David G. Brooks

Mitochondria-derived Reactive Oxygen Species Mediate Blue Light–induced Death of Retinal Pigment Epithelial Cells¶ (2004)

Ayala King, Eyal Gottlieb, David G. Brooks, Michael P. Murphy, Joshua L. Dunaief

Throughout the lifetime of an individual, light is focused onto the retina. The resulting photooxidative stress can cause acute or chronic retinal damage. The pathogenesis of age-related macular...

Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (2004)

Ali, Ayub, Lubong, Rachel, Ng, Hwee, Brooks, David G, Zack, Jerome A, Yang, Otto O

The determinants of CD8(+) cytotoxic T-lymphocyte (CTL) antiviral activity against human immunodeficiency virus type 1 (HIV-1) remain poorly defined. Although recent technological advances have...

Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. (1999)

Annunen, Susanna, K Rkk , Jarmo, Czarny, Malwina, Warman, Matthew L., Brunner, Han G., K Ri Inen, Helena, ...

Stickler and Marshall syndromes are dominantly inherited chondrodysplasias characterized by midfacial hypoplasia, high myopia, and sensorineural-hearing deficit. Since the characteristics of these...

Icons and edges :--metaphors on the spatial plane /--by David G. Brooks. (1980)

Brooks, David G.

Creative project in lieu of thesis (M.F.A.)--University of Florida, 1980.

Human Immunodeficiency Virus Type 1-Induced Hematopoietic Inhibition Is Independent of Productive Infection of Progenitor Cells In Vivo

Koka, Prasad S., Jamieson, Beth D., Brooks, David G., Zack, Jerome A.

Human immunodeficiency virus (HIV)-infected individuals exhibit a variety of hematopoietic dysfunctions. The SCID-hu mouse (severe combined immunodeficient mouse transplanted with human fetal thymus...

Effect of Latent Human Immunodeficiency Virus Infection on Cell Surface Phenotype

Brooks, David G., Zack, Jerome A.

Highly active antiretroviral therapy has succeeded in many cases in suppressing virus production in patients infected with human immunodeficiency virus (HIV); however, once treatment is discontinued,...

Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype

Scripture-Adams, Deirdre D., Brooks, David G., Korin, Yael D., Zack, Jerome A.

Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral...

Identification of T cell-signaling pathways that stimulate latent HIV in primary cells

Brooks, David G., Arlen, Philip A., Gao, Lianying, Kitchen, Christina M. R., Zack, Jerome A.

Eradication of HIV infection depends on the elimination of a small, but stable population of latently infected T cells. After the discontinuation of therapy, activation of latent virus can rekindle...

Impacts of Epitope Expression Kinetics and Class I Downregulation on the Antiviral Activity of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes

Ali, Ayub, Lubong, Rachel, Ng, Hwee, Brooks, David G., Zack, Jerome A., Yang, Otto O.

The determinants of CD8+ cytotoxic T-lymphocyte (CTL) antiviral activity against human immunodeficiency virus type 1 (HIV-1) remain poorly defined. Although recent technological advances have...

CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection

Kitchen, Scott G., Jones, Nicole R., LaForge, Stuart, Whitmire, Jason K., Vu, Bien-Aimee, Galic, Zoran, ...

Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4...

Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection

Brooks, David G., Teyton, Luc, Oldstone, Michael B. A., McGavern, Dorian B.

Effective T-cell responses are critical to eradicate acute viral infections and prevent viral persistence. Emerging evidence indicates that robust, early CD4 T-cell responses are important in...

Splicing Mutations of 54-bp Exons in the COL11A1 Gene Cause Marshall Syndrome, but Other Mutations Cause Overlapping Marshall/Stickler Phenotypes

Annunen, Susanna, Körkkö, Jarmo, Czarny, Malwina, Warman, Matthew L., Brunner, Han G., Kääriäinen, Helena, ...

Stickler and Marshall syndromes are dominantly inherited chondrodysplasias characterized by midfacial hypoplasia, high myopia, and sensorineural-hearing deficit. Since the characteristics of these...

Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency

Korin, Yael D., Brooks, David G., Brown, Stephen, Korotzer, Andrew, Zack, Jerome A.

Human immunodeficiency virus (HIV) replication is linked to cellular gene transcription and requires target cell activation. The latent reservoir of HIV-1 in quiescent T cells is thought to be a...

