Dragos Olteanu

Extracellular zinc and ATP-gated P2X receptor calcium entry channels: New zinc receptors as physiological sensors and therapeutic targets

Schwiebert, Erik M., Liang, Lihua, Cheng, Nai-Lin, Williams, Clintoria Richards, Olteanu, Dragos, Welty, Elisabeth A., ...

In this review, we focus on two attributes of P2X receptor channel function, one essential and one novel. First, we propose that P2X receptors are extracellular sensors as well as receptors and ion...

Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals

Hovater, Michael B., Olteanu, Dragos, Hanson, Elizabeth L., Cheng, Nai-Lin, Siroky, Brian, Fintha, Attila, ...

Renal epithelial cells release ATP constitutively under basal conditions and release higher quantities of purine nucleotide in response to stimuli. ATP filtered at the glomerulus, secreted by...

Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts

Hovater, Michael B., Olteanu, Dragos, Welty, Elisabeth A., Schwiebert, Erik M.

The nephron is the functional unit of the kidney. Blood and plasma are continually filtered within the glomeruli that begin each nephron. Adenosine 5′ triphosphate (ATP) and its metabolites are...