David G. Huntsman

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer (2008)

FitzGerald, Liesel M, Agalliu, Ilir, Johnson, Karynn, Miller, Melinda A, Kwon, Erika M, Hurtado-Coll, Antonio, ...

Abstract Background The presence of the TMPRSS2-ERG fusion gene in prostate tumors has recently been associated with an aggressive phenotype, as well as recurrence and death from prostate cancer....

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities (2008)

Press, Joshua Z., De Luca, Alessandro, Boyd, Niki, Young, Sean, Troussard, Armelle, Ridge, Yolanda, ...

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities (2008)

Press, Joshua Z, De Luca, Alessandro, Boyd, Niki, Young, Sean, Troussard, Armelle, Ridge, Yolanda, ...

Background Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as...

Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study (2008)

Crabb, Simon J, Bajdik, Chris D, Leung, Samuel, Speers, Caroline H, Kennecke, Hagen, Huntsman, David G, ...

Abstract Introduction Primary breast cancer involving four or more axillary lymph nodes carries a poor prognosis. We hypothesized that use of an immunohistochemical biomarker scoring system could...

Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma (2007)

Prentice, Leah M, Klausen, Christian, Kalloger, Steve, Köbel, Martin, McKinney, Steven, Santos, Jennifer L, ...

Abstract Background Kisspeptins and their G-protein coupled receptor, GPR54 are required for GnRH release and have been associated with anti-metastatic tumour cell behaviour in model systems. The...

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer (2007)

Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R, Huntsman, David G, Cheang, Maggie CU, Akslen, Lars A, ...

Abstract Background Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the...

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer (2007)

Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R., Huntsman, David G., Cheang, Maggie C. U., Akslen, Lars A., ...

Background: Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of...

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer

Tischkowitz, Marc, Brunet, Jean-Sébastien, Bégin, Louis R, Huntsman, David G, Cheang, Maggie CU, Akslen, Lars A, ...

CDH1 Truncating Mutations in the E-Cadherin Gene: An Indication for Total Gastrectomy to Treat Hereditary Diffuse Gastric Cancer

Norton, Jeffrey A., Ham, Christine M., Dam, Jacques Van, Jeffrey, R Brooke, Longacre, Teri A., Huntsman, David G., ...

Germline mutations in the E-cadherin gene (CDH1) have been identified in families with an autosomal dominant inherited predisposition to hereditary diffuse gastric cancer (HDGC). Six individuals from...

Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ1B adaptin

Ling, Kun, Bairstow, Shawn F., Carbonara, Chateen, Turbin, Dmitry A., Huntsman, David G., Anderson, Richard A.

Assembly of E-cadherin–based adherens junctions (AJ) is obligatory for establishment of polarized epithelia and plays a key role in repressing the invasiveness of many carcinomas. Here we show that...

Elevated Expression of DecR1 Impairs ErbB2/Neu-Induced Mammary Tumor Development▿ †

Ursini-Siegel, Josie, Rajput, Ashish B., Lu, Huiling, Sanguin-Gendreau, Virginie, Zuo, Dongmei, Papavasiliou, Vasilios, ...

Tumor cells utilize glucose as a primary energy source and require ongoing lipid biosynthesis for growth. Expression of DecR1, an auxiliary enzyme in the fatty acid β-oxidation pathway, is...

Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases

Rajput, Ashish B., Turbin, Dmitry A., Cheang, Maggie CU, Voduc, David K., Leung, Sam, Gelmon, Karen A., ...

Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma

Prentice, Leah M, Klausen, Christian, Kalloger, Steve, Köbel, Martin, McKinney, Steven, Santos, Jennifer L, ...

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

Press, Joshua Z, De Luca, Alessandro, Boyd, Niki, Young, Sean, Troussard, Armelle, Ridge, Yolanda, ...

Hereditary diffuse gastric cancer: association with lobular breast cancer

Schrader, Kasmintan A., Masciari, Serena, Boyd, Niki, Wiyrick, Sara, Kaurah, Pardeep, Senz, Janine, ...

Hereditary diffuse gastric cancer (HDGC) has been shown to be caused by germline mutations in the gene CDH1 located at 16q22.1, which encodes the cell–cell adhesion molecule, E-cadherin. Not only...

Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study

Crabb, Simon J, Bajdik, Chris D, Leung, Samuel, Speers, Caroline H, Kennecke, Hagen, Huntsman, David G, ...

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer

FitzGerald, Liesel M, Agalliu, Ilir, Johnson, Karynn, Miller, Melinda A, Kwon, Erika M, Hurtado-Coll, Antonio, ...

Expression of Class I Histone Deacetylases Indicates Poor Prognosis in Endometrioid Subtypes of Ovarian and Endometrial Carcinomas1

Weichert, Wilko, Denkert, Carsten, Noske, Aurelia, Darb-Esfahani, Silvia, Dietel, Manfred, Kalloger, Steve E, ...

Histone deacetylase (HDAC) inhibitors are an emerging class of targeted cancer therapeutics, and little is known about HDAC expression in gynecologic malignancies. Therefore, we tested the hypothesis...