Con A induced suppressor cells: Suppression with I region incompatibility (1977)
Dugan, Elizabeth, Niederhuber, John E., Frelinger, Jeffrey A., Mayo, Laura, Shreffler, Donald C.
Allogeneic Con A induced suppressor cells differing in the I and S region but not H-2K or H-2D regions were as efficient as syngeneic cells in suppressing the secondary IgM and IgG response to burro...
Niederhuber, John E., Frelinger, Jeffrey A., Dugan, Elizabeth, Shreffler, Donald C.
Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement...
Studies of the mixed lymphocyte reaction by the virus plaque assay (1975)
Kano, Shogo, Bloom, Barry R., Shreffler, Donald C., Schendel, Dolores, Bach, Fritz H.
The virus plaque assay has been developed as a tool for enumerating activated lymphocytes. In previous studies using mitogens it was found that the assay detects activated T- but not activated...
David, Chella S., Shreffler, Donald C., Stimpfling, Jack H.
Specificity H-2.7 is expressed predominantly on erythrocytes and controlled by a gene that maps within the H-2 gene complex at a locus, designated as H-2G , which apparently lies between regions S...
Schultz, Jane S., Frelinger, Jeffrey A., Kim, Sun-Kee, Shreffler, Donald C.
The distribution of Ia antigens on the surfaces of lymph node lymphocytes of several mouse strains was investigated using indirect immunoferritin labeling and electron microscopy. The immunoferritin...
Gasser, David L., Shreffler, Donald C.
Murine responses to both the male specific histocompatibility antigen H-Y and the erythrocyte alloantigen Ea-1 are regulated by genetic factors. In each case a single major gene that controls the...
Genetic nomenclature for the H-2 complex of the mouse (1974)
Klein, Jan, Shreffler, Donald C., Bach, Fritz H., McDevitt, H. O., Festenstein, F., Snell, G. D., ...
Peer Reviewed
Götze, Dietrich, David, Chella S., McDevitf, H., Klein, Jan, Sachs, D., Shreffler, Donald C.
Peer Reviewed
Shreffler, Donald C., Young, H., Nabholz, M., Meo, T., Rijnbeek, A., Miggiano, V.
B6.C-H-2 ba [H (z1)] is a mutant derived from C57BL/6. The two strains mutually reject their skingrafts and are incompatible in the mixed leucocyte reaction (MLR) and in cell-mediated lympholysis...
Shreffler, Donald C., Hansen, T. H., Krasteff, T. N.
A radial immunodiffusion assay for quantitation of the Ss and Slp serum antigens is described. Significant differences between the mean serum concentrations of Ss and Slp were found among various...
A sex-limited serum protein variant in the mouse: Hormonal control of phenotypic expression (1971)
Passmore, Howard C., Shreffler, Donald C.
The sex-limited protein (Slp) antigen of the mouse is first detected in the serum of strain DBA/2J males at 5–6 weeks of age and reaches full adult levels by 10 weeks. This antigen is normally...
Two new ceruloplasmin variants in Negroes—Data on three populations (1970)
Shreffler, Donald C., Shokeir, M. H. K.
Two new electrophoretic variants in human serum ceruloplasmin are described. The first, called Cp New Haven (CpNH), is determined by an allele at the same autosomal locus which controls the...
Shreffler, Donald C., Passmore, Howard C.
An alloantiserum produced in the mouse has been used to detect an antigen which is present only in male serum from certain inbred strains of mice, e.g., DBA/2J, A/J, and BALB/c. Genetic tests reveal...
The Seminole Indians of Florida: Morphology and serology (1970)
Pollitzer, William S., Rucknagel, Donald L., Tashian, Richard E., Shreffler, Donald C., Leyshon, Webster C., Namboodiri, Kadambari, ...
The Seminole Indians of Florida were studied on their three reservations for blood types, red cell enzymes, serum proteins, physical measurements, and relationships. Both serologic and morphologic...
Electrophoretic variation in human serum ceruloplasmin: A new genetic polymorphism (1967)
Shreffler, Donald C., Brewer, George J., Gall, John C., Honeyman, Merton S.
Through the application of a specific oxidase stain to results of starch gel electrophoresis of human serum, three different electrophoretic forms of ceruloplasmin—denoted CpA (fast), CpB...
Shreffler, Donald C., Hames, Curtis, Honeyman, Merton S., Brewer, George J., Gall, John C., Gershowitz, Henry, ...
Studies have been conducted on eight sets of monozygous and nine sets of dizygous female Negro twins, both members of whom were heterozygous for G-6-PD deficiency. Twins were studied both by assay of...
Parker, Keith L., Roos, Marleen H., Shreffler, Donald C.
The S region of the murine major histocompatibility complex controls the expression of two related, serum substance-positive proteins; one (C4) has functional complement activity, whereas the other,...
New Lymphocyte Antigen System (Lna) Controlled by the Ir Region of the Mouse H-2 Complex
David, C. S., Shreffler, Donald C., Frelinger, Jeffrey A.
A new system of lymphocyte alloantigens in mice is described. This Lna (lymph-node antigen) system is associated with the Ir region of the H-2 (histocompatibility-2) gene complex. It has the...
Parker, Keith L., Roos, Marleen H., Shreffler, Donald C.
The S region of the murine major histocompatibility complex controls the expression of two related, serum substance-positive proteins; one (C4) has functional complement activity, whereas the other,...
New Lymphocyte Antigen System (Lna) Controlled by the Ir Region of the Mouse H-2 Complex
David, C. S., Shreffler, Donald C., Frelinger, Jeffrey A.
A new system of lymphocyte alloantigens in mice is described. This Lna (lymph-node antigen) system is associated with the Ir region of the H-2 (histocompatibility-2) gene complex. It has the...
EVIDENCE SUPPORTING A TWO-GENE MODEL FOR THE H-2 HISTOCOMPATIBILITY SYSTEM OF THE MOUSE
Klein, Jan, Shreffler, Donald C.
The genetic structure of the H-2 system has been traditionally interpreted as consisting of multiple regions controlling histocompatibility antigens. Recently however, many difficulties have been...
GENETIC CONTROL OF THE IMMUNE RESPONSE : MAPPING OF THEIR-1 LOCUS
McDevitt, Hugh O., Deak, Beverly D., Shreffler, Donald C., Klein, Jan, Stimpfling, Jack H., Snell, George D.
Eleven strains of mice bearing recombinant H-2 chromosomes derived from known crossover events between known H-2 types were immunized with a series of branched, multichain, synthetic polypeptide...
EVIDENCE FOR THE EXPRESSION OF Ia (H-2-ASSOCIATED) ANTIGENS ON THYMUS-DERIVED LYMPHOCYTES
Frelinger, Jeffrey A., Niederhuber, John E., David, C. S., Shreffler, Donald C.
We have demonstrated in an anti-Ia serum the presence of specific antibodies reacting with T cells, as well as with B cells, using a highly sensitive dye exclusion test. This antiserum reacts with...