Deqiang Zhang

The association of tetrameric acetylcholinesterase with CoIQ tail: A block normal mode analysis (2005)

Zhang, Deqiang, McCammon, J Andrew

Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. In physiological conditions, AChE exists...

The Association of Tetrameric Acetylcholinesterase with ColQ Tail: A Block Normal Mode Analysis (2005)

Deqiang Zhang, J. Andrew McCammon

Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. In physiological conditions, AChE exists...

The Association of Tetrameric Acetylcholinesterase With ColQ Tail: A Block Normal Mode Analysis (2005)

Deqiang Zhang

Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. In physiological conditions, AChE exists...

Structure-based design of mutant proteins: I. Molecular docking studies of amino acid binding to wild-type aminoacyl-tRNA synthetases. II. Structure-based design of mutant aminoacyl-tRNA synthetases for non-natural amino acid incorporation (2002)

Zhang, Deqiang

Protein biosynthesis has precisely controlled accuracy, and aminoacyl-tRNA synthetases (AARSs) play an important role in charging amino acids to their cognate tRNAs with high fidelity. In some cases...

Structure-based design of mutant proteins: I. Molecular docking studies of amino acid binding to wild-type aminoacyl-tRNA synthetases. II. Structure-based design of mutant aminoacyl-tRNA synthetases for non-natural amino acid incorporation (2002)

Zhang, Deqiang

Protein biosynthesis has precisely controlled accuracy, and aminoacyl-tRNA synthetases (AARSs) play an important role in charging amino acids to their cognate tRNAs with high fidelity. In some cases...

Femtosecond dynamics of rubredoxin: Tryptophan solvation and resonance energy transfer in the protein (2002)

Zhong, Dongping, Pal, Sumir Kumar, Zhang, Deqiang, Chan, Sunney I., Zewail, Ahmed H.

We report here studies of tryptophan (Trp) solvation dynamics in water and in the Pyrococcus furiosus rubredoxin protein, including the native and its apo and denatured forms. We also report results...

Femtosecond dynamics of rubredoxin: Tryptophan solvation and resonance energy transfer in the protein

Zhong, Dongping, Pal, Samir Kumar, Zhang, Deqiang, Chan, Sunney I., Zewail, Ahmed H.

We report here studies of tryptophan (Trp) solvation dynamics in water and in the Pyrococcus furiosus rubredoxin protein, including the native and its apo and denatured forms. We also report results...

Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-l-tyrosine

Zhang, Deqiang, Vaidehi, Nagarajan, Goddard, William A., Danzer, Joseph F., Debe, Derek

Although incorporation of amino acid analogs provides a powerful means of producing new protein structures with interesting functions, many amino acid analogs cannot be incorporated easily by using...

The Association of Tetrameric Acetylcholinesterase with ColQ Tail: A Block Normal Mode Analysis

Zhang, Deqiang, McCammon, J. Andrew

Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. In physiological conditions, AChE exists...

Tetrameric Mouse Acetylcholinesterase: Continuum Diffusion Rate Calculations by Solving the Steady-State Smoluchowski Equation Using Finite Element Methods

Zhang, Deqiang, Suen, Jason, Zhang, Yongjie, Song, Yuhua, Radic, Zoran, Taylor, Palmer, ...

The tetramer is the most important form for acetylcholinesterase in physiological conditions, i.e., in the neuromuscular junction and the nervous system. It is important to study the diffusion of...

Femtosecond dynamics of rubredoxin: Tryptophan solvation and resonance energy transfer in the protein

Zhong, Dongping, Pal, Samir Kumar, Zhang, Deqiang, Chan, Sunney I., Zewail, Ahmed H.

We report here studies of tryptophan (Trp) solvation dynamics in water and in the Pyrococcus furiosus rubredoxin protein, including the native and its apo and denatured forms. We also report results...

Structure-based design of mutant Methanococcus jannaschii tyrosyl-tRNA synthetase for incorporation of O-methyl-l-tyrosine

Zhang, Deqiang, Vaidehi, Nagarajan, Goddard, William A., Danzer, Joseph F., Debe, Derek

Although incorporation of amino acid analogs provides a powerful means of producing new protein structures with interesting functions, many amino acid analogs cannot be incorporated easily by using...

The Association of Tetrameric Acetylcholinesterase with ColQ Tail: A Block Normal Mode Analysis

Zhang, Deqiang, McCammon, J. Andrew

Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. In physiological conditions, AChE exists...

Tetrameric Mouse Acetylcholinesterase: Continuum Diffusion Rate Calculations by Solving the Steady-State Smoluchowski Equation Using Finite Element Methods

Zhang, Deqiang, Suen, Jason, Zhang, Yongjie, Song, Yuhua, Radic, Zoran, Taylor, Palmer, ...

The tetramer is the most important form for acetylcholinesterase in physiological conditions, i.e., in the neuromuscular junction and the nervous system. It is important to study the diffusion of...

Selectivity and specificity of substrate binding in methionyl-tRNA synthetase

Datta, Deepshikha, Vaidehi, Nagarajan, Zhang, Deqiang, Goddard, William A.

The accuracy of in vivo incorporation of amino acids during protein biosynthesis is controlled to a significant extent by aminoacyl-tRNA synthetases (aaRS). This paper describes the application of...

Finite Element Analysis of the Time-Dependent Smoluchowski Equation for Acetylcholinesterase Reaction Rate Calculations

Cheng, Yuhui, Suen, Jason K., Zhang, Deqiang, Bond, Stephen D., Zhang, Yongjie, Song, Yuhua, ...

This article describes the numerical solution of the time-dependent Smoluchowski equation to study diffusion in biomolecular systems. Specifically, finite element methods have been developed to...