Derek C. Macallan

Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies in vitro, in animals, and in humans

Macallan, Derek C., Fullerton, Catherine A., Neese, Richard A., Haddock, Katherine, Park, Sunny S., Hellerstein, Marc K.

A method for measuring DNA synthesis and, thus, cell proliferation, in vivo is presented. The technique consists of administering [6,6-2H2]Glc or [U-13C]Glc, isolating genomic DNA, hydrolyzing...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+CD45RO+CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies in vitro, in animals, and in humans

Macallan, Derek C., Fullerton, Catherine A., Neese, Richard A., Haddock, Katherine, Park, Sunny S., Hellerstein, Marc K.

A method for measuring DNA synthesis and, thus, cell proliferation, in vivo is presented. The technique consists of administering [6,6-2H2]Glc or [U-13C]Glc, isolating genomic DNA, hydrolyzing...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+CD45RO+CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection

Asquith, Becca, Zhang, Yan, Mosley, Angelina J., De Lara, Catherine M., Wallace, Diana L., Worth, Andrew, ...

Human T-lymphotropic virus type 1 (HTLV-1) is a persistent CD4+ T-lymphotropic retrovirus. Most HTLV-1-infected individuals remain asymptomatic, but a proportion develop adult T cell leukemia or...

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

Macallan, Derek C., Wallace, Diana, Zhang, Yan, De Lara, Catherine, Worth, Andrew T., Ghattas, Hala, ...

Memory T cells can be divided into central–memory (TCM) and effector–memory (TEM) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not...

In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection

Zhang, Yan, Wallace, Diana L, De Lara, Catherine M, Ghattas, Hala, Asquith, Becca, Worth, Andrew, ...

Human natural killer (NK) cells form a circulating population in a state of dynamic homeostasis. We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium-enriched...