Reade, Michael C, Delaney, Anthony, Bailey, Michael J, Angus, Derek C
Abstract Meta-analysis can be a powerful tool for demonstrating the applicability of a concept beyond the context of individual clinical trials and observational studies, including exploration of...
Bench-to-bedside review: The evaluation of complex interventions in critical care (2008)
Delaney, Anthony, Angus, Derek C, Bellomo, Rinaldo, Cameron, Peter, Cooper, D James, Finfer, Simon, ...
Abstract Complex interventions, such as the introduction of medical emergency teams or an early goal-directed therapy protocol, are developed from a number of components that may act both...
Saka, Görkem, Kreke, Jennifer E, Schaefer, Andrew J, Chang, Chung-Chou H, Roberts, Mark S, Angus, Derek C, ...
Abstract Introduction Sepsis is the leading cause of death in critically ill patients and often affects individuals with community-acquired pneumonia. To overcome the limitations of earlier...
Milbrandt, Eric B, Angus, Derek C
Abstract Cognitive dysfunction is common in critically ill patients, not only during the acute illness but also long after its resolution. A large number of pathophysiologic mechanisms are thought to...
Yende, Sachin, Kammerer, Candace M, Angus, Derek C
Abstract There is considerable interest in understanding genetic determinants of critical illness to improve current risk stratification models, provide individualized therapies, and improve our...
Hoste, Eric AJ, Clermont, Gilles, Kersten, Alexander, Venkataraman, Ramesh, Angus, Derek C, De Bacquer, Dirk, ...
Abstract Introduction The lack of a standard definition for acute kidney injury has resulted in a large variation in the reported incidence and associated mortality. RIFLE, a newly developed...
Predicting late anemia in critical illness (2006)
Milbrandt, Eric B, Clermont, Gilles, Martinez, Javier, Kersten, Alex, Rahim, Malik T, Angus, Derek C
Abstract Introduction Identifying critically ill patients most likely to benefit from pre-emptive therapies will become increasingly important if therapies are to be used safely and cost-effectively....
PAC-Man: Game over for the pulmonary artery catheter? (2006)
Reade, Michael C, Angus, Derek C
No abstract available.
Hadian, Mehrnaz, Angus, Derek C
No abstract available.
Severe sepsis epidemiology: sampling, selection, and society (2004)
Linde-Zwirble, Walter T, Angus, Derek C
Abstract Three new articles in Critical Care add to an expanding body of information on the epidemiology of severe sepsis. Although there have been a range of approaches to estimate the incidence of...
Understanding the lingering consequences of what we treat and what we do (2004)
Abstract Granja and colleagues have helped us by showing that long-term follow-up is feasible and by trying to tease out whether select intensive care unit patient populations are at particular risk...
The PIRO concept: P is for predisposition (2003)
Angus, Derek C, Burgner, David, Wunderink, Richard, Mira, Jean-Paul, Gerlach, Herwig, Wiedermann, Christian J, ...
No abstract available.
Variation in sepsis care: a wake-up call (2003)
Hartman, Mary E, Angus, Derek C
Abstract There is important variation in the care of critically ill patients. While some of this variability is appropriate, and represents individually titrated care, residual variation indicates...
Translating research evidence into clinical practice: new challenges for critical care (2002)
Kalassian, Kenneth G, Dremsizov, Tony, Angus, Derek C
Abstract High quality research evidence is now available to guide and shape the practice of critical care. As the generation of such evidence increases, the challenge facing critical care medicine...
Translating research evidence into clinical practice: new challenges for critical care
Kalassian, Kenneth G, Dremsizov, Tony, Angus, Derek C
High quality research evidence is now available to guide and shape the practice of critical care. As the generation of such evidence increases, the challenge facing critical care medicine will be...
Variation in sepsis care: a wake-up call
Hartman, Mary E, Angus, Derek C
There is important variation in the care of critically ill patients. While some of this variability is appropriate, and represents individually titrated care, residual variation indicates over- and...
The PIRO concept: P is for predisposition
Angus, Derek C, Burgner, David, Wunderink, Richard, Mira, Jean-Paul, Gerlach, Herwig, Wiedermann, Christian J, ...