Rapid Expression of Human Immunodeficiency Virus following Activation of Latently Infected Cells

Arlen, Philip A., Brooks, David G., Gao, Lian Y., Vatakis, Dimitrios, Brown, Helen J., Zack, Jerome A.

The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent...

Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection

Brooks, David G., McGavern, Dorian B., Oldstone, Michael B.A.

Failure to clear persistent viral infections results from the early loss of T cell activity. A pertinent question is whether the immune response is programmed to fail or if nonresponsive T cells can...

Human Immunodeficiency Virus Type 1-Induced Hematopoietic Inhibition Is Independent of Productive Infection of Progenitor Cells In Vivo

Koka, Prasad S., Jamieson, Beth D., Brooks, David G., Zack, Jerome A.

Human immunodeficiency virus (HIV)-infected individuals exhibit a variety of hematopoietic dysfunctions. The SCID-hu mouse (severe combined immunodeficient mouse transplanted with human fetal thymus...

Effect of Latent Human Immunodeficiency Virus Infection on Cell Surface Phenotype

Brooks, David G., Zack, Jerome A.

Highly active antiretroviral therapy has succeeded in many cases in suppressing virus production in patients infected with human immunodeficiency virus (HIV); however, once treatment is discontinued,...

Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype

Scripture-Adams, Deirdre D., Brooks, David G., Korin, Yael D., Zack, Jerome A.

Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral...

Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency

Korin, Yael D., Brooks, David G., Brown, Stephen, Korotzer, Andrew, Zack, Jerome A.

Human immunodeficiency virus (HIV) replication is linked to cellular gene transcription and requires target cell activation. The latent reservoir of HIV-1 in quiescent T cells is thought to be a...

Identification of T cell-signaling pathways that stimulate latent HIV in primary cells

Brooks, David G., Arlen, Philip A., Gao, Lianying, Kitchen, Christina M. R., Zack, Jerome A.

Eradication of HIV infection depends on the elimination of a small, but stable population of latently infected T cells. After the discontinuation of therapy, activation of latent virus can rekindle...

Impacts of Epitope Expression Kinetics and Class I Downregulation on the Antiviral Activity of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes

Ali, Ayub, Lubong, Rachel, Ng, Hwee, Brooks, David G., Zack, Jerome A., Yang, Otto O.

The determinants of CD8+ cytotoxic T-lymphocyte (CTL) antiviral activity against human immunodeficiency virus type 1 (HIV-1) remain poorly defined. Although recent technological advances have...

CD4 on CD8+ T cells directly enhances effector function and is a target for HIV infection

Kitchen, Scott G., Jones, Nicole R., LaForge, Stuart, Whitmire, Jason K., Vu, Bien-Aimee, Galic, Zoran, ...

Costimulation of purified CD8+ T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4...

Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection

Brooks, David G., Teyton, Luc, Oldstone, Michael B. A., McGavern, Dorian B.

Effective T-cell responses are critical to eradicate acute viral infections and prevent viral persistence. Emerging evidence indicates that robust, early CD4 T-cell responses are important in...

Splicing Mutations of 54-bp Exons in the COL11A1 Gene Cause Marshall Syndrome, but Other Mutations Cause Overlapping Marshall/Stickler Phenotypes

Annunen, Susanna, Körkkö, Jarmo, Czarny, Malwina, Warman, Matthew L., Brunner, Han G., Kääriäinen, Helena, ...

Stickler and Marshall syndromes are dominantly inherited chondrodysplasias characterized by midfacial hypoplasia, high myopia, and sensorineural-hearing deficit. Since the characteristics of these...

Rapid Expression of Human Immunodeficiency Virus following Activation of Latently Infected Cells

Arlen, Philip A., Brooks, David G., Gao, Lian Y., Vatakis, Dimitrios, Brown, Helen J., Zack, Jerome A.

The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent...

Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection

Brooks, David G., McGavern, Dorian B., Oldstone, Michael B.A.

Failure to clear persistent viral infections results from the early loss of T cell activity. A pertinent question is whether the immune response is programmed to fail or if nonresponsive T cells can...

IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection

Brooks, David G., Lee, Andrew M., Elsaesser, Heidi, McGavern, Dorian B., Oldstone, Michael B.A.

Therapeutic vaccination is a potentially powerful strategy to establish immune control and eradicate persistent viral infections. Large and multifunctional antiviral T cell responses are associated...