Donna M. Driscoll

Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNA

Mehta, Anuradha, Kinter, Michael T., Sherman, Nicholas E., Driscoll, Donna M.

The C-to-U editing of apolipoprotein B (apo-B) mRNA is catalyzed by a multiprotein complex that recognizes an 11-nucleotide mooring sequence downstream of the editing site. The catalytic subunit of...

Insight into Mammalian Selenocysteine Insertion: Domain Structure and Ribosome Binding Properties of Sec Insertion Sequence Binding Protein 2

Copeland, Paul R., Stepanik, Vincent A., Driscoll, Donna M.

The cotranslational incorporation of the unusual amino acid selenocysteine (Sec) into both prokaryotic and eukaryotic proteins requires the recoding of a UGA stop codon as one specific for Sec. The...

A Sequence-Specific RNA-Binding Protein Complements Apobec-1 To Edit Apolipoprotein B mRNA

Mehta, Anuradha, Driscoll, Donna M.

The editing of apolipoprotein B (apo-B) mRNA involves the site-specific deamination of cytidine to uracil. The specificity of editing is conferred by an 11-nucleotide mooring sequence located...

A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

Copeland, Paul R., Fletcher, Julia E., Carlson, Bradley A., Hatfield, Dolph L., Driscoll, Donna M.

In eukaryotes, the decoding of the UGA codon as selenocysteine (Sec) requires a Sec insertion sequence (SECIS) element in the 3′ untranslated region of the mRNA. We purified a SECIS binding...

Decoding apparatus for eukaryotic selenocysteine insertion

Tujebajeva, Rosa M., Copeland, Paul R., Xu, Xue-Ming, Carlson, Bradley A., Harney, John W., Driscoll, Donna M., ...

Decoding UGA as selenocysteine requires a unique tRNA, a specialized elongation factor, and specific secondary structures in the mRNA, termed SECIS elements. Eukaryotic SECIS elements are found in...

Finding needles in a haystack

Driscoll, Donna M., Chavatte, Laurent

In silico identification of eukaryotic selenoprotein genes

Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing.

Mehta, Anuradha, Driscoll, Donna M

The C-to-U editing of apolipoprotein-B (apo-B) mRNA is catalyzed by an enzyme complex that recognizes an 11-nt mooring sequence downstream of the editing site. A minimal holoenzyme that edits apo-B...

Molecular Cloning of Apobec-1 Complementation Factor, a Novel RNA-Binding Protein Involved in the Editing of Apolipoprotein B mRNA

Mehta, Anuradha, Kinter, Michael T., Sherman, Nicholas E., Driscoll, Donna M.

The C-to-U editing of apolipoprotein B (apo-B) mRNA is catalyzed by a multiprotein complex that recognizes an 11-nucleotide mooring sequence downstream of the editing site. The catalytic subunit of...

Insight into Mammalian Selenocysteine Insertion: Domain Structure and Ribosome Binding Properties of Sec Insertion Sequence Binding Protein 2

Copeland, Paul R., Stepanik, Vincent A., Driscoll, Donna M.

The cotranslational incorporation of the unusual amino acid selenocysteine (Sec) into both prokaryotic and eukaryotic proteins requires the recoding of a UGA stop codon as one specific for Sec. The...

A Sequence-Specific RNA-Binding Protein Complements Apobec-1 To Edit Apolipoprotein B mRNA

Mehta, Anuradha, Driscoll, Donna M.

The editing of apolipoprotein B (apo-B) mRNA involves the site-specific deamination of cytidine to uracil. The specificity of editing is conferred by an 11-nucleotide mooring sequence located...

A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

Copeland, Paul R., Fletcher, Julia E., Carlson, Bradley A., Hatfield, Dolph L., Driscoll, Donna M.

In eukaryotes, the decoding of the UGA codon as selenocysteine (Sec) requires a Sec insertion sequence (SECIS) element in the 3′ untranslated region of the mRNA. We purified a SECIS binding...

Decoding apparatus for eukaryotic selenocysteine insertion

Tujebajeva, Rosa M., Copeland, Paul R., Xu, Xue-Ming, Carlson, Bradley A., Harney, John W., Driscoll, Donna M., ...

Decoding UGA as selenocysteine requires a unique tRNA, a specialized elongation factor, and specific secondary structures in the mRNA, termed SECIS elements. Eukaryotic SECIS elements are found in...

Finding needles in a haystack

Driscoll, Donna M., Chavatte, Laurent

In silico identification of eukaryotic selenoprotein genes

Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing.

Mehta, Anuradha, Driscoll, Donna M

The C-to-U editing of apolipoprotein-B (apo-B) mRNA is catalyzed by an enzyme complex that recognizes an 11-nt mooring sequence downstream of the editing site. A minimal holoenzyme that edits apo-B...