Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...
BACKGROUND: Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...
Background Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Jeffrey C. Lee, Igor Vivanco, Rameen Beroukhim, Whei L. Feng, Ralph M. DeBiasi, ...
BackgroundProtein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
EGFR activation in glioblastoma through novel missense mutations in the extracellular domain (2006)
Lee, Jeffrey C., Huang, Julie H.Y., Beroukhim, Rameen, Feng, Whei L., DeBiasi, R.M., King, J.C., ...
Sequence of 12 Monoclonal Anti-Dinitrophenyl Spin-Label Antibodies for NMR Studies, (1998)
Leahy, Daniel J., Rule, Gordon R., Whittaker, Mei M., McConnell, Harden M.
Eleven monoclonal antibodies specific for a spin-labeled dinitrophenyl hapten (DNP-SL) have been produced for use in NMR studies. They have been named AN01 and AN03-AN12. The stability constants for...
Leahy, Daniel J., Hynes, Thomas, Fox, Robert O., McConnell, Harden M.
The structural change that an antibody undergoes upon binding of antigen is interesting in terms of antibody diversity and function. Independent crystal structures of an antibody both with and...
Structure and Machanism-Base Design of ErbB Receptor Inhibitors (1998)
The work proposed for this award involved using the crystal structures of the extracellular domains of the EGF receptor (EGFR) and its homologs HER2/Neu/ErbB2, HER3/ErbB3, and HER4/ErbB4, which were...
Física programada / Alexander Joseph, Daniel J. Leahy (1970)
Joseph, Alexander, Leahy, Daniel J
Traducción de: programmed physics
Programmed physics / Alexander Joseph and Daniel J. Leahy (1965)
Joseph, Alexander, Leahy, Daniel J
Part I: Mechanics -- Part II: Electricity and Magnetism -- Part III: Optics and Waves
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
Fuse, Naoyuki, Maiti, Tapan, Wang, Baolin, Porter, Jeffery A., Hall, Traci M. Tanaka, Leahy, Daniel J., ...
The amino-terminal signaling domain of the Sonic hedgehog secreted protein (Shh-N), which derives from the Shh precursor through an autoprocessing reaction mediated by the carboxyl-terminal domain,...
Hamaoka, Brent Y., Dann, Charles E., Geisbrecht, Brian V., Leahy, Daniel J.
HER-1 is a secreted protein that promotes male development in the nematode Caenorhabditis elegans. HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to serve as its...
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Bouyain, Samuel, Longo, Patti A., Li, Shiqing, Ferguson, Kathryn M., Leahy, Daniel J.
The human ErbB family of receptor tyrosine kinases comprises the epidermal growth factor receptor (EGFR/ErbB1/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). ErbBs play fundamental roles in...
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
Fuse, Naoyuki, Maiti, Tapan, Wang, Baolin, Porter, Jeffery A., Hall, Traci M. Tanaka, Leahy, Daniel J., ...
The amino-terminal signaling domain of the Sonic hedgehog secreted protein (Shh-N), which derives from the Shh precursor through an autoprocessing reaction mediated by the carboxyl-terminal domain,...
Hamaoka, Brent Y., Dann, Charles E., Geisbrecht, Brian V., Leahy, Daniel J.
HER-1 is a secreted protein that promotes male development in the nematode Caenorhabditis elegans. HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to serve as its...
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
Bouyain, Samuel, Longo, Patti A., Li, Shiqing, Ferguson, Kathryn M., Leahy, Daniel J.
The human ErbB family of receptor tyrosine kinases comprises the epidermal growth factor receptor (EGFR/ErbB1/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). ErbBs play fundamental roles in...
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H. Y, Feng, Whei L, DeBiasi, Ralph M, ...
Ingo Mellinghoff and colleagues sequenced theEGFR gene in glioblastoma samples and cell lines and identified missense mutations in the extracellular domain that suggest a new mechanism for EGFR...
Structure of a heparin-dependent complex of Hedgehog and Ihog
McLellan, Jason S., Yao, Shenqin, Zheng, Xiaoyan, Geisbrecht, Brian V., Ghirlando, Rodolfo, Beachy, Philip A., ...
Hedgehog (Hh) signaling molecules mediate key tissue-patterning events during animal development, and inappropriate activation of Hh signaling in adults has been associated with human cancers....
Structural basis for ligand and heparin binding to neuropilin B domains
Vander Kooi, Craig W., Jusino, Manuel A., Perman, Benjamin, Neau, David B., Bellamy, Henry D., Leahy, Daniel J.
Neuropilin (Nrp) is a cell surface receptor with essential roles in angiogenesis and axon guidance. Interactions between Nrp and the positively charged C termini of its ligands, VEGF and semaphorin,...
Bouyain, Samuel, Leahy, Daniel J.
The E3 ubiquitin ligase neuregulin receptor degrading protein 1 (Nrdp1) mediates the ligand-independent degradation of the epidermal growth factor receptor family member ErbB3/HER3. By regulating...
Structure and stability of the ankyrin domain of the Drosophila Notch receptor
Zweifel, Mark E., Leahy, Daniel J., Hughson, Frederick M., Barrick, Doug
The Notch receptor contains a conserved ankyrin repeat domain that is required for Notch-mediated signal transduction. The ankyrin domain of Drosophila Notch contains six ankyrin sequence repeats...
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Suh, Yousin, Atzmon, Gil, Cho, Mi-Ook, Hwang, David, Liu, Bingrong, Leahy, Daniel J., ...
Rather than being a passive, haphazard process of wear and tear, lifespan can be modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in laboratory animals....