PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations (2007)
Peristera Paschou, Elad Ziv, Esteban G. Burchard, Shweta Choudhry, William Rodriguez-Cintron, Michael W. Mahoney, ...
Existing methods to ascertain small sets of markers for the identification of human population structure require prior knowledge of individual ancestry. Based on Principal Components Analysis (PCA),...
Categorization of humans in biomedical research: genes, race and disease (2002)
Risch, Neil, Burchard, Esteban, Ziv, Elad, Tang, Hua
Abstract A debate has arisen regarding the validity of racial/ethnic categories for biomedical and genetic research. Some claim 'no biological basis for race' while others advocate a 'race-neutral'...
Categorization of humans in biomedical research: genes, race and disease (2002)
Risch, Neil, Burchard, Esteban, Ziv, Elad, Tang, Hua
A debate has arisen regarding the validity of racial/ethnic categories for biomedical and genetic research. Some claim ‘no biological basis for race’ while others advocate a ‘race-neutral’...
Categorization of humans in biomedical research: genes, race and disease
Risch, Neil, Burchard, Esteban, Ziv, Elad, Tang, Hua
A debate has arisen regarding the validity of racial/ethnic categories for biomedical and genetic research. An epidemiologic perspective on the issue of human categorization in biomedical and genetic...
Categorization of humans in biomedical research: genes, race and disease
Risch, Neil, Burchard, Esteban, Ziv, Elad, Tang, Hua
A debate has arisen regarding the validity of racial/ethnic categories for biomedical and genetic research. An epidemiologic perspective on the issue of human categorization in biomedical and genetic...
Reiner, Alexander P., Ziv, Elad, Lind, Denise L., Nievergelt, Caroline M., Schork, Nicholas J., Cummings, Steven R., ...
U.S. populations are genetically admixed, but surprisingly little empirical data exists documenting the impact of such heterogeneity on type I and type II error in genetic-association studies of...
PCA-Correlated SNPs for Structure Identification in Worldwide Human Populations
Paschou, Peristera, Ziv, Elad, Burchard, Esteban G, Choudhry, Shweta, Rodriguez-Cintron, William, Mahoney, Michael W, ...
Existing methods to ascertain small sets of markers for the identification of human population structure require prior knowledge of individual ancestry. Based on Principal Components Analysis (PCA),...
Admixture Mapping of an Allele Affecting Interleukin 6 Soluble Receptor and Interleukin 6 Levels
Reich, David, Patterson, Nick, Ramesh, Vijaya, De Jager, Philip L., McDonald, Gavin J., Tandon, Arti, ...
Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms...
González Burchard, Esteban, Borrell, Luisa N., Choudhry, Shweta, Naqvi, Mariam, Tsai, Hui-Ju, Rodriguez-Santana, Jose R., ...
Latinos are the largest minority population in the United States. Although usually classified as a single ethnic group by researchers, Latinos are heterogeneous from cultural, socioeconomic, and...
Nalls, Michael A., Wilson, James G., Patterson, Nick J., Tandon, Arti, Zmuda, Joseph M., Huntsman, Scott, ...
White blood cell count (WBC) is an important clinical marker that varies among different ethnic groups. African Americans are known to have a lower WBC than European Americans. We surveyed the entire...
Tracing Sub-Structure in the European American Population with PCA-Informative Markers
Paschou, Peristera, Drineas, Petros, Lewis, Jamey, Nievergelt, Caroline M., Nickerson, Deborah A., Smith, Joshua D., ...
Genetic structure in the European American population reflects waves of migration and recent gene flow among different populations. This complex structure can introduce bias in genetic association...