Diana L. Wallace

Prolonged exposure of naïve CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length

Wallace, Diana L, Bérard, Marion, Soares, Maria V D, Oldham, Janine, Cook, Joanne E, Akbar, Arne N, ...

Interleukin (IL)-7 and IL-15 are cytokines implicated in homeostatic control of the peripheral CD8 T-cell pool. We compared the effects of IL-7 and IL-15 on survival and proliferation of purified...

In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection

Asquith, Becca, Zhang, Yan, Mosley, Angelina J., De Lara, Catherine M., Wallace, Diana L., Worth, Andrew, ...

Human T-lymphotropic virus type 1 (HTLV-1) is a persistent CD4+ T-lymphotropic retrovirus. Most HTLV-1-infected individuals remain asymptomatic, but a proportion develop adult T cell leukemia or...

In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection

Zhang, Yan, Wallace, Diana L, De Lara, Catherine M, Ghattas, Hala, Asquith, Becca, Worth, Andrew, ...

Human natural killer (NK) cells form a circulating population in a state of dynamic homeostasis. We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium-enriched...