Husain, S. Mazher, Usherwood, Edward J., Dyson, Heather, Coleclough, Christopher, Coppola, Michael A., Woodland, David L., ...
Murine gammaherpesvirus 68 (MHV-68) infection of mice is a potential model with which to address fundamental aspects of the pathobiology and host control of gammaherpesvirus latency. Control of...
Functionally Heterogeneous CD8+ T-Cell Memory Is Induced by Sendai Virus Infection of Mice
Usherwood, Edward J., Hogan, Robert J., Crowther, Graham, Surman, Sherri L., Hogg, Twala L., Altman, John D., ...
It has recently been established that memory CD8+ T cells induced by viral infection are maintained at unexpectedly high frequencies in the spleen. While it has been established that these memory...
Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
Wu, Ting-Ting, Usherwood, Edward J., Stewart, James P., Nash, Anthony A., Sun, Ren
Herpesviruses are characterized as having two distinct life cycle phases: lytic replication and latency. The mechanisms of latency establishment and maintenance, as well as the switch from latency to...
Liu, Luzheng, Usherwood, Edward J., Blackman, Marcia A., Woodland, David L.
Diseases caused by gammaherpesviruses such as Epstein-Barr virus are a major health concern, and there is significant interest in developing vaccines against this class of viral infections. However,...
Regression of a Murine Gammaherpesvirus 68-Positive B-Cell Lymphoma Mediated by CD4 T Lymphocytes
Robertson, Kevin A., Usherwood, Edward J., Nash, Anthony A.
Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T...
Latent Antigen Vaccination in a Model Gammaherpesvirus Infection
Usherwood, Edward J., Ward, Kimberley A., Blackman, Marcia A., Stewart, James P., Woodland, David L.
Vaccines that can reduce the load of latent gammaherpesvirus infections are eagerly sought. One attractive strategy is vaccination against latency-associated proteins, which may increase the...
Macrae, Alastair I., Usherwood, Edward J., Husain, S. Mazher, Flaño, Emilio, Kim, In-Jeong, Woodland, David L., ...
This work describes analyses of the function of the murid herpesvirus 4 strain 68 (MHV-68) M2 gene. A frameshift mutation was made in the M2 open reading frame that caused premature termination of...
Obar, Joshua J., Donovan, Douglas C., Crist, Sarah G., Silvia, Ondine, Stewart, James P., Usherwood, Edward J.
DNA vaccination with the M3 gene, encoding an immune evasion molecule expressed during both the acute lytic and persistent phases of murid gammaherpesvirus 68 infection, yielded a significantly lower...
Husain, S. Mazher, Usherwood, Edward J., Dyson, Heather, Coleclough, Christopher, Coppola, Michael A., Woodland, David L., ...
Murine gammaherpesvirus 68 (MHV-68) infection of mice is a potential model with which to address fundamental aspects of the pathobiology and host control of gammaherpesvirus latency. Control of...
Functionally Heterogeneous CD8+ T-Cell Memory Is Induced by Sendai Virus Infection of Mice
Usherwood, Edward J., Hogan, Robert J., Crowther, Graham, Surman, Sherri L., Hogg, Twala L., Altman, John D., ...
It has recently been established that memory CD8+ T cells induced by viral infection are maintained at unexpectedly high frequencies in the spleen. While it has been established that these memory...
Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from Latency
Wu, Ting-Ting, Usherwood, Edward J., Stewart, James P., Nash, Anthony A., Sun, Ren
Herpesviruses are characterized as having two distinct life cycle phases: lytic replication and latency. The mechanisms of latency establishment and maintenance, as well as the switch from latency to...
Liu, Luzheng, Usherwood, Edward J., Blackman, Marcia A., Woodland, David L.
Diseases caused by gammaherpesviruses such as Epstein-Barr virus are a major health concern, and there is significant interest in developing vaccines against this class of viral infections. However,...
Regression of a Murine Gammaherpesvirus 68-Positive B-Cell Lymphoma Mediated by CD4 T Lymphocytes
Robertson, Kevin A., Usherwood, Edward J., Nash, Anthony A.
Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T...
Latent Antigen Vaccination in a Model Gammaherpesvirus Infection
Usherwood, Edward J., Ward, Kimberley A., Blackman, Marcia A., Stewart, James P., Woodland, David L.
Vaccines that can reduce the load of latent gammaherpesvirus infections are eagerly sought. One attractive strategy is vaccination against latency-associated proteins, which may increase the...
Macrae, Alastair I., Usherwood, Edward J., Husain, S. Mazher, Flaño, Emilio, Kim, In-Jeong, Woodland, David L., ...
This work describes analyses of the function of the murid herpesvirus 4 strain 68 (MHV-68) M2 gene. A frameshift mutation was made in the M2 open reading frame that caused premature termination of...
Obar, Joshua J., Donovan, Douglas C., Crist, Sarah G., Silvia, Ondine, Stewart, James P., Usherwood, Edward J.
DNA vaccination with the M3 gene, encoding an immune evasion molecule expressed during both the acute lytic and persistent phases of murid gammaherpesvirus 68 infection, yielded a significantly lower...
Obar, Joshua J., Fuse, Shinichiro, Leung, Erica K., Bellfy, Sarah C., Usherwood, Edward J.
In herpesvirus infections, the virus persists for life but is contained through T-cell-mediated immune surveillance. How this immune surveillance operates is poorly understood. Recent studies of...
Fuse, Shinichiro, Obar, Joshua J., Bellfy, Sarah, Leung, Erica K., Zhang, Weijun, Usherwood, Edward J.
The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells serve as an important costimulatory signal in the activation of T cells. Although the simplistic two-signal...
Control of Gammaherpesvirus Latency by Latent Antigen-Specific Cd8+ T Cells
Usherwood, Edward J., Roy, Douglas J., Ward, Kim, Surman, Sherri L., Dutia, Bernadette M., Blackman, Marcia A., ...
The contribution of the latent antigen-specific CD8+ T cell response to the control of gammaherpesvirus latency is currently obscure. Some latent antigens induce potent T cell responses, but little...
Hogan, Robert J., Zhong, Weimin, Usherwood, Edward J., Cookenham, Tres, Roberts, Alan D., Woodland, David L.
Although CD4+ T cells have been shown to mediate protective cellular immunity against respiratory virus infections, the underlying mechanisms are poorly understood. For example, although...
Lung Epithelial Cells Are a Major Site of Murine Gammaherpesvirus Persistence
Stewart, James P., Usherwood, Edward J., Ross, Alan, Dyson, Heather, Nash, Tony
It is currently believed that latently infected, resting B lymphocytes are central to gammaherpesvirus persistence, whereas mucosal epithelial cells are considered nonessential. We have readdressed...