Edda Fiebiger

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

Fiebiger, Edda, Story, Craig, Ploegh, Hidde L., Tortorella, Domenico

The human cytomegalovirus gene products US2 and US11 induce proteasomal degradation of MHC class I heavy chains. We have generated an enhanced green fluorescent protein–class I heavy chain...

Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin

Fiebiger, Edda, Hirsch, Christian, Vyas, Jatin M., Gordon, Eva, Ploegh, Hidde L., Tortorella, Domenico

The mammalian endoplasmic reticulum (ER)-to-cytosol degradation pathway for disposal of misfolded proteins is an attractive target for therapeutic intervention in diseases that are characterized by...

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

Fiebiger, Edda, Story, Craig, Ploegh, Hidde L., Tortorella, Domenico

The human cytomegalovirus gene products US2 and US11 induce proteasomal degradation of MHC class I heavy chains. We have generated an enhanced green fluorescent protein–class I heavy chain...

Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin

Fiebiger, Edda, Hirsch, Christian, Vyas, Jatin M., Gordon, Eva, Ploegh, Hidde L., Tortorella, Domenico

The mammalian endoplasmic reticulum (ER)-to-cytosol degradation pathway for disposal of misfolded proteins is an attractive target for therapeutic intervention in diseases that are characterized by...

Screen for ISG15-crossreactive Deubiquitinases

Catic, André, Fiebiger, Edda, Korbel, Gregory A., Blom, Daniël, Galardy, Paul J., Ploegh, Hidde L.

Cotranslational endoplasmic reticulum assembly of FcɛRI controls the formation of functional IgE-binding receptors

Fiebiger, Edda, Tortorella, Domenico, Jouvin, Marie-Helene, Kinet, Jean-Pierre, Ploegh, Hidde L.

The human high affinity receptor for IgE (FcɛRI) is a cell surface structure critical for the pathology of allergic reactions. Human FcɛRI is expressed as a tetramer (αβγ2) on basophils or mast...

Invariant Chain Controls the Activity of Extracellular Cathepsin L

Fiebiger, Edda, Maehr, René, Villadangos, José, Weber, Ekkehard, Erickson, Ann, Bikoff, Elizabeth, ...

Secretion of proteases is critical for degradation of the extracellular matrix during an inflammatory response. Cathepsin (Cat) S and L are the major elastinolytic cysteine proteases in mouse...

Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation

Lennon-Duménil, Ana-Maria, Bakker, Arnold H., Maehr, René, Fiebiger, Edda, Overkleeft, Herman S., Rosemblatt, Mario, ...

Here, we describe a new approach designed to monitor the proteolytic activity of maturing phagosomes in live antigen-presenting cells. We find that an ingested particle sequentially encounters...

Cytokines Regulate Proteolysis in Major Histocompatibility Complex Class II–Dependent Antigen Presentation by Dendritic Cells

Fiebiger, Edda, Meraner, Paul, Weber, Ekkehard, Fang, I-Fei, Stingl, Georg, Ploegh, Hidde, ...

Endo/lysosomal proteases control two key events in antigen (Ag) presentation: the degradation of protein Ag and the generation of peptide-receptive major histocompatibility complex (MHC) class II...