Daniel N. Streblow

The Human Cytomegalovirus IE86 Protein Can Block Cell Cycle Progression after Inducing Transition into the S Phase of Permissive Cells

Murphy, Eain A., Streblow, Daniel N., Nelson, Jay A., Stinski, Mark F.

Human cytomegalovirus (HCMV) infection of permissive cells has been reported to induce a cell cycle halt. One or more viral proteins may be involved in halting progression at different stages of the...

Reactivation of Latent Human Cytomegalovirus in CD14+ Monocytes Is Differentiation Dependent

Söderberg-Nauclér, Cecilia, Streblow, Daniel N., Fish, Kenneth N., Allan-Yorke, Justine, Smith, Patricia P., Nelson, Jay A.

We have previously demonstrated reactivation of latent human cytomegalovirus (HCMV) in myeloid lineage cells obtained from healthy donors. Virus was obtained from allogenically stimulated...

Retrieval of Human Cytomegalovirus Glycoprotein B from Cell Surface Is Not Required for Virus Envelopment in Astrocytoma Cells

Jarvis, Michael A., Fish, Kenneth N., Söderberg-Naucler, Cecilia, Streblow, Daniel N., Meyers, Heather L., Thomas, Gary, ...

Human cytomegalovirus (HCMV) is a prototypic member of the betaherpesvirus family. The HCMV virion is composed of a large DNA genome encapsidated within a nucleocapsid, which is wrapped within an...

Cytomegalovirus-Mediated Upregulation of Chemokine Expression Correlates with the Acceleration of Chronic Rejection in Rat Heart Transplants

Streblow, Daniel N., Kreklywich, Craig, Yin, Qiang, De La Melena, V. T., Corless, Christopher L., Smith, Patricia A., ...

Cytomegalovirus (CMV) infections have been shown to dramatically affect solid organ transplant graft survival in both human and animal models. Recently, it was demonstrated that rat CMV (RCMV)...

Human Cytomegalovirus-Encoded G Protein-Coupled Receptor US28 Mediates Smooth Muscle Cell Migration through Gα12

Melnychuk, Ryan M., Streblow, Daniel N., Smith, Patricia P., Hirsch, Alec J., Pancheva, Dora, Nelson, Jay A.

Coupling of G proteins to ligand-engaged chemokine receptors is the paramount event in G-protein-coupled receptor signal transduction. Previously, we have demonstrated that the human...

Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome†

Varnum, Susan M., Streblow, Daniel N., Monroe, Matthew E., Smith, Patricia, Auberry, Kenneth J., Paša-Tolić, Ljiljana, ...

Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products. While the sequence of the HCMV genome has been...

Mouse Cytomegalovirus M33 Is Necessary and Sufficient in Virus-Induced Vascular Smooth Muscle Cell Migration

Melnychuk, Ryan M., Smith, Patsy, Kreklywich, Craig N., Ruchti, Franziska, Vomaske, Jennifer, Hall, Laurel, ...

Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-encoded chemokine receptors...

Integrin α4β1 Promotes Focal Adhesion Kinase-Independent Cell Motility via α4 Cytoplasmic Domain-Specific Activation of c-Src‡

Hsia, Datsun A., Lim, Ssang-Taek, Bernard-Trifilo, Joie A., Mitra, Satyajit K., Tanaka, Sakae, Den Hertog, Jeroen, ...

The fibronectin binding integrins α5β1 and α4β1 generate signals pivotal for cell migration through distinct yet undefined mechanisms. For α5β1, β1-mediated activation of focal adhesion kinase...

Focal Adhesion Kinase Is Critical for Entry of Kaposi's Sarcoma-Associated Herpesvirus into Target Cells

Krishnan, Harinivas H., Sharma-Walia, Neelam, Streblow, Daniel N., Naranatt, Pramod P., Chandran, Bala

Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) interacts with cell surface α3β1 integrin early during in vitro infection of human endothelial cells and fibroblasts and...

The Human Cytomegalovirus IE86 Protein Can Block Cell Cycle Progression after Inducing Transition into the S Phase of Permissive Cells

Murphy, Eain A., Streblow, Daniel N., Nelson, Jay A., Stinski, Mark F.

Human cytomegalovirus (HCMV) infection of permissive cells has been reported to induce a cell cycle halt. One or more viral proteins may be involved in halting progression at different stages of the...

Reactivation of Latent Human Cytomegalovirus in CD14+ Monocytes Is Differentiation Dependent

Söderberg-Nauclér, Cecilia, Streblow, Daniel N., Fish, Kenneth N., Allan-Yorke, Justine, Smith, Patricia P., Nelson, Jay A.

We have previously demonstrated reactivation of latent human cytomegalovirus (HCMV) in myeloid lineage cells obtained from healthy donors. Virus was obtained from allogenically stimulated...

Retrieval of Human Cytomegalovirus Glycoprotein B from Cell Surface Is Not Required for Virus Envelopment in Astrocytoma Cells

Jarvis, Michael A., Fish, Kenneth N., Söderberg-Naucler, Cecilia, Streblow, Daniel N., Meyers, Heather L., Thomas, Gary, ...

