Rines, Daniel R, Gomez-Ferreria, Maria, Zhou, Yingyao, DeJesus, Paul, Grob, Seanna, Batalov, Serge, ...
Abstract Background The mitotic spindle is a complex mechanical apparatus required for accurate segregation of sister chromosomes during mitosis. We designed a genetic screen using automated...
Lexical retrieval constrained by sound structure: The role of the left inferior frontal gyrus (2005)
Sharp, David J., Scott, Sophie K., Cutler, Anne, Wise, Richard J.S.
Chromokinesins: Possible Generators of Cancer-Associated Aneuploidy (1998)
Sharp, David J., Buster, Daniel W.
Aneuploidy occurs with high frequency in breast cancer cells, and an aneuploidy increase is positively correlated with the transition from pre-malignant to metastatic cancer. Chromokinesins, a family...
Supervised by Donald R. Lessard.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, 1987.
Functional Coordination of Three Mitotic Motors in Drosophila EmbryosV⃞
Sharp, David J., Brown, Heather M., Kwon, Mijung, Rogers, Gregory C., Holland, Gina, Scholey, Jonathan M.
It is well established that multiple microtubule-based motors contribute to the formation and function of the mitotic spindle, but how the activities of these motors interrelate remains unclear. Here...
Kwon, Mijung, Morales-Mulia, Sandra, Brust-Mascher, Ingrid, Rogers, Gregory C., Sharp, David J., Scholey, Jonathan M.
Mitosis requires the concerted activities of multiple microtubule (MT)-based motor proteins. Here we examined the contribution of the chromokinesin, KLP3A, to mitotic spindle morphogenesis and...
Functional Coordination of Three Mitotic Motors in Drosophila EmbryosV⃞
Sharp, David J., Brown, Heather M., Kwon, Mijung, Rogers, Gregory C., Holland, Gina, Scholey, Jonathan M.
It is well established that multiple microtubule-based motors contribute to the formation and function of the mitotic spindle, but how the activities of these motors interrelate remains unclear. Here...
Kwon, Mijung, Morales-Mulia, Sandra, Brust-Mascher, Ingrid, Rogers, Gregory C., Sharp, David J., Scholey, Jonathan M.
Mitosis requires the concerted activities of multiple microtubule (MT)-based motor proteins. Here we examined the contribution of the chromokinesin, KLP3A, to mitotic spindle morphogenesis and...
Poleward Tubulin Flux in Spindles: Regulation and Function in Mitotic Cells
Buster, Daniel W., Zhang, Dong, Sharp, David J.
The poleward flux of tubulin subunits through spindle microtubules is a striking and conserved phenomenon whose function and molecular components remain poorly understood. To screen for novel...
Three microtubule severing enzymes contribute to the “Pacman-flux” machinery that moves chromosomes
Zhang, Dong, Rogers, Gregory C., Buster, Daniel W., Sharp, David J.
Chromosomes move toward mitotic spindle poles by a Pacman-flux mechanism linked to microtubule depolymerization: chromosomes actively depolymerize attached microtubule plus ends (Pacman) while being...
Kinesin-13s form rings around microtubules
Tan, Dongyan, Asenjo, Ana B., Mennella, Vito, Sharp, David J., Sosa, Hernando
Kinesin is a superfamily of motor proteins that uses the energy of adenosine triphosphate hydrolysis to move and generate force along microtubules. A notable exception to this general description is...
A role for IκB kinase 2 in bipolar spindle assembly
Irelan, Jeffrey T., Murphy, Thomas J., DeJesus, Paul D., Teo, Hsiangling, Xu, DingYue, Gomez-Ferreria, Maria A., ...
IκB kinase 2 (IKK2 or IKKβ) is a component of the IKK complex that coordinates the cellular response to a diverse set of extracellular stimuli, including cytokines, microbial infection, and stress....
Sharp, David J, Travlos, Nickolaos G
This article examines the effect of tax factors on the equity values of U.S. multinational corporations making foreign acquisitions. Abnormal stock returns are found to be related to a tax variable...
David J Sharp, Stephen B Salter
Previous North American research suggests that aspects of agency theory and prospect theory may explain decisions to escalate commitment to failing projects. This study explores the universality of...
Yu, Wenqian, Sharp, David J., Kuriyama, Ryoko, Mallik, Prabhat, Baas, Peter W.
Microtubules in the axon are uniformly oriented, while microtubules in the dendrite are nonuniformly oriented. We have proposed that these distinct microtubule polarity patterns may arise from a...
Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation
Sharp, David J., Yu, Wenqian, Ferhat, Lotfi, Kuriyama, Ryoko, Rueger, David C., Baas, Peter W.
The quintessential feature of the dendritic microtubule array is its nonuniform pattern of polarity orientation. During the development of the dendrite, a population of plus end–distal microtubules...
Sharp, David J., McDonald, Kent L., Brown, Heather M., Matthies, Heinrich J., Walczak, Claire, Vale, Ron D., ...
Previous genetic and biochemical studies have led to the hypothesis that the essential mitotic bipolar kinesin, KLP61F, cross-links and slides microtubules (MTs) during spindle assembly and function....
Mitosis, microtubules, and the matrix
Scholey, Jonathan M., Rogers, Gregory C., Sharp, David J.
The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question.
Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle
Rogers, Stephen L., Rogers, Gregory C., Sharp, David J., Vale, Ronald D.
EB1 is an evolutionarily conserved protein that localizes to the plus ends of growing microtubules. In yeast, the EB1 homologue (BIM1) has been shown to modulate microtubule dynamics and link...
Rogers, Gregory C., Chui, Kitty K., Lee, Edwin W., Wedaman, Karen P., Sharp, David J., Holland, Gina, ...
We have investigated the intracellular roles of an Xklp2-related kinesin motor, KRP180, in positioning spindle poles during early sea urchin embryonic cell division using quantitative, real-time...
Rines, Daniel R, Gomez-Ferreria, Maria Ana, Zhou, Yingyao, DeJesus, Paul, Grob, Seanna, Batalov, Serge, ...
A loss-of-function screen for siRNAs that arrest human cells in metaphase reveals genes involved in mitotic spindle integrity.