldschmidt-Clermont, Pascal J, ...
Boyles, Abee L., Scott, William K., Martin, Eden R., Schmidt, Silke, Li, Yi-Ju, Ashley-Koch, Allison, ...
Ghosh, Soumitra, Watanabe, Richard M., Valle, Timo T., Hauser, Elizabeth R., Magnuson, Victoria L., Langefeld, Carl D., ...
We performed a genome scan at an average resolution of 8 cM in 719 Finnish sib pairs with type 2 diabetes. Our strongest results are for chromosome 20, where we observe a weighted maximum LOD score...
Watanabe, Richard M., Ghosh, Soumitra, Langefeld, Carl D., Valle, Timo T., Hauser, Elizabeth R., Magnuson, Victoria L., ...
Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes–related quantitative traits in 580...
SNPselector: a web tool for selecting SNPs for genetic association studies
Xu, Hong, Gregory, Simon G., Hauser, Elizabeth R., Stenger, Judith E., Pericak Vance, Margaret A., Vance, Jeffery M., ...
Summary: Single nucleotide polymorphisms (SNPs) are commonly used for association studies to find genes responsible for complex genetic diseases. With the recent advance of SNP technology,...
Early Adult-Onset POAG Linked to 15q11-13 Using Ordered Subset Analysis
Allingham, R. Rand, Wiggs, Janey L., Hauser, Elizabeth R., Larocque-Abramson, Karen R., Santiago-Turla, Cecilia, Broomer, Bob, ...
Schmidt, Mike, Hauser, Elizabeth R., Martin, Eden R., Schmidt, Silke
We have previously distributed a software package, SIMLA (SIMulation of Linkage and Association), which can be used to generate disease phenotype and marker genotype data in three-generational...
GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease
Connelly, Jessica J, Wang, Tianyuan, Cox, Julie E, Haynes, Carol, Wang, Liyong, Shah, Svati H, ...
The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the...
BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis
Chamberlain, Jeffrey S., Boehnke, Michael, Frank, Thomas S., Kiousis, Sam, Xu, Junxhe, Guo, Sun-Wei, ...
Previous studies have demonstrated linkage between early-onset breast cancer and ovarian cancer and genetic markers on chromosome 17q21. These markers define the location of a gene (BRCA1) which...
Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs
Ghosh, Soumitra, Watanabe, Richard M., Hauser, Elizabeth R., Valle, Timo, Magnuson, Victoria L., Erdos, Michael R., ...
We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477 Finnish families. To date, our best...
Schmidt, Silke, Scott, William K, Postel, Eric A, Agarwal, Anita, Hauser, Elizabeth R, De La Paz, Monica A, ...
Stenger, Judith E, Xu, Hong, Haynes, Carol, Hauser, Elizabeth R, Pericak-Vance, Margaret, Goldschmidt-Clermont, Pascal J, ...
Accounting for Linkage in Family-Based Tests of Association with Missing Parental Genotypes
Martin, Eden R., Bass, Meredyth P., Hauser, Elizabeth R., Kaplan, Norman L.
In studies of complex diseases, a common paradigm is to conduct association analysis at markers in regions identified by linkage analysis, to attempt to narrow the region of interest. Family-based...
Ordered-Subsets Linkage Analysis Detects Novel Alzheimer Disease Loci on Chromosomes 2q34 and 15q22
Scott, William K., Hauser, Elizabeth R., Schmechel, Donald E., Welsh-Bohmer, Kathleen A., Small, Gary W., Roses, Allen D., ...
Alzheimer disease (AD) is a complex disorder characterized by a wide range, within and between families, of ages at onset of symptoms. Consideration of age at onset as a covariate in genetic-linkage...
A Genomewide Scan for Early-Onset Coronary Artery Disease in 438 Families: The GENECARD Study
Hauser, Elizabeth R., Crossman, David C., Granger, Christopher B., Haines, Jonathan L., Jones, Christopher J. H., Mooser, Vincent, ...
A family history of coronary artery disease (CAD), especially when the disease occurs at a young age, is a potent risk factor for CAD. DNA collection in families in which two or more siblings are...
Ghosh, Soumitra, Watanabe, Richard M., Valle, Timo T., Hauser, Elizabeth R., Magnuson, Victoria L., Langefeld, Carl D., ...
We performed a genome scan at an average resolution of 8 cM in 719 Finnish sib pairs with type 2 diabetes. Our strongest results are for chromosome 20, where we observe a weighted maximum LOD score...
Watanabe, Richard M., Ghosh, Soumitra, Langefeld, Carl D., Valle, Timo T., Hauser, Elizabeth R., Magnuson, Victoria L., ...
Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes–related quantitative traits in 580...
GATA2 Is Associated with Familial Early-Onset Coronary Artery Disease
Connelly, Jessica J, Wang, Tianyuan, Cox, Julie E, Haynes, Carol, Wang, Liyong, Shah, Svati H, ...
The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the...
BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis
Chamberlain, Jeffrey S., Boehnke, Michael, Frank, Thomas S., Kiousis, Sam, Xu, Junxhe, Guo, Sun-Wei, ...
Previous studies have demonstrated linkage between early-onset breast cancer and ovarian cancer and genetic markers on chromosome 17q21. These markers define the location of a gene (BRCA1) which...
Adjusting for covariates on a slippery slope: linkage analysis of change over time
Rampersaud, Evadnie, Allen, Andrew, Li, Yi-Ju, Shao, Yujun, Bass, Meredyth, Haynes, Carol, ...
Searching for epistatic interactions in nuclear families using conditional linkage analysis
Shah, Svati H, Schmidt, Michael A, Mei, Hao, Scott, William K, Hauser, Elizabeth R, Schmidt, Silke
Wang, Liyong, Hauser, Elizabeth R., Shah, Svati H., Pericak-Vance, Margaret A., Haynes, Carol, Crosslin, David, ...
A susceptibility locus for coronary artery disease (CAD) has been mapped to chromosome 3q13-21 in a linkage study of early-onset CAD. We completed an association-mapping study across the...
Visualizing genotype × phenotype relationships in the GAW15 simulated data
Qin, Xuejun, Schmidt, Silke, Martin, Eden, Hauser, Elizabeth R
We have developed a graphical display tool called SIMLAPLOT for visualizing different ways in which continuous covariates may influence the genotype-specific risk for complex human diseases. The...
Schmidt, Mike, Qin, Xuejun, Martin, Eden R, Hauser, Elizabeth R, Schmidt, Silke
The incorporation of disease-associated covariates into studies aiming to identify susceptibility genes for complex human traits is a challenging problem. Accounting for such covariates in genetic...
Cordell, Heather J, De Andrade, Mariza, Babron, Marie-Claude, Bartlett, Christopher W, Beyene, Joseph, Bickeböller, Heike, ...
Comparison of GIST and LAMP on the GAW15 simulated data
Lou, Xuemei, Schmidt, Silke, Hauser, Elizabeth R
After genetic linkage has been identified for a complex disease, the next step is often fine-mapping by association analysis, using single-nucleotide polymorphisms (SNPs) within a linkage region. If...