Cynthia R. Shirley

Abnormalities and Reduced Reproductive Potential of Sperm from Tnp1- and Tnp2-Null Double Mutant Mice1 (2004)

Cynthia R. Shirley, Shotaro Hayashi, Suzanne Mounsey, Ryuzo Yanagimachi, Marvin L. Meistrich

Previous studies have demonstrated the importance of transition nuclear proteins, TP1 and TP2, in spermatogenesis and male fertility. However, importance of the overall level of transition proteins...

Nucleoprotein Transitions During Spermiogenesis in Mice with Transition Nuclear Protein Tnp1 and Tnp2 Mutations1 (2004)

Ming Zhao, Cynthia R. Shirley, Suzanne Mounsey, Marvin L. Meistrich

Chromatin remodeling during spermiogenesis is characterized by a series of nuclear protein replacements. Histones are replaced by transition nuclear proteins, which are in turn replaced by...

Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice

Yu, Y. Eugene, Zhang, Yun, Unni, Emmanual, Shirley, Cynthia R., Deng, Jian M., Russell, Lonnie D., ...

Transition nuclear proteins (TPs), the major proteins found in chromatin of condensing spermatids, are believed to be important for histone displacement and chromatin condensation during mammalian...

Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in Mice†

Zhao, Ming, Shirley, Cynthia R., Yu, Y. Eugene, Mohapatra, Bhagyalaxmi, Zhang, Yun, Unni, Emmanual, ...

During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the...

Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice

Yu, Y. Eugene, Zhang, Yun, Unni, Emmanual, Shirley, Cynthia R., Deng, Jian M., Russell, Lonnie D., ...

Transition nuclear proteins (TPs), the major proteins found in chromatin of condensing spermatids, are believed to be important for histone displacement and chromatin condensation during mammalian...

Targeted Disruption of the Transition Protein 2 Gene Affects Sperm Chromatin Structure and Reduces Fertility in Mice†

Zhao, Ming, Shirley, Cynthia R., Yu, Y. Eugene, Mohapatra, Bhagyalaxmi, Zhang, Yun, Unni, Emmanual, ...

During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the...

Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa

Perl, Andras, Qian, Yueming, Chohan, Kazim R., Shirley, Cynthia R., Amidon, Wendy, Banerjee, Sanjay, ...

Fertility of spermatozoa depends on maintenance of the mitochondrial transmembrane potential (Δψm), which is generated by the electron-transport chain and regulated by an oxidation–reduction...