Understanding the lingering consequences of what we treat and what we do
Granja and colleagues have helped us by showing that long-term follow-up is feasible and by trying to tease out whether select intensive care unit patient populations are at particular risk of...
Severe sepsis epidemiology: sampling, selection, and society
Linde-Zwirble, Walter T, Angus, Derek C
Three new articles in Critical Care add to an expanding body of information on the epidemiology of severe sepsis. Although there have been a range of approaches to estimate the incidence of severe...
Predicting late anemia in critical illness
Milbrandt, Eric B, Clermont, Gilles, Martinez, Javier, Kersten, Alex, Rahim, Malik T, Angus, Derek C
Hoste, Eric AJ, Clermont, Gilles, Kersten, Alexander, Venkataraman, Ramesh, Angus, Derek C, De Bacquer, Dirk, ...
Translating research evidence into clinical practice: new challenges for critical care
Kalassian, Kenneth G, Dremsizov, Tony, Angus, Derek C
High quality research evidence is now available to guide and shape the practice of critical care. As the generation of such evidence increases, the challenge facing critical care medicine will be...
Variation in sepsis care: a wake-up call
Hartman, Mary E, Angus, Derek C
There is important variation in the care of critically ill patients. While some of this variability is appropriate, and represents individually titrated care, residual variation indicates over- and...
The PIRO concept: P is for predisposition
Angus, Derek C, Burgner, David, Wunderink, Richard, Mira, Jean-Paul, Gerlach, Herwig, Wiedermann, Christian J, ...
Understanding the lingering consequences of what we treat and what we do
Granja and colleagues have helped us by showing that long-term follow-up is feasible and by trying to tease out whether select intensive care unit patient populations are at particular risk of...
Severe sepsis epidemiology: sampling, selection, and society
Linde-Zwirble, Walter T, Angus, Derek C
Three new articles in Critical Care add to an expanding body of information on the epidemiology of severe sepsis. Although there have been a range of approaches to estimate the incidence of severe...
Predicting late anemia in critical illness
Milbrandt, Eric B, Clermont, Gilles, Martinez, Javier, Kersten, Alex, Rahim, Malik T, Angus, Derek C
Hoste, Eric AJ, Clermont, Gilles, Kersten, Alexander, Venkataraman, Ramesh, Angus, Derek C, De Bacquer, Dirk, ...
Yende, Sachin, Kammerer, Candace M, Angus, Derek C
There is considerable interest in understanding genetic determinants of critical illness to improve current risk stratification models, provide individualized therapies, and improve our current...
Milbrandt, Eric B, Angus, Derek C
Cognitive dysfunction is common in critically ill patients, not only during the acute illness but also long after its resolution. A large number of pathophysiologic mechanisms are thought to underlie...
Informal Caregiver Burden among Survivors of Prolonged Mechanical Ventilation
Van Pelt, David C., Milbrandt, Eric B., Qin, Li, Weissfeld, Lisa A., Rotondi, Armando J., Schulz, Richard, ...
Rationale: Although caregiver burden is well described in chronic illness, few studies have examined burden among caregivers of survivors of critical illness. In existing studies, it is unclear...
Saka, Görkem, Kreke, Jennifer E, Schaefer, Andrew J, Chang, Chung-Chou H, Roberts, Mark S, Angus, Derek C
Dellinger, R. Phillip, Levy, Mitchell M., Carlet, Jean M., Bion, Julian, Parker, Margaret M., Jaeschke, Roman, ...
Pharmacoeconomic Implications of New Therapies in Sepsis
Severe sepsis is a major healthcare problem, characterised by a high incidence, mortality and cost. New breakthroughs in treatment are quite diverse, including: (i) more effective regimens for...
Bench-to-bedside review: The evaluation of complex interventions in critical care
Delaney, Anthony, Angus, Derek C, Bellomo, Rinaldo, Cameron, Peter, Cooper, D James, Finfer, Simon, ...
Complex interventions, such as the introduction of medical emergency teams or an early goal-directed therapy protocol, are developed from a number of components that may act both independently and...
Reade, Michael C, Delaney, Anthony, Bailey, Michael J, Angus, Derek C
Meta-analysis can be a powerful tool for demonstrating the applicability of a concept beyond the context of individual clinical trials and observational studies, including exploration of effects...