Colin A. M. Semple

Genome-wide analysis of mammalian promoter architecture and evolution (2006)

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Katayama, Shintaro, Shimokawa, Kazuro, Ponjavic, Jasmina, ...

Mammalian promoters can be separated into two classes, conserved TATA box enriched promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-rich promoters. We have...

Genome-wide analysis of mammalian promoter architecture and evolution (2006)

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Katayama, Shintaro, Shimokawa, Kazuro, Ponjavic, Jasmina, ...

Mammalian promoters can be separated into two classes, conserved TATA box enriched promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-rich promoters. We have...

Genome-wide analysis of mammalian promoter architecture and evolution (2006)

Carninci, Piero, Sandelin, Albin, Lenhard, Boris, Katayama, Shintaro, Shimokawa, Kazuro, Ponjavic, Jasmina, ...

Mammalian promoters can be separated into two classes, conserved TATA box enriched promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-rich promoters. We have...

SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis

Le Hellard, Stéphanie, Ballereau, Stéphane J., Visscher, Peter M., Torrance, Helen S., Pinson, Jeni, Morris, Stewart W., ...

We have compared the accuracy, efficiency and robustness of three methods of genotyping single nucleotide polymorphisms on pooled DNAs. We conclude that (i) the frequencies of the two alleles in...

The Comparative Proteomics of Ubiquitination in Mouse

Semple, Colin A.M.

Ubiquitination is a common posttranslational modification in eukaryotic cells, influencing many fundamental cellular processes. Defects in ubiquitination and the processes it mediates are involved in...

Computational Comparison of Human Genomic Sequence Assemblies for a Region of Chromosome 4

Semple, Colin A.M., Morris, Stewart W., Porteous, David J., Evans, Kathryn L.

Much of the available human genomic sequence data exist in a fragmentary draft state following the completion of the initial high-volume sequencing performed by the International Human Genome...

Heterotachy in Mammalian Promoter Evolution

Taylor, Martin S, Kai, Chikatoshi, Kawai, Jun, Carninci, Piero, Hayashizaki, Yoshihide, Semple, Colin A. M

We have surveyed the evolutionary trends of mammalian promoters and upstream sequences, utilising large sets of experimentally supported transcription start sites (TSSs). With 30,969 well-defined...

Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes

Tiffin, Nicki, Adie, Euan, Turner, Frances, Brunner, Han G., Van Driel, Marc A., Oti, Martin, ...

Genome-wide experimental methods to identify disease genes, such as linkage analysis and association studies, generate increasingly large candidate gene sets for which comprehensive empirical...

SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis

Le Hellard, Stéphanie, Ballereau, Stéphane J., Visscher, Peter M., Torrance, Helen S., Pinson, Jeni, Morris, Stewart W., ...

We have compared the accuracy, efficiency and robustness of three methods of genotyping single nucleotide polymorphisms on pooled DNAs. We conclude that (i) the frequencies of the two alleles in...

Computational Comparison of Human Genomic Sequence Assemblies for a Region of Chromosome 4

Semple, Colin A.M., Morris, Stewart W., Porteous, David J., Evans, Kathryn L.

Much of the available human genomic sequence data exist in a fragmentary draft state following the completion of the initial high-volume sequencing performed by the International Human Genome...

The Comparative Proteomics of Ubiquitination in Mouse

Semple, Colin A.M.

Ubiquitination is a common posttranslational modification in eukaryotic cells, influencing many fundamental cellular processes. Defects in ubiquitination and the processes it mediates are involved in...

Heterotachy in Mammalian Promoter Evolution

Taylor, Martin S, Kai, Chikatoshi, Kawai, Jun, Carninci, Piero, Hayashizaki, Yoshihide, Semple, Colin A. M

We have surveyed the evolutionary trends of mammalian promoters and upstream sequences, utilising large sets of experimentally supported transcription start sites (TSSs). With 30,969 well-defined...

Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes

Tiffin, Nicki, Adie, Euan, Turner, Frances, Brunner, Han G., Van Driel, Marc A., Oti, Martin, ...

Genome-wide experimental methods to identify disease genes, such as linkage analysis and association studies, generate increasingly large candidate gene sets for which comprehensive empirical...