Cell-based high-content screening of small-molecule libraries (2007)
Korn, Kerstin, Krausz, Eberhard
Advanced microscopy and the corresponding image analysis have been developed in recent years into a powerful tool for studying molecular and morphological events in cells and tissues. Cell-based...
High-content siRNA screening (2007)
Very recent developments in instrumentation and image analysis have made microscopy applicable to high-throughput screening (HTS). For 'High-Content Screening' modern automated microscopy systems...
RNAi Libraries for Functional Genomics (2006)
Heninger, Anne-Kristin, Kozak, Karol, Kittler, Ralf, Wagner, Jan, Lohmann, Annett, Poser, Ina, ...
Activation of p53 in cervical carcinoma cells by small molecules
Hietanen, Sakari, Lain, Sonia, Krausz, Eberhard, Blattner, Christine, Lane, David P.
In over 90% of cervical cancers and cancer-derived cell lines, the p53 tumor suppressor pathway is disrupted by human papillomavirus (HPV). The HPV E6 protein promotes the degradation of p53 and thus...
Antagonistic action of Six3 and Prox1 at the γ-crystallin promoter
Lengler, Johannes, Krausz, Eberhard, Tomarev, Stanislav, Prescott, Alan, Quinlan, Roy A., Graw, Jochen
γ-Crystallin genes are specifically expressed in the eye lens. Their promoters constitute excellent models to analyse tissue-specific gene expression. We investigated murine Cryge/f promoters of...
Activation of p53 in cervical carcinoma cells by small molecules
Hietanen, Sakari, Lain, Sonia, Krausz, Eberhard, Blattner, Christine, Lane, David P.
In over 90% of cervical cancers and cancer-derived cell lines, the p53 tumor suppressor pathway is disrupted by human papillomavirus (HPV). The HPV E6 protein promotes the degradation of p53 and thus...
Antagonistic action of Six3 and Prox1 at the γ-crystallin promoter
Lengler, Johannes, Krausz, Eberhard, Tomarev, Stanislav, Prescott, Alan, Quinlan, Roy A., Graw, Jochen
γ-Crystallin genes are specifically expressed in the eye lens. Their promoters constitute excellent models to analyse tissue-specific gene expression. We investigated murine Cryge/f promoters of...