Graduation date: 2008
Graduation date: 2008
Sex Differences in the ACTH Response to 24H Metyrapone in Depression (2006)
Young, Elizabeth A., Ribeiro, Saulo C. M.
pre-print
Disordered Adrenocorticotropin Secretion in Women with Major Depression (2006)
Young, Elizabeth A., Veldhuis, Johannes D.
Context: Major depression is accompanied by activation of the hypothalamic pituitary axis and evidence of abnormalities in circadian and ultradian hormone rhythms. In addition, diminished negative...
Walker, J. Michael, Moises, Hylan C., Coy, David H., Young, Elizabeth A., Watson, Stanley J., Akil, Huda
Dynorphin and an opiate-inactive fragment des-Tyr-dynorphin produced similar effects on EEG, motor function and hippocampal unit firing. Naloxone had no effect on the actions of dynorphin in these...
Young, Elizabeth A., Ribeiro, Saulo C. M., Ye, Wen
pre-print
The Biological Underpinnings of Depression. (2006)
Korszun, Ania, Altemus, Margaret, Young, Elizabeth A.
chapter
Young, Elizabeth A., Abelson, James L., Cameron, Oliver G.
Background: Numerous interactions between the brainstem locus coeruleus system and the HPA axis have been shown in experimental animals. This relationship is less well characterized in humans and...
Modeling cortisol rhythms in a population-based study (2005)
Ranjit, Nalini, Young, Elizabeth A., Raghunathan, Trivellore E., Kaplan, George A.
Peer Reviewed
Strategies and Methods for Research on Sex Differences in Brain and Behavior (2005)
Becker, Jill B., Arnold, Arthur P., Berkley, Karen J., Blaustein, Jeffrey D., Eckel, Lisa, Hampson, Elizabeth, ...
Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although...
Kasa-Vubu, Josephine Z., Dimaraki, Eleni V., Young, Elizabeth A.
Objective Major depression is associated to altered hypothalamic pituitary function. Stress is linked to elevated cortisol as well as menstrual cycle disturbance; however, there is no known...
Young, Elizabeth A., Abelson, James L., Cameron, Oliver G.
Background: Major depressive disorder (MDD) is often complicated by anxiety symptoms, and anxiety disorders occur in approximately 30% of mood cases. This study examined the influence of anxiety...
Cameron, Oliver G., Abelson, James L., Young, Elizabeth A.
Background: Although comorbidity of anxiety with depression is common, investigations of physiologic abnormalities related specifically to comorbidity are rare. This study examined relationships of...
Saliva Cortisol in Posttraumatic Stress Disorder: (2004)
Young, Elizabeth A, Breslau, Naomi
Background: Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, so it was expected that posttraumatic stress disorder (PTSD) would be associated with activation of this axis; however,...
Cortisol and Catecholamines in Posttraumatic Stress Disorder (2004)
Young, Elizabeth A, Breslau, Naomi
Background: Prior research has connected posttraumatic stress disorder (PTSD) to increased levels of catecholamines. However, studies of cortisol levels have produced mixed results. Objective: To...
Puberty, Ovarian Steroids and Stress (2004)
Young, Elizabeth A., Altemus, Margaret
Puberty is accompanied by a number of changes and among them an increased risk for development of major depression. The most common etiology of major depression are stressful life events, being...
Cortisol pulsatility and its role in stress regulation and health (2004)
Young, Elizabeth A., Abelson, James L., Lightman, Stafford L.
commentary
Pulsatile luteinizing hormone disruption in depression (2004)
Grambsch, Patricia, Young, Elizabeth A., Meller, William H.
Two independent groups recently published data comparing pulsatile luteinizing hormone (LH) release between depressed and control women. Despite similar populations and LH sampling frequency, they...
Salivary Cortisol and Posttraumatic Stress Disorder in a Low-Income Community Sample of Women (2003)
Young, Elizabeth A., Tolman, Richard, Witkowski, Kristine, Kaplan, George
http://deepblue.lib.umich.edu/bitstream/2027.42/51381/1/Young EA, Salivary Cortisol and Posttraumatic Stress Disorder, 2004.pdf
The hypothalamic pituitary gonadal axis in mood disorders (2002)
Young, Elizabeth A., Korszun, Ania
review article
Sex differences in Neuroendocrine and Neurotransmitter Systems (2002)
Young, Elizabeth A., Korszun, Ania, Altemus, Margaret
chapter
Marital functioning and satisfaction : an empirical test of a clinically successful model / (2002)
Typescript.
Twenty-Four-Hour ACTH and Cortisol Pulsatility in Depressed Women (2001)
Young, Elizabeth A., Carlson, Nichole E., Brown, Morton B.
Increased plasma cortisol in patients with major depression is a well documented finding, although it is present in only 25–30% of subjects with major depression. However, ACTH and cortisol are...
Alteration in the Hypothalamic-Pituitary-Ovarian in Depressed Women (2000)
Young, Elizabeth A., Midgley, A. Rees, Carlson, Nichole E., Brown, Morton B.
final version
Childhood adversity and vulnerability to mood and anxiety disorders (1997)
Young, Elizabeth A., Abelson, James L., Curtis, George C., Nesse, Randolph M.
Based upon epidemiological surveys, adverse childhood events are proposed to be risk factors for adult depressive and anxiety disorders. However, the extent to which these events are seen in clinical...
