Eldo E. Frezza

The pituitary tumor transforming gene 1 (PTTG-1): An immunological target for multiple myeloma (2008)

Chiriva-Internati, Maurizio, Ferrari, Raffaele, Prabhakar, Madhavi, Yu, Yuefei, Baggoni, Luigi, Moreno, Jorge, ...

Abstract Background Multiple Myeloma is a cancer of B plasma cells, which produce non-specific antibodies and proliferate uncontrolled. Due to the potential relapse and non-specificity of current...

Combined Hepatocellular Cholangiocarcinomas; Analysis of a Large Database (2008)

Mitchell S. Wachtel, Yan Zhang, Tom Xu, Maurizio Chiriva-Internati, Eldo E Frezza

Aim: Combined hepatocellular cholangiocarcinoma (combined tumor) has been described as either a variant of hepatoma or a variant of cholangiocarcinoma. Prior studies evaluated fewer than 50 patients...

Pancreas Cancer Survival in the Gemcitabine Era (2008)

Mitchell S. Wachtel, K. Tom Xu, Yan Zhang, Maurizio Chiriva-Internati, Eldo E. Frezza

After multiple positive studies, gemcitabine, approved for the treatment of pancreas cancer by the FDA in 1977, became standard of care. Whether this therapeutic advance has translated into longer...

Usefulness of cancer-testis antigens as biomarkers for the diagnosis and treatment of hepatocellular carcinoma (2007)

Grizzi, Fabio, Franceschini, Barbara, Hamrick, Cody, Frezza, Eldo E, Cobos, Everardo, Chiriva-Internati, Maurizio

Abstract Despite advances in our cellular and molecular knowledge, hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. It is now known to be highly...

Cancer initiation and progression: an unsimplifiable complexity (2006)

Grizzi, Fabio, Di Ieva, Antonio, Russo, Carlo, Frezza, Eldo E, Cobos, Everardo, Muzzio, Pier, ...

Abstract Background Cancer remains one of the most complex diseases affecting humans and, despite the impressive advances that have been made in molecular and cell biology, how cancer cells progress...

Different regression equations relate age to the incidence of Lauren types 1 and 2 stomach cancer in the SEER database: these equations are unaffected by sex or race (2006)

Wachtel, Mitchell S, Zhang, Yan, Chiriva-Internati, Maurizio, Frezza, Eldo E

Abstract Background Although impacts upon gastric cancer incidence of race, age, sex, and Lauren type have been individually explored, neither their importance when evaluated together nor the...

Sperm protein 17 is expressed in human nervous system tumours (2006)

Grizzi, Fabio, Gaetani, Paolo, Franceschini, Barbara, Di Ieva, Antonio, Colombo, Piergiuseppe, Ceva-Grimaldi, Giorgia, ...

Abstract Background Human sperm protein 17 (Sp17) is a highly conserved protein that was originally isolated from a rabbit epididymal sperm membrane and testis membrane pellet. It has recently been...

Quantitative evaluation and modeling of two-dimensional neovascular network complexity: the surface fractal dimension (2005)

Grizzi, Fabio, Russo, Carlo, Colombo, Piergiuseppe, Franceschini, Barbara, Frezza, Eldo E, Cobos, Everardo, ...

Abstract Background Modeling the complex development and growth of tumor angiogenesis using mathematics and biological data is a burgeoning area of cancer research. Architectural complexity is the...

The Six Stages of the Healthcare Economy-Is Socialized Medicine at the Door? A Historical Review (2005)

Eldo E. Frezza

The healthcare industry, nonexistent a century ago, is now a huge fraction of the U.S.economy and an intricate business with a multitude of legislative problems. This review article willsummarize the...

Survival in the Current Healthcare Environment How Close Are We to Socialized Medicine? (2005)

Eldo E. Frezza

In the 1980’s, some hospitals established internal agencies to regulate cash flow and capitalexpense. State agencies promoted the evolution of healthcare facilities into more...

Usefulness of cancer-testis antigens as biomarkers for the diagnosis and treatment of hepatocellular carcinoma

Grizzi, Fabio, Franceschini, Barbara, Hamrick, Cody, Frezza, Eldo E, Cobos, Everardo, Chiriva-Internati, Maurizio

Despite advances in our cellular and molecular knowledge, hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. It is now known to be highly...