Dominique Langin

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. (2008)

Henegar, Corneliu, Tordjman, Joan, Achard, Vincent, Lacasa, Daniele, Cremer, Isabelle, Guerre-Millo, Michele, ...

ABSTRACT: BACKGROUND: Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in...

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. (2008)

Henegar, Corneliu, Tordjman, Joan, Achard, Vincent, Lacasa, Daniele, Cremer, Isabelle, Guerre-Millo, Michele, ...

ABSTRACT: BACKGROUND: Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in...

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008)

Henegar, Corneliu, Tordjman, Joan, Achard, Vincent, Lacasa, Danièle, Cremer, Isabelle, Guerre-Millo, Michèle, ...

Abstract Background Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly shown to be involved...

Cdk4 promotes adipogenesis through PPARgamma activation. (2007)

Abella, Anna, Dubus, Pierre, Malumbres, Marcos, Rane, Sushil G, Kiyokawa, Hiroaki, Sicard, Audrey, ...

Cell cycle regulators such as E2F1 and retinoblastoma (RB) play crucial roles in the control of adipogenesis, mostly by controlling the transition between preadipocyte proliferation and adipocyte...

Cdk4 promotes adipogenesis through PPARgamma activation. (2007)

Abella, Anna, Dubus, Pierre, Malumbres, Marcos, Rane, Sushil G, Kiyokawa, Hiroaki, Sicard, Audrey, ...

Cell cycle regulators such as E2F1 and retinoblastoma (RB) play crucial roles in the control of adipogenesis, mostly by controlling the transition between preadipocyte proliferation and adipocyte...

Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets (2006)

Philippe Boutin, Moira A. Taylor, Lesli H. Larsen, Camilla Verdich, Liselotte Petersen, ...

Objectives:To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic...

The case for strategic international alliances to harness nutritional genomics for public and personal health (2005)

Kaput, Jim, Ordovas, José, Ferguson, Lynnette, Van Ommen, Ben, Rodríguez, Raymond, Allen, Lindsay, ...

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into...

A novel hormone-sensitive lipase isoform expressed in pancreatic beta -cells. (2004)

Lindvall, Hakan, Nevsten, Pernilla, Strom, Kristoffer, Wallenberg, Reine, Sundler, Frank, Langin, Dominique, ...

Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization in many cell types. Two isoforms of HSL are known to date, namely HSLadi (84 kDa in rat) and HSLtes (130 kDa in rat). These...

In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone

Clément, Karine, Viguerie, Nathalie, Diehn, Maximilian, Alizadeh, Ash, Barbe, Pierre, Thalamas, Claire, ...

Thyroid hormones are key regulators of metabolism that modulate transcription via nuclear receptors. Hyperthyroidism is associated with increased metabolic rate, protein breakdown, and weight loss....

In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone

Clément, Karine, Viguerie, Nathalie, Diehn, Maximilian, Alizadeh, Ash, Barbe, Pierre, Thalamas, Claire, ...

Thyroid hormones are key regulators of metabolism that modulate transcription via nuclear receptors. Hyperthyroidism is associated with increased metabolic rate, protein breakdown, and weight loss....

Lipolytic effects of conventional β3-adrenoceptor agonists and of CGP 12,177 in rat and human fat cells : preliminary pharmacological evidence for a putative β4-adrenoceptor

Galitzky, Jean, Langin, Dominique, Verwaerde, Patrick, Montastruc, Jean-Louis, Lafontan, Max, Berlan, Michel

The nature of rat and human fat cell β3-adrenoceptors was investigated by studying the effects of the new β3-adrenoceptor selective antagonist, SR 59,230A, on lipolysis induced by the conventional...

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

Henegar, Corneliu, Tordjman, Joan, Achard, Vincent, Lacasa, Danièle, Cremer, Isabelle, Guerre-Millo, Michèle, ...

Analysis of the transcriptomic signature of white adipose tissue in obese human subjects revealed increased interstitial fibrosis and an infiltration of inflammatory cells into the tissue.