Akil, Huda, Haskett, R. F., Young, Elizabeth A., Grunhaus, L., Kotun, Joan, Weinberg, V., ...
We have previously shown that a number of depressed patients demonstrated a failure to suppress corticotrophic secretion, as measured by [beta]-Endorphin/[beta]-Lipotropin ([beta]-End/[beta]-LPH...
Herman, James P., Cullinan, William E., Young, Elizabeth A., Akil, Huda, Watson, Stanley J.
The hippocampus appears to be involved in tonic regulation of the hypothalamo-pituitary-adrenocortical axis via interactions with corticotropin-releasing hormone (CRH) and arginine vasopressin...
Spencer, Robert L., Young, Elizabeth A., Choo, Phillip H., McEwen, Bruce S.
Adrenal steroid (AS) receptors differ from other steroid receptors in the inability of the activated form of the cytosolic receptor to exchange ligand in an in vitro binding assay. We extended this...
Young, Elizabeth A., Spencer, Robert L., McEwen, Bruce S.
Seizures, including electrically induced seizures (ECS), activate the hypothalamo-pituitary-adrenal (HPA) axis in rats. The present studies were undertaken to characterize the effects of repeated ECS...
Herman, James P., Schafer, Martin K. -H., Sladek, Celia D., Day, Robert, Young, Elizabeth A., Akil, Huda, ...
The effects of repeated electroconvulsive seizures (ECS) on expression of mRNAs coding for corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) in neuroendocrine neurons of the...
Degradation of [3H][beta]-endorphin in rat plasma is increased with chronic stress (1989)
Young, Elizabeth A., Houghten, Richard A., Akil, Huda
With a number of acute stressors [beta]-endorphin is released into plasma. It is unclear if [beta]-endorphin is converted into any other biologically active products, nor it is clear if the rate or...
Young, Elizabeth A., Akil, Huda
We have previously demonstrated a number of changes in the anterior lobe proopiomelanocortin (POMC) system in chronically stressed rats. The purpose of the present experiments was to investigate...
Robinson, Terry E., Becker, Jill B., Young, Elizabeth A., Akil, Huda, Castaneda, Edward
The repeated intermittent administration of amphetamine (AMP) produces an enduring enhancement in the response of dopamine (DA) systems in the brain to a subsequent "challenge" with amphetamine....
[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13 (1987)
Michael Walker, J., Coy, David H., Young, Elizabeth A., Baldrighi, Giulio, Siegel, Stephen F., Bowen, Wayne D., ...
Intracerebroventricular administration of the dynorphin analog, [D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonized by...
The degradation of dynorphin A in brain tissue in vivo and in vitro (1987)
Young, Elizabeth A., Walker, J. Michael, Houghten, Richard A., Akil, Huda
The demonstration of analgesia following in vivo administration of dynorphin A (Dyn A) has been difficult. In contrast, a number of electrophysiological and behavioral effects reported with in vivo...
Young, Elizabeth A., Walker, J. Michael, Lewis, Michael E., Houghten, Richard A., Woods, James H., Akil, Huda
We have previously demonstrated that [3H]dynorphin A selectively labels [kappa] opioid receptors in guinea-pig whole brain. In these current studies, using protection from inactivation by...
Young, Elizabeth A., Lewis, James W., Akil, Huda
Although a number of investigators have shown that release of ACTH is accompanied by the release of Beta-endorphin ([beta]-End) and Beta-lipotropin ([beta]-LPH), the proportion of the latter two...
Changes in releasability of ACTH and Beta-endorphin with chronic stress (1985)
Young, Elizabeth A., Akil, Huda
The activation of the hypothalamic pituitary adrenal axis by stress is well-known. Using inescapable intermittent footshock as a stressor in rats, we have previously demonstrated a rise in...
Lewis, Michael E., Young, Elizabeth A., Houghten, Richard A., Akil, Huda, Watson, Stanley J.
Peer Reviewed
[3H]Dynorphin a binds selectively to guinea pig brain (1983)
Young, Elizabeth A., Michael Walker, J., Houghten, Richard A., Akil, Huda
Peer Reviewed
[3H] dynorphin binding to guinea pig and rat brain (1983)
Young, Elizabeth A., Walker, J. Michael, Houghten, Richard A., Akil, Huda
[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types...
Increase in delta, but not mu, receptors in MSG-treated rats (1982)
Young, Elizabeth A., Olney, John W., Akil, Huda
Neonatal treatment of rats with Monosodium Glutamate (MSG) has been demonstrated to destroy cell bodies of neurons in the arcuate nucleus including the brain beta-endorphin (B-END) system. The...
The Health of Poor Women Under Welfare Reform
Kaplan, George A., Siefert, Kristine, Ranjit, Nalini, Raghunathan, Trivellore E., Young, Elizabeth A., Tran, Diem, ...
Objectives. We compared the health of single mothers affected by welfare reform with the health of a nationally representative sample of women to document the prevalence of poor health as single...
HPA axis activity in patients with panic disorder: review and synthesis of four studies
Abelson, James L., Khan, Samir, Liberzon, Israel, Young, Elizabeth A.
Dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis may play a role in panic disorder. HPA studies in patients with panic disorder, however, have produced inconsistent results. Seeking...