Lobanov, Alexey V., Fomenko, Dmitri E., Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L., Gladyshev, Vadim N.
Background: Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both eukaryotes and...
Lobanov, Alexey V, Fomenko, Dmitri E, Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L, Gladyshev, Vadim N
Abstract Background Selenocysteine (Sec) is a selenium-containing amino acid that is co-translationally inserted into nascent polypeptides by recoding UGA codons. Selenoproteins occur in both...
High-Throughput Identification of Catalytic Redox-Active Cysteine Residues (2007)
Fomenko, Dmitri E., Xing, Weibing, Adair, Blakely M., Thomas, David J., Gladyshev, Vadim
Cysteine (Cys) residues often play critical roles in proteins; however, identification of their specific functions has been limited to case-by-case experimental approaches. We developed a procedure...
Fomenko, Dmitri E., Xing, Weibing, Adair, Blakely M., Thomas, David J., Gladyshev, Vadim
Identification of redox-active Cys by homology to selenoproteins Identification of Cys/Sec pairsStatistical analysis of redox-active Cys neighborhoodsAdoMet-dependent methyltransferaseActivity of...
Ferguson, Andrew D., Labunskyy , Vyacheslav, Fomenko, Dmitri E., Arac, Demet, Chelliah, Yogarany, Amexcua, Carlos A., ...
Selenium has significant health benefits, including potent cancer prevention activity and roles in immune function and the male reproductive system. Selenium-containing proteins, which incorporate...
Labunskyy, Vyacheslav M., Ferguson, Andrew D., Fomenko, Dmitri E., Chelliah, Yogarany, Hatfield, Dolph L., Gladyshev, Vadim N.
Selenium is an essential trace element with potent cancer prevention activity in mammals. The 15-kDa selenoprotein (Sep15) has been implicated in the chemopreventive effect of dietary selenium....
The microbial selenoproteome of the Sargasso Sea (2005)
Zhang, Yan, Fomenko, Dmitri E, Gladyshev, Vadim N
Abstract Background Selenocysteine (Sec) is a rare amino acid which occurs in proteins in major domains of life. It is encoded by TGA, which also serves as the signal for termination of translation,...
The microbial selenoproteome of the Sargasso Sea (2005)
Zhang, Yan, Fomenko, Dmitri E., Gladyshev, Vadim
Background: Selenocysteine (Sec) is a rare amino acid which occurs in proteins in major domains of life. It is encoded by TGA, which also serves as the signal for termination of translation,...
New Techniques for Generation and Analysis (2004)
Chang Wang, Stephen D. Scott, Qingping Tao, Dmitri E. Fomenko, Vadim N. Gladyshev
We introduce new distance measures for the construction and analysis of phylogenies, focusing on thioredoxin-fold proteins. Our distance measures for tree construction are based on several criteria,...
Microcin C51 Plasmid Genes: Possible Source of Horizontal Gene Transfer
Fomenko, Dmitri E., Metlitskaya, Anastazia Z., Péduzzi, Jean, Goulard, Christophe, Katrukha, Genrikh S., Gening, Leonid V., ...
Microcin C51 (MccC51) is an antimicrobial nucleotide-heptapeptide produced by a natural Escherichia coli strain. A 5.7-kb fragment of the pC51 plasmid carrying the genes involved in MccC51...
The microbial selenoproteome of the Sargasso Sea
Zhang, Yan, Fomenko, Dmitri E, Gladyshev, Vadim N
An analysis of the selenoproteome of the largest microbial sequence dataset, the Sargasso Sea environmental genome sequences, identified 310 selenoprotein genes that clustered into 25 families. This...
Microcin C51 Plasmid Genes: Possible Source of Horizontal Gene Transfer
Fomenko, Dmitri E., Metlitskaya, Anastazia Z., Péduzzi, Jean, Goulard, Christophe, Katrukha, Genrikh S., Gening, Leonid V., ...
Microcin C51 (MccC51) is an antimicrobial nucleotide-heptapeptide produced by a natural Escherichia coli strain. A 5.7-kb fragment of the pC51 plasmid carrying the genes involved in MccC51...
The microbial selenoproteome of the Sargasso Sea
Zhang, Yan, Fomenko, Dmitri E, Gladyshev, Vadim N
An analysis of the selenoproteome of the largest microbial sequence dataset, the Sargasso Sea environmental genome sequences, identified 310 selenoprotein genes that clustered into 25 families. This...
Lobanov, Alexey V, Fomenko, Dmitri E, Zhang, Yan, Sengupta, Aniruddha, Hatfield, Dolph L, Gladyshev, Vadim N
In silico and metabolic labeling studies of the selenoproteomes of several eukaryotes revealed distinct selenoprotein patterns as well as an ancient origin of selenoproteins and massive, independent...