Transcriptome analysis for Caenorhabditis elegansbased on novel expressed sequence tags (2008)
Shin, Heesun, Hirst, Martin, Bainbridge, Matthew N, Magrini, Vincent, Mardis, Elaine, Moerman, Donald G, ...
Abstract Background We have applied a high-throughput pyrosequencing technology for transcriptome profiling of Caenorhabditis elegans in its first larval stage. Using this approach, we have generated...
Jones, Martin R, Maydan, Jason S, Flibotte, Stephane, Moerman, Donald G, Baillie, David L
Abstract Background: A collection of genetic deficiencies covering over 70% of the Caenorhabditis elegans genome exists, however the application of these valuable biological tools has been limited...
High-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans (2007)
Rebecca Hunt-Newbury, Ryan Viveiros, Robert Johnsen, Allan Mah, Dina Anastas, Lily Fang, ...
Using DNA sequences 5′ to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in...
Chen, Nansheng, Mah, Allan, Blacque, Oliver E, Chu, Jeffrey, Phgora, Kiran, Bakhoum, Mathieu W, ...
Abstract Background The recent availability of genome sequences of multiple related Caenorhabditis species has made it possible to identify, using comparative genomics, similarly transcribed genes in...
Functional characterization in Caenorhabditis elegansof transmembrane worm-human orthologs (2004)
Henricson, Anna, Sonnhammer, Erik LL, Baillie, David L, Gomes, Ana
Abstract Background The complete genome sequences for human and the nematode Caenorhabditis elegans offer an opportunity to learn more about human gene function through functional characterization of...
Sheps, Jonathan A, Ralph, Steven, Zhao, Zhongying, Baillie, David L, Ling, Victor
Abstract Background Many drugs of natural origin are hydrophobic and can pass through cell membranes. Hydrophobic molecules must be susceptible to active efflux systems if they are to be maintained...
Grishok, Alla, Pasquinelli, Amy E., Conte, Darryl, Li, Na, Parrish, Susan, Ha, Ilho, ...
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis elegans, lin-4 and...
Thacker, Colin, Marra, Marco A., Jones, Alana, Baillie, David L., Rose, Ann M.
Comparative genomic analysis was used to investigate the gene structure of the bli-4 locus from two related Caenorhabditis species, C. elegans and C. briggsae. In C. elegans, bli-4 is a complex gene...
Sheps, Jonathan A, Ralph, Steven, Zhao, Zhongying, Baillie, David L, Ling, Victor
The ABC transporters in the Caenorhabditis elegans genome have been identified and characterized. Phylogenetic analysis shows a large amount of gene loss and duplication, which is unusual for such a...
Blacque, Oliver E., Reardon, Michael J., Li, Chunmei, McCarthy, Jonathan, Mahjoub, Moe R., Ansley, Stephen J., ...
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous developmental disorder whose molecular basis is largely unknown. Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8...
Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs
Henricson, Anna, Sonnhammer, Erik LL, Baillie, David L, Gomes, Ana Vaz
Identification of a nematode chemosensory gene family
Chen, Nansheng, Pai, Shraddha, Zhao, Zhongying, Mah, Allan, Newbury, Rebecca, Johnsen, Robert C., ...
Taking advantage of the recent availability of the whole genome sequence of Caenorhabditis briggsae, a closely related nematode to Caenorhabditis elegans, we have examined the chemosensory gene...
Essential Genes and Deficiencies in the UNC-22 IV Region of CAENORHABDITIS ELEGANS
Rogalski, Teresa M., Moerman, Donald G., Baillie, David L.
Five formaldehyde-induced deficiencies that uncover unc-22 IV, a gene affecting muscle structure in the nematode Caenorhabditis elegans were isolated and positioned. The largest deficiency, sDf2,...
The Genetic Analysis of a Reciprocal Translocation, eT1(III; V), in CAENORHABDITIS ELEGANS
Rosenbluth, Raja E., Baillie, David L.
The Caenorhabditis elegans mutation e873, which results in a recessive uncoordinated phenotype (formerly named Unc-72) and which had been isolated after 32P treatment (Brenner 1974), has now been...
Rosenbluth, Raja E., Cuddeford, Cheryl, Baillie, David L.
We previously established a γ-ray dose-response curve for recessive lethal events (lethals) captured over the eT1 balancer. In this paper we analyze the nature of lethal events produced, with a...
Maciejowski, John, Ahn, James Hyungsoo, Cipriani, Patricia Giselle, Killian, Darrell J., Chaudhary, Aisha L., Lee, Ji Inn, ...
We report molecular genetic studies of three genes involved in early germ-line proliferation in Caenorhabditis elegans that lend unexpected insight into a germ-line/soma functional separation of...
Thacker, Colin, Marra, Marco A., Jones, Alana, Baillie, David L., Rose, Ann M.
Comparative genomic analysis was used to investigate the gene structure of the bli-4 locus from two related Caenorhabditis species, C. elegans and C. briggsae. In C. elegans, bli-4 is a complex gene...
Sheps, Jonathan A, Ralph, Steven, Zhao, Zhongying, Baillie, David L, Ling, Victor
The ABC transporters in the Caenorhabditis elegans genome have been identified and characterized. Phylogenetic analysis shows a large amount of gene loss and duplication, which is unusual for such a...
