D. Martin Watterson

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury (2008)

Lloyd, Eric, Somera-Molina, Kathleen, Van Eldik, Linda J, Watterson, D Martin, Wainwright, Mark S

Abstract Background Traumatic brain injury (TBI) with its associated morbidity is a major area of unmet medical need that lacks effective therapies. TBI initiates a neuroinflammatory cascade...

A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model (2007)

Munoz, Lenka, Ranaivo, Hantamalala, Roy, Saktimayee M, Hu, Wenhui, Craft, Jeffrey M, McNamara, Laurie K, ...

Abstract Background An accumulating body of evidence is consistent with the hypothesis that excessive or prolonged increases in proinflammatory cytokine production by activated glia is a contributor...

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid (2005)

Craft, Jeffrey M, Watterson, D Martin, Hirsch, Emmet, Van Eldik, Linda J

Abstract Background Interleukin 1 (IL-1) is a key mediator of immune responses in health and disease. Although classically the function of IL-1 has been studied in the systemic immune system,...

Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

Wainwright, Mark S., Rossi, Janet, Schavocky, James, Crawford, Susan, Steinhorn, David, Velentza, Anastasia V., ...

Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule...

Isolation and characterization of calmodulin from spinach leaves and in vitro translation mixtures

Eldik, Linda J. Van, Grossman, Arthur R., Iverson, David B., Watterson, D. Martin

Calmodulin, a multifunctional calcium-modulated protein, has been isolated from spinach leaf tissue and from spinach leaf messenger RNA translation products. The translation protein and the spinach...

Amino Acid Sequence of a Novel Calmodulin from the Unicellular Alga Chlamydomonas1

Lukas, Thomas J., Wiggins, Michael E., Watterson, D. Martin

An amino acid sequence for a Chlamydomonas calmodulin has been elucidated with emphasis on the characterization of differences that are unique to Chlamydomonas and Dictyostelium calmodulin. While the...

Further Characterization of Calmodulin from the Monocotyledon Barley (Hordeum vulgare) 1

Schleicher, Michael, Lukas, Thomas J., Watterson, D. Martin

We report here that calmodulin isolated from the monocotyledon barley is indistinguishable by a variety of criteria from calmodulin isolated from the dicotyledon spinach. In contrast to previous...

Structural Characterization of a Higher Plant Calmodulin 1: Spinacia Oleracea

Lukas, Thomas J., Iverson, David B., Schleicher, Michael, Watterson, D. Martin

Calmodulin is a eukaryotic calcium binding protein which has several calcium-dependent in vitro activities. Presented in this report is a structural characterization of calmodulin from spinach leaves...

Comparison of the NAD Kinase and Myosin Light Chain Kinase Activator Properties of Vertebrate, Higher Plant, and Algal Calmodulins 1

Roberts, Daniel M., Burgess, Wilson H., Watterson, D. Martin

In the preceding paper (Lukas, Iverson, Schleicher, Watterson 1984 Plant Physiol 75: 788-795), we reported that the amino acid sequence of spinach calmodulin has at least 13 amino acid sequence...

Epithelial myosin light chain kinase–dependent barrier dysfunction mediates T cell activation–induced diarrhea in vivo

Clayburgh, Daniel R., Barrett, Terrence A., Tang, Yueming, Meddings, Jon B., Van Eldik, Linda J., Watterson, D. Martin, ...

Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined....

Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment

Wainwright, Mark S., Rossi, Janet, Schavocky, James, Crawford, Susan, Steinhorn, David, Velentza, Anastasia V., ...

Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule...

Isolation and characterization of calmodulin from spinach leaves and in vitro translation mixtures

Eldik, Linda J. Van, Grossman, Arthur R., Iverson, David B., Watterson, D. Martin

Calmodulin, a multifunctional calcium-modulated protein, has been isolated from spinach leaf tissue and from spinach leaf messenger RNA translation products. The translation protein and the spinach...

Amino Acid Sequence of a Novel Calmodulin from the Unicellular Alga Chlamydomonas1

Lukas, Thomas J., Wiggins, Michael E., Watterson, D. Martin

An amino acid sequence for a Chlamydomonas calmodulin has been elucidated with emphasis on the characterization of differences that are unique to Chlamydomonas and Dictyostelium calmodulin. While the...

Further Characterization of Calmodulin from the Monocotyledon Barley (Hordeum vulgare) 1

Schleicher, Michael, Lukas, Thomas J., Watterson, D. Martin

We report here that calmodulin isolated from the monocotyledon barley is indistinguishable by a variety of criteria from calmodulin isolated from the dicotyledon spinach. In contrast to previous...

Structural Characterization of a Higher Plant Calmodulin 1: Spinacia Oleracea

Lukas, Thomas J., Iverson, David B., Schleicher, Michael, Watterson, D. Martin

Calmodulin is a eukaryotic calcium binding protein which has several calcium-dependent in vitro activities. Presented in this report is a structural characterization of calmodulin from spinach leaves...

Comparison of the NAD Kinase and Myosin Light Chain Kinase Activator Properties of Vertebrate, Higher Plant, and Algal Calmodulins 1

Roberts, Daniel M., Burgess, Wilson H., Watterson, D. Martin

In the preceding paper (Lukas, Iverson, Schleicher, Watterson 1984 Plant Physiol 75: 788-795), we reported that the amino acid sequence of spinach calmodulin has at least 13 amino acid sequence...

Epithelial myosin light chain kinase–dependent barrier dysfunction mediates T cell activation–induced diarrhea in vivo

Clayburgh, Daniel R., Barrett, Terrence A., Tang, Yueming, Meddings, Jon B., Van Eldik, Linda J., Watterson, D. Martin, ...

Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined....

Protection Against Endotoxic Shock as a Consequence of Reduced Nitrosative Stress in MLCK210-Null Mice

Ranaivo, Hantamalala Ralay, Carusio, Nunzia, Wangensteen, Rosemary, Ohlmann, Patrick, Loichot, Cecile, Tesse, Angela, ...

This study investigated the consequences of deletion of the long isoform of myosin light chain kinase (MLCK210) on the cardiovascular changes induced by the bacterial endotoxin lipopolysaccharide...