Daniel De Backer

How to evaluate the microcirculation: report of a round table conference (2007)

De Backer, Daniel, Hollenberg, Steven, Boerma, Christiaan, Goedhart, Peter, Büchele, Gustavo, Ospina-Tascon, Gustavo, ...

Abstract Introduction Microvascular alterations may play an important role in the development of organ failure in critically ill patients and especially in sepsis. Recent advances in technology have...

Can passive leg raising be used to guide fluid administration? (2006)

De Backer, Daniel

Abstract Predicting fluid responsiveness has become a topic of major interest. Measurements of intravascular pressures and volumes often fail to predict the response to fluids, even though very low...

How can the response to volume expansion in patients with spontaneous respiratory movements be predicted? (2006)

Heenen, Sarah, De Backer, Daniel, Vincent, Jean-Louis

Abstract Introduction The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory...

Optimal management of the high risk surgical patient: beta stimulation or beta blockade? (2005)

De Backer, Daniel

Abstract Several groups of investigators have shown that peri-operative goal directed therapy (GDT) may reduce mortality in high-risk surgical patients. GDT usually requires the use of...

Microvascular dysfunction as a cause of organ dysfunction in severe sepsis (2005)

Vincent, Jean-Louis, De Backer, Daniel

Abstract Reduced microvascular perfusion has been implicated in organ dysfunction and multiple organ failure associated with severe sepsis. The precise mechanisms underlying microvascular dysfunction...

The cuff-leak test: what are we measuring? (2004)

De Backer, Daniel

Abstract Stridor is one of the most frequent causes of early extubation failure. The cuff-leak test may help to identify patients at risk to develop post-extubation laryngeal edema. However the...

Clinical review: Influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock (2003)

Asfar, Pierre, De Backer, Daniel, Meier-Hellmann, Andreas, Radermacher, Peter, Sakka, Samir G

Abstract The organs of the hepatosplanchnic system are considered to play a key role in the development of multiorgan failure during septic shock. Impaired oxygenation of the intestinal mucosa can...

Perioperative optimization and right heart catheterization: what technique in which patient? (2003)

De Backer, Daniel, Creteur, Jacques, Vincent, Jean-Louis

Abstract Recent years have seen the place of the pulmonary artery catheter in intensive care increasingly challenged, with one recent study reporting no difference in outcome in patients treated with...

The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is dopamine rather than norepinephrine (2002)

Vincent, Jean-Louis, De Backer, Daniel

Abstract Norepinephrine (noradrenaline) and dopamine are commonly used first-line vasopressor agents in the treatment of patients with septic shock. Recently increasing interest has focused on...

The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is dopamine rather than norepinephrine

Vincent, Jean-Louis, De Backer, Daniel

Norepinephrine (noradrenaline) and dopamine are commonly used first-line vasopressor agents in the treatment of patients with septic shock. Recently increasing interest has focused on whether one or...

Perioperative optimization and right heart catheterization: what technique in which patient?

De Backer, Daniel, Creteur, Jacques, Vincent, Jean-Louis

Recent years have seen the place of the pulmonary artery catheter in intensive care increasingly challenged, with one recent study reporting no difference in outcome in patients treated with or...

Clinical review: Influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock

Asfar, Pierre, De Backer, Daniel, Meier-Hellmann, Andreas, Radermacher, Peter, Sakka, Samir G

The organs of the hepatosplanchnic system are considered to play a key role in the development of multiorgan failure during septic shock. Impaired oxygenation of the intestinal mucosa can lead to...

The cuff-leak test: what are we measuring?

De Backer, Daniel

Stridor is one of the most frequent causes of early extubation failure. The cuff-leak test may help to identify patients at risk to develop post-extubation laryngeal edema. However the discrimination...

Optimal management of the high risk surgical patient: beta stimulation or beta blockade?

De Backer, Daniel

Several groups of investigators have shown that peri-operative goal directed therapy (GDT) may reduce mortality in high-risk surgical patients. GDT usually requires the use of beta-adrenergic agents,...

The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is dopamine rather than norepinephrine

Vincent, Jean-Louis, De Backer, Daniel

Norepinephrine (noradrenaline) and dopamine are commonly used first-line vasopressor agents in the treatment of patients with septic shock. Recently increasing interest has focused on whether one or...

Perioperative optimization and right heart catheterization: what technique in which patient?

De Backer, Daniel, Creteur, Jacques, Vincent, Jean-Louis

Recent years have seen the place of the pulmonary artery catheter in intensive care increasingly challenged, with one recent study reporting no difference in outcome in patients treated with or...

Clinical review: Influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock

Asfar, Pierre, De Backer, Daniel, Meier-Hellmann, Andreas, Radermacher, Peter, Sakka, Samir G

The organs of the hepatosplanchnic system are considered to play a key role in the development of multiorgan failure during septic shock. Impaired oxygenation of the intestinal mucosa can lead to...

The cuff-leak test: what are we measuring?

De Backer, Daniel

Stridor is one of the most frequent causes of early extubation failure. The cuff-leak test may help to identify patients at risk to develop post-extubation laryngeal edema. However the discrimination...

Optimal management of the high risk surgical patient: beta stimulation or beta blockade?

De Backer, Daniel

Several groups of investigators have shown that peri-operative goal directed therapy (GDT) may reduce mortality in high-risk surgical patients. GDT usually requires the use of beta-adrenergic agents,...

Can passive leg raising be used to guide fluid administration?

De Backer, Daniel

Predicting fluid responsiveness has become a topic of major interest. Measurements of intravascular pressures and volumes often fail to predict the response to fluids, even though very low values are...

Prediction of Postoperative Complications After Urgent Laparotomy by Intraperitoneal Microdialysis: A Pilot Study

Verdant, Colin L., Chierego, Marialuisa, De Moor, Véronique, Chamlou, Reza, Creteur, Jacques, De Dieu Mutijima, Jean, ...

Intraperitoneal microdialysis (IPM) revealed higher lactate/pyruvate ratios in patients who had a complicated course. Our findings suggest that IPM techniques can represent a safe and reliable means...