Ekdahl, Christine T., Mohapel, Paul, Weber, Ekkehard, Bahr, Ben, Blomgren, Klas, Lindvall, Olle
A large proportion of cells that proliferate in the adult dentate gyrus under normal conditions or in response to brain insults exhibit only short-term survival. Here, we sought to determine which...
Thesis (doctoral)--Universität Stuttgart, 1969.
Bania, Jacek, Gatti, Evelina, Lelouard, Hugues, David, Alexandre, Cappello, Fanny, Weber, Ekkehard, ...
MHC class II-restricted antigen presentation plays a central role in the immune response against exogenous antigens. The association of invariant (Ii) chain with MHC class II dimers is required for...
Tolosa, Eva, Li, Weijie, Yasuda, Yoshiyuki, Wienhold, Wolfgang, Denzin, Lisa K., Lautwein, Alfred, ...
Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have...
Bania, Jacek, Gatti, Evelina, Lelouard, Hugues, David, Alexandre, Cappello, Fanny, Weber, Ekkehard, ...
MHC class II-restricted antigen presentation plays a central role in the immune response against exogenous antigens. The association of invariant (Ii) chain with MHC class II dimers is required for...
Tolosa, Eva, Li, Weijie, Yasuda, Yoshiyuki, Wienhold, Wolfgang, Denzin, Lisa K., Lautwein, Alfred, ...
Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have...
Relaxin Enhances the Oncogenic Potential of Human Thyroid Carcinoma Cells
Hombach-Klonisch, Sabine, Bialek, Joanna, Trojanowicz, Bogusz, Weber, Ekkehard, Holzhausen, Hans-Jürgen, Silvertown, Josh D., ...
The role of members of the insulin-like superfamily in human thyroid carcinoma is primarily unknown. Here we demonstrate the presence of RLN2 relaxin and relaxin receptor LGR7 in human papillary,...
Di Piazza, Matteo, Mader, Carmen, Geletneky, Karsten, Herrero Y Calle, Marta, Weber, Ekkehard, Schlehofer, Jörg, ...
Gliomas are often resistant to the induction of apoptotic cell death as a result of the development of survival mechanisms during astrocyte malignant transformation. In particular, the overexpression...
Abdul-Hussien, Hazem, Soekhoe, Ratna G.V., Weber, Ekkehard, Von Der Thüsen, Jan H., Kleemann, Robert, Mulder, Adri, ...
Growth and rupture of abdominal aortic aneurysms (AAAs) result from increased collagen turnover. Collagen turnover critically depends on specific collagenases that cleave the triple helical region of...
Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, ...
Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by...
Invariant Chain Controls the Activity of Extracellular Cathepsin L
Fiebiger, Edda, Maehr, René, Villadangos, José, Weber, Ekkehard, Erickson, Ann, Bikoff, Elizabeth, ...
Secretion of proteases is critical for degradation of the extracellular matrix during an inflammatory response. Cathepsin (Cat) S and L are the major elastinolytic cysteine proteases in mouse...
Fiebiger, Edda, Meraner, Paul, Weber, Ekkehard, Fang, I-Fei, Stingl, Georg, Ploegh, Hidde, ...
Endo/lysosomal proteases control two key events in antigen (Ag) presentation: the degradation of protein Ag and the generation of peptide-receptive major histocompatibility complex (MHC) class II...