Blacque, Oliver E., Reardon, Michael J., Li, Chunmei, McCarthy, Jonathan, Mahjoub, Moe R., Ansley, Stephen J., ...
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous developmental disorder whose molecular basis is largely unknown. Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8...
Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs
Henricson, Anna, Sonnhammer, Erik LL, Baillie, David L, Gomes, Ana Vaz
Identification of a nematode chemosensory gene family
Chen, Nansheng, Pai, Shraddha, Zhao, Zhongying, Mah, Allan, Newbury, Rebecca, Johnsen, Robert C., ...
Taking advantage of the recent availability of the whole genome sequence of Caenorhabditis briggsae, a closely related nematode to Caenorhabditis elegans, we have examined the chemosensory gene...
Essential Genes and Deficiencies in the UNC-22 IV Region of CAENORHABDITIS ELEGANS
Rogalski, Teresa M., Moerman, Donald G., Baillie, David L.
Five formaldehyde-induced deficiencies that uncover unc-22 IV, a gene affecting muscle structure in the nematode Caenorhabditis elegans were isolated and positioned. The largest deficiency, sDf2,...
The Genetic Analysis of a Reciprocal Translocation, eT1(III; V), in CAENORHABDITIS ELEGANS
Rosenbluth, Raja E., Baillie, David L.
The Caenorhabditis elegans mutation e873, which results in a recessive uncoordinated phenotype (formerly named Unc-72) and which had been isolated after 32P treatment (Brenner 1974), has now been...
Rosenbluth, Raja E., Cuddeford, Cheryl, Baillie, David L.
We previously established a γ-ray dose-response curve for recessive lethal events (lethals) captured over the eT1 balancer. In this paper we analyze the nature of lethal events produced, with a...
Maciejowski, John, Ahn, James Hyungsoo, Cipriani, Patricia Giselle, Killian, Darrell J., Chaudhary, Aisha L., Lee, Ji Inn, ...
We report molecular genetic studies of three genes involved in early germ-line proliferation in Caenorhabditis elegans that lend unexpected insight into a germ-line/soma functional separation of...
The WD Repeat-containing Protein IFTA-1 Is Required for Retrograde Intraflagellar Transport
Blacque, Oliver E., Li, Chunmei, Inglis, Peter N., Esmail, Muneer A., Ou, Guangshuo, Mah, Allan K., ...
The assembly and maintenance of cilia require intraflagellar transport (IFT), a microtubule-dependent bidirectional motility of multisubunit protein complexes along ciliary axonemes. Defects in IFT...
Chen, Nansheng, Mah, Allan, Blacque, Oliver E, Chu, Jeffrey, Phgora, Kiran, Bakhoum, Mathieu W, ...
Comparative genomic analysis of three nematode species identifies 93 genes that encode putative components of the ciliated neurons in C. elegans and are subject to the same regulatory control.
Zhao, Zhongying, Thomas, James H., Chen, Nansheng, Sheps, Jonathan A., Baillie, David L.
ABC transporters constitute one of the largest gene families in all species. They are mostly involved in transport of substrates across membranes. We have previously demonstrated that the...
High-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans
Hunt-Newbury, Rebecca, Viveiros, Ryan, Johnsen, Robert, Mah, Allan, Anastas, Dina, Fang, Lily, ...
Using DNA sequences 5′ to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in...
Anyanful, Akwasi, Ono, Kanako, Johnsen, Robert C., Ly, Hinh, Jensen, Victor, Baillie, David L., ...
Tissue-specific alternative pre-mRNA splicing is essential for increasing diversity of functionally different gene products. In Caenorhabditis elegans, UNC-60A and UNC-60B, nonmuscle and muscle...
Identification and analysis of internal promoters in Caenorhabditis elegans operons
Huang, Peiming, Pleasance, Erin D., Maydan, Jason S., Hunt-Newbury, Rebecca, O’Neil, Nigel J., Mah, Allan, ...
The current Caenorhabditis elegans genomic annotation has many genes organized in operons. Using directionally stitched promoter∷GFP methodology, we have conducted the largest survey to date on the...
Hong, Leexan, Elbl, Tricia, Ward, James, Franzini-Armstrong, Clara, Rybicka, Krystyna K., Gatewood, Beth K., ...
Tissue functions and mechanical coupling of cells must be integrated throughout development. A striking example of this coupling is the interactions of body wall muscle and hypodermal cells in...
Ono, Shoichiro, Baillie, David L., Benian, Guy M.
The Caenorhabditis elegans unc-60 gene encodes two functionally distinct isoforms of ADF/cofilin that are implicated in myofibril assembly. Here, we show that one of the gene products, UNC-60B, is...
Transcriptome analysis for Caenorhabditis elegans based on novel expressed sequence tags
Shin, Heesun, Hirst, Martin, Bainbridge, Matthew N, Magrini, Vincent, Mardis, Elaine, Moerman, Donald G, ...
Caruso, Marie-Elaine, Jenna, Sarah, Bouchecareilh, Marion, Baillie, David L., Boismenu, Daniel, Halawani, Dalia, ...
When endoplasmic reticulum (ER) homeostasis is perturbed, an adaptive mechanism is triggered and named the unfolded protein response (UPR). Thus far, three known UPR signaling branches (IRE-1, PERK,...