Human cytomegalovirus (HCMV) is a prototypic member of the betaherpesvirus family. The HCMV virion is composed of a large DNA genome encapsidated within a nucleocapsid, which is wrapped within an...

Cytomegalovirus-Mediated Upregulation of Chemokine Expression Correlates with the Acceleration of Chronic Rejection in Rat Heart Transplants

Streblow, Daniel N., Kreklywich, Craig, Yin, Qiang, De La Melena, V. T., Corless, Christopher L., Smith, Patricia A., ...

Cytomegalovirus (CMV) infections have been shown to dramatically affect solid organ transplant graft survival in both human and animal models. Recently, it was demonstrated that rat CMV (RCMV)...

Human Cytomegalovirus-Encoded G Protein-Coupled Receptor US28 Mediates Smooth Muscle Cell Migration through Gα12

Melnychuk, Ryan M., Streblow, Daniel N., Smith, Patricia P., Hirsch, Alec J., Pancheva, Dora, Nelson, Jay A.

Coupling of G proteins to ligand-engaged chemokine receptors is the paramount event in G-protein-coupled receptor signal transduction. Previously, we have demonstrated that the human...

Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome†

Varnum, Susan M., Streblow, Daniel N., Monroe, Matthew E., Smith, Patricia, Auberry, Kenneth J., Paša-Tolić, Ljiljana, ...

Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products. While the sequence of the HCMV genome has been...

Mouse Cytomegalovirus M33 Is Necessary and Sufficient in Virus-Induced Vascular Smooth Muscle Cell Migration

Melnychuk, Ryan M., Smith, Patsy, Kreklywich, Craig N., Ruchti, Franziska, Vomaske, Jennifer, Hall, Laurel, ...

Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-encoded chemokine receptors...

Integrin α4β1 Promotes Focal Adhesion Kinase-Independent Cell Motility via α4 Cytoplasmic Domain-Specific Activation of c-Src‡

Hsia, Datsun A., Lim, Ssang-Taek, Bernard-Trifilo, Joie A., Mitra, Satyajit K., Tanaka, Sakae, Den Hertog, Jeroen, ...

The fibronectin binding integrins α5β1 and α4β1 generate signals pivotal for cell migration through distinct yet undefined mechanisms. For α5β1, β1-mediated activation of focal adhesion kinase...

Focal Adhesion Kinase Is Critical for Entry of Kaposi's Sarcoma-Associated Herpesvirus into Target Cells

Krishnan, Harinivas H., Sharma-Walia, Neelam, Streblow, Daniel N., Naranatt, Pramod P., Chandran, Bala

Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) interacts with cell surface α3β1 integrin early during in vitro infection of human endothelial cells and fibroblasts and...

Rat Cytomegalovirus Gene Expression in Cardiac Allograft Recipients Is Tissue Specific and Does Not Parallel the Profiles Detected In Vitro▿

Streblow, Daniel N., Kreklywich, Craig N., Meyer, Christine, Smith, Patricia, Defilippis, Victor, ...

Rat cytomegalovirus (RCMV) is a β-herpesvirus with a 230-kbp genome containing over 167 open reading frames (ORFs). RCMV gene expression is tightly regulated in cultured cells, occurring in three...

HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells

Heinzel, Amy S., Grotzke, Jeff E., Lines, Rebecca A., Lewinsohn, Deborah A., McNabb, Andria L., Streblow, Daniel N., ...

Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or...

Differential regulation of cell motility and invasion by FAK

Hsia, Datsun A., Mitra, Satyajit K., Hauck, Christof R., Streblow, Daniel N., Nelson, Jay A., Ilic, Dusko, ...

Cell migration and invasion are fundamental components of tumor cell metastasis. Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are connected with elevated...

Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes▿

Prichard, Mark N., Sztul, Elizabeth, Daily, Shannon L., Perry, Amie L., Frederick, Samuel L., Gill, Rachel B., ...

Cells infected with human cytomegalovirus in the absence of UL97 kinase activity produce large nuclear aggregates that sequester considerable quantities of viral proteins. A transient expression...

West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of αvβ3 Integrin▿ †

Medigeshi, Guruprasad R., Hirsch, Alec J., Streblow, Daniel N., Nikolich-Zugich, Janko, Nelson, Jay A.

West Nile virus (WNV) has been the leading cause of viral encephalitis in the United States since 1999. The endocytic processes involved in the internalization of infectious WNV by various cell types...

Human Cytomegalovirus Secretome Contains Factors That Induce Angiogenesis and Wound Healing▿

Dumortier, Jerome, Streblow, Daniel N., Moses, Ashlee V., Jacobs, Jon M., Kreklywich, Craig N., Camp, David, ...

Human cytomegalovirus (HCMV) is implicated in the acceleration of a number of vascular diseases including transplant vascular sclerosis (TVS), the lesion associated with chronic rejection (CR) of...