Deborah L. Hodge

Regulation of Nuclear Gamma Interferon Gene Expression by Interleukin 12 (IL-12) and IL-2 Represents a Novel Form of Posttranscriptional Control

Hodge, Deborah L., Martinez, Alfredo, Julias, John G., Taylor, Lynn S., Young, Howard A.

Posttranscriptional control of gamma interferon (IFN-γ) gene expression has not been extensively studied and is poorly understood. Our work describes a posttranscriptional mechanism that modulates...

Regulation of Nuclear Gamma Interferon Gene Expression by Interleukin 12 (IL-12) and IL-2 Represents a Novel Form of Posttranscriptional Control

Hodge, Deborah L., Martinez, Alfredo, Julias, John G., Taylor, Lynn S., Young, Howard A.

Posttranscriptional control of gamma interferon (IFN-γ) gene expression has not been extensively studied and is poorly understood. Our work describes a posttranscriptional mechanism that modulates...

Regulation of ITAM-positive receptors: role of IL-12 and IL-18

Ortaldo, John R., Winkler-Pickett, Robin, Wigginton, Jon, Horner, Meagan, Bere, Earl W., Mason, Anna T., ...

Our previous studies have identified mechanisms by which cytokine production, blocked by Ly49G2 receptor cross-linking, can be overridden. In this study we analyzed the regulation of other...

Hematopoiesis and Thymic Apoptosis Are Not Affected by the Loss of Cdk2▿

Berthet, Cyril, Rodriguez-Galan, Maria Cecilia, Hodge, Deborah L., Gooya, John, Pascal, Véronique, Young, Howard A., ...

Cell cycle regulation is essential for proper homeostasis of hematopoietic cells. Cdk2 is a major regulator of S phase entry, is activated by mitogenic cytokines, and has been suggested to be...