Dimitry S. A. Nuyten

Determination of Stromal Signatures in Breast Carcinoma

West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, Jen-Tsan, Wang, Zhen, Nuyten, Dimitry S. A, Rodriguez, Edwin H, Schaner, Marci E, Salim, Ali, ...

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and...

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

Chang, Howard Y., Nuyten, Dimitry S. A., Sneddon, Julie B., Hastie, Trevor, Tibshirani, Robert, Sørlie, Therese, ...

Based on the hypothesis that features of the molecular program of normal wound healing might play an important role in cancer metastasis, we previously identified consistent features in the...

Determination of Stromal Signatures in Breast Carcinoma

West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, Jen-Tsan, Wang, Zhen, Nuyten, Dimitry S. A, Rodriguez, Edwin H, Schaner, Marci E, Salim, Ali, ...

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and...

Gene Expression Programs of Human Smooth Muscle Cells: Tissue-Specific Differentiation and Prognostic Significance in Breast Cancers

Chi, Jen-Tsan, Rodriguez, Edwin H, Wang, Zhen, Nuyten, Dimitry S. A, Mukherjee, Sayan, Van De Rijn, Matt, ...

Smooth muscle is present in a wide variety of anatomical locations, such as blood vessels, various visceral organs, and hair follicles. Contraction of smooth muscle is central to functions as diverse...

The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans

Welm, Alana L., Sneddon, Julie B., Taylor, Carmen, Nuyten, Dimitry S. A., Van De Vijver, Marc J., Hasegawa, Bruce H., ...

A better understanding of tumor metastasis requires development of animal models that authentically reproduce the metastatic process. By modifying an existing mouse model of breast cancer, we...