Shin-Hong Shiao, Daniel Zachary, Jules A. Hoffmann, Elena A. Levashina
The midgut epithelium of the mosquito malaria vector Anopheles is a hostile environment for Plasmodium, with most parasites succumbing to host defenses. This study addresses morphological and...
Budd, Aidan, Blandin, Stephanie, Levashina, Elena A, Gibson, Toby J
Abstract Background Invasive bacteria are known to have captured and adapted eukaryotic host genes. They also readily acquire colonizing genes from other bacteria by horizontal gene transfer. Closely...
Lagueux, Marie, Perrodou, Emmanuel, Levashina, Elena A., Capovilla, Maria, Hoffmann, Jules A.
We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/α2-macroglobulin superfamily. The genes are...
Goto, Akira, Blandin, Stéphanie, Royet, Julien, Reichhart, Jean-Marc, Levashina, Elena A.
Double-stranded RNA (dsRNA) gene interference is an efficient method to silence gene expression in a sequence-specific manner. Here we show that the direct injection of dsRNA can be used in adult...
Budd, Aidan, Blandin, Stephanie, Levashina, Elena A, Gibson, Toby J
Homologs of metazoan α2-macroglobulins have been found in bacteria. The distribution of these genes in diverse bacterial clades suggests they have been acquired by multiple horizontal transfers.
Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene
Blandin, Stéphanie, Moita, Luis F., Köcher, Thomas, Wilm, Matthias, Kafatos, Fotis C., Levashina, Elena A.
Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector–parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA)...
Lagueux, Marie, Perrodou, Emmanuel, Levashina, Elena A., Capovilla, Maria, Hoffmann, Jules A.
We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/α2-macroglobulin superfamily. The genes are...
Goto, Akira, Blandin, Stéphanie, Royet, Julien, Reichhart, Jean-Marc, Levashina, Elena A.
Double-stranded RNA (dsRNA) gene interference is an efficient method to silence gene expression in a sequence-specific manner. Here we show that the direct injection of dsRNA can be used in adult...
Budd, Aidan, Blandin, Stephanie, Levashina, Elena A, Gibson, Toby J
Homologs of metazoan α2-macroglobulins have been found in bacteria. The distribution of these genes in diverse bacterial clades suggests they have been acquired by multiple horizontal transfers.
Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene
Blandin, Stéphanie, Moita, Luis F., Köcher, Thomas, Wilm, Matthias, Kafatos, Fotis C., Levashina, Elena A.
Anopheles gambiae, the major vector of human malaria parasite, is an important insect model to study vector–parasite interactions. Here, we developed a simple in vivo double-stranded RNA (dsRNA)...
Shiao, Shin-Hong, Whitten, Miranda M. A, Zachary, Daniel, Hoffmann, Jules A, Levashina, Elena A
The midgut epithelium of the mosquito malaria vector Anopheles is a hostile environment for Plasmodium, with most parasites succumbing to host defenses. This study addresses morphological and...
Structural basis for conserved complement factor-like function in the antimalarial protein TEP1
Baxter, Richard H. G., Chang, Chung-I, Chelliah, Yogarany, Blandin, Stéphanie, Levashina, Elena A., Deisenhofer, Johann
Thioester-containing proteins (TEPs) are a major component of the innate immune response of insects to invasion by bacteria and protozoa. TEPs form a distinct clade of a superfamily that includes the...