Determination of Stromal Signatures in Breast Carcinoma (2005)
Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...
The authors used two different fibroblastic tumors to identify markers expressed by normal stroma cells (the supporting framework of body tissues and/or tumors), and show that different stromal...
Determination of Stromal Signatures in Breast Carcinoma (2005)
Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...
Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...
Jarvis, Michael A., Wang, C. Edward, Meyers, Heather L., Smith, Patricia P., Corless, Christopher L., Henderson, Gavin J., ...
Epithelial cells are known to be a major target for human cytomegalovirus (HCMV) infection; however, the analysis of virus-cell interactions has been difficult to approach due to the lack of in vitro...
Streblow, Daniel N., Kreklywich, Craig, Yin, Qiang, De La Melena, V. T., Corless, Christopher L., Smith, Patricia A., ...
Cytomegalovirus (CMV) infections have been shown to dramatically affect solid organ transplant graft survival in both human and animal models. Recently, it was demonstrated that rat CMV (RCMV)...
Transplanted human bone marrow contributes to vascular endothelium
Jiang, Shuguang, Walker, Luke, Afentoulis, Michael, Anderson, Daniel A., Jauron-Mills, Linda, Corless, Christopher L., ...
Recent evidence indicates that bone marrow is a source of endothelial progenitor cells that are mobilized into the peripheral blood in response to cytokines or tissue injury. Previously, we showed...
Determination of Stromal Signatures in Breast Carcinoma
West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...
Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...
Han, Gangwen, Lu, Shi-Long, Li, Allen G., He, Wei, Corless, Christopher L., Kulesz-Martin, Molly, ...
In the present study, we demonstrated that human skin cancers frequently overexpress TGF-β1 but exhibit decreased expression of the TGF-β type II receptor (TGF-βRII). To understand how this...
West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...
Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase
Vartanian, Vladimir, Lowell, Brian, Minko, Irina G., Wood, Thomas G., Ceci, Jeffrey D., George, Shakeeta, ...
Endogenously formed reactive oxygen species continuously damage cellular constituents including DNA. These challenges, coupled with exogenous exposure to agents that generate reactive oxygen species,...
Lu, Shi-Long, Herrington, Heather, Reh, Douglas, Weber, Stephen, Bornstein, Sophia, Wang, Donna, ...
The prognosis of head-and-neck squamous cell carcinoma (HNSCC) has not been improved in the past 20 years. Validation of HNSCC biomarkers for targeted therapy has been hindered by a lack of animal...
Jarvis, Michael A., Wang, C. Edward, Meyers, Heather L., Smith, Patricia P., Corless, Christopher L., Henderson, Gavin J., ...
Epithelial cells are known to be a major target for human cytomegalovirus (HCMV) infection; however, the analysis of virus-cell interactions has been difficult to approach due to the lack of in vitro...
Streblow, Daniel N., Kreklywich, Craig, Yin, Qiang, De La Melena, V. T., Corless, Christopher L., Smith, Patricia A., ...
Cytomegalovirus (CMV) infections have been shown to dramatically affect solid organ transplant graft survival in both human and animal models. Recently, it was demonstrated that rat CMV (RCMV)...
Transplanted human bone marrow contributes to vascular endothelium
Jiang, Shuguang, Walker, Luke, Afentoulis, Michael, Anderson, Daniel A., Jauron-Mills, Linda, Corless, Christopher L., ...
Recent evidence indicates that bone marrow is a source of endothelial progenitor cells that are mobilized into the peripheral blood in response to cytokines or tissue injury. Previously, we showed...
Determination of Stromal Signatures in Breast Carcinoma
West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...
Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...
Han, Gangwen, Lu, Shi-Long, Li, Allen G., He, Wei, Corless, Christopher L., Kulesz-Martin, Molly, ...
In the present study, we demonstrated that human skin cancers frequently overexpress TGF-β1 but exhibit decreased expression of the TGF-β type II receptor (TGF-βRII). To understand how this...
West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...
Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase
Vartanian, Vladimir, Lowell, Brian, Minko, Irina G., Wood, Thomas G., Ceci, Jeffrey D., George, Shakeeta, ...
Endogenously formed reactive oxygen species continuously damage cellular constituents including DNA. These challenges, coupled with exogenous exposure to agents that generate reactive oxygen species,...
Lu, Shi-Long, Herrington, Heather, Reh, Douglas, Weber, Stephen, Bornstein, Sophia, Wang, Donna, ...
The prognosis of head-and-neck squamous cell carcinoma (HNSCC) has not been improved in the past 20 years. Validation of HNSCC biomarkers for targeted therapy has been hindered by a lack of animal...
Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach
Coffey, Robert J., Washington, Mary Kay, Corless, Christopher L., Heinrich, Michael C.
Ménétrier disease and gastrointestinal stromal tumors (GISTs) are hyperproliferative disorders of the stomach caused by dysregulated receptor tyrosine kinases (RTKs). In Ménétrier disease,...
KIT Mutations Are Common in Testicular Seminomas
Kemmer, Kathleen, Corless, Christopher L., Fletcher, Jonathan A., McGreevey, Laura, Haley, Andrea, Griffith, Diana, ...
Expression of KIT tyrosine kinase is critical for normal germ cell development and is observed in the majority of seminomas. Activating mutations in KIT are common in gastrointestinal stromal tumors...
West, Robert B., Corless, Christopher L., Chen, Xin, Rubin, Brian P., Subramanian, Subbaya, Montgomery, Kelli, ...
We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs) using cDNA microarrays, and found that the gene FLJ10261 (DOG1, discovered on GIST-1), encoding a...
KIT Gene Mutations in Gastrointestinal Stromal Tumors : More Complex than Previously Recognized?
Fletcher, Jonathan A., Fletcher, Christopher D.M., Rubin, Brian P., Ashman, Leonie K., Corless, Christopher L., Heinrich, Michael C.
Corless, Christopher L., McGreevey, Laura, Haley, Andrea, Town, Ajia, Heinrich, Michael C.
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gut wall that express the receptor tyrosine kinase KIT. Somatic mutations that result in constitutive activation of KIT kinase...
KIT Gene Deletions at the Intron 10−Exon 11 Boundary in GI Stromal Tumors
Corless, Christopher L., McGreevey, Laura, Town, Ajia, Schroeder, Arin, Bainbridge, Troy, Harrell, Patina, ...
Most gastrointestinal stromal tumors (GISTs) harbor oncogenic mutations in the KIT gene, and the majority of these mutations affect the juxtamembrane domain of the kinase encoded by exon 11....
Corless, Christopher L., Harrell, Patina, Lacouture, Mario, Bainbridge, Troy, Le, Claudia, Gatter, Ken, ...
Oncogenic mutations of the receptor tyrosine kinase KIT contribute to the pathogenesis of gastrointestinal stromal tumors, systemic mastocytosis (SM), and some cases of acute myelogenous leukemia...