Nishida, Noriyuki, Harris, David A., Vilette, Didier, Laude, Hubert, Frobert, Yveline, Grassi, Jacques, ...
Propagation of the agents responsible for transmissible spongiform encephalopathies (TSEs) in cultured cells has been achieved for only a few cell lines. To establish efficient and versatile models...
Markedly Increased Susceptibility to Natural Sheep Scrapie of Transgenic Mice Expressing Ovine PrP
Vilotte, Jean-Luc, Soulier, Solange, Essalmani, Rachid, Stinnakre, Marie-George, Vaiman, Daniel, Lepourry, Laurence, ...
The susceptibility of sheep to scrapie is known to involve, as a major determinant, the nature of the prion protein (PrP) allele, with the VRQ allele conferring the highest susceptibility to the...
PrP Polymorphisms Tightly Control Sheep Prion Replication in Cultured Cells
Sabuncu, Elifsu, Petit, Stéphanie, Le Dur, Annick, Lan Lai, Thanh, Vilotte, Jean-Luc, Laude, Hubert, ...
Prion diseases are fatal neurodegenerative disorders of animals and humans that are characterized by the conversion of the host-encoded prion protein (PrP) to an abnormal isoform. In several species,...
Cultured Peripheral Neuroglial Cells Are Highly Permissive to Sheep Prion Infection
Archer, Fabienne, Bachelin, Corinne, Andreoletti, Olivier, Besnard, Nathalie, Perrot, Gregory, Langevin, Christelle, ...
Transmissible spongiform encephalopathies arise as a consequence of infection of the central nervous system (CNS) by prions. Spreading of the infectious agent through the peripheral nervous system...
Prion Infection of Epithelial Rov Cells Is a Polarized Event
Paquet, Sophie, Sabuncu, Elifsu, Delaunay, Jean-Louis, Laude, Hubert, Vilette, Didier
During prion infections, the cellular glycosylphosphatidylinositol-anchored glycoprotein PrP is converted into a conformational isoform. This abnormal conformer is thought to recruit and convert the...
Cells release prions in association with exosomes
Fevrier, Benoit, Vilette, Didier, Archer, Fabienne, Loew, Damarys, Faigle, Wolfgang, Vidal, Michel, ...
Prion diseases are infectious neurodegenerative disorders linked to the accumulation in the central nervous system of the abnormally folded prion protein (PrP) scrapie (PrPsc), which is thought to be...
Nishida, Noriyuki, Harris, David A., Vilette, Didier, Laude, Hubert, Frobert, Yveline, Grassi, Jacques, ...
Propagation of the agents responsible for transmissible spongiform encephalopathies (TSEs) in cultured cells has been achieved for only a few cell lines. To establish efficient and versatile models...
Markedly Increased Susceptibility to Natural Sheep Scrapie of Transgenic Mice Expressing Ovine PrP
Vilotte, Jean-Luc, Soulier, Solange, Essalmani, Rachid, Stinnakre, Marie-George, Vaiman, Daniel, Lepourry, Laurence, ...
The susceptibility of sheep to scrapie is known to involve, as a major determinant, the nature of the prion protein (PrP) allele, with the VRQ allele conferring the highest susceptibility to the...
PrP Polymorphisms Tightly Control Sheep Prion Replication in Cultured Cells
Sabuncu, Elifsu, Petit, Stéphanie, Le Dur, Annick, Lan Lai, Thanh, Vilotte, Jean-Luc, Laude, Hubert, ...
Prion diseases are fatal neurodegenerative disorders of animals and humans that are characterized by the conversion of the host-encoded prion protein (PrP) to an abnormal isoform. In several species,...
Cultured Peripheral Neuroglial Cells Are Highly Permissive to Sheep Prion Infection
Archer, Fabienne, Bachelin, Corinne, Andreoletti, Olivier, Besnard, Nathalie, Perrot, Gregory, Langevin, Christelle, ...
Transmissible spongiform encephalopathies arise as a consequence of infection of the central nervous system (CNS) by prions. Spreading of the infectious agent through the peripheral nervous system...
Prion Infection of Epithelial Rov Cells Is a Polarized Event
Paquet, Sophie, Sabuncu, Elifsu, Delaunay, Jean-Louis, Laude, Hubert, Vilette, Didier
During prion infections, the cellular glycosylphosphatidylinositol-anchored glycoprotein PrP is converted into a conformational isoform. This abnormal conformer is thought to recruit and convert the...
Cells release prions in association with exosomes
Fevrier, Benoit, Vilette, Didier, Archer, Fabienne, Loew, Damarys, Faigle, Wolfgang, Vidal, Michel, ...
Prion diseases are infectious neurodegenerative disorders linked to the accumulation in the central nervous system of the abnormally folded prion protein (PrP) scrapie (PrPsc), which is thought to be...
Paquet, Sophie, Daude, Nathalie, Courageot, Marie-Pierre, Chapuis, Jérôme, Laude, Hubert, Vilette, Didier
We have studied the interactions of exogenous prions with an epithelial cell line inducibly expressing PrPc protein and permissive to infection by a sheep scrapie agent. We demonstrate that abnormal...