Christopher D. M. Fletcher

Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. (2005)

Mertens, Fredrik, Fletcher, Christopher D M, Antonescu, Cristina R, Coindre, Jean-Michel, Colecchia, Maurizio, Domanski, Henryk A, ...

Abstract is not available

Activation of the GLI Oncogene through Fusion with the beta-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12). (2004)

Dahlén, Anna, Fletcher, Christopher D M, Mertens, Fredrik, Fletcher, Jonathan A, Perez-Atayde, Antonio R, Hicks, M John, ...

Abstract is not available

The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. (2004)

Panagopoulos, Ioannis, Tiziana Storlazzi, Clelia, Fletcher, Christopher D M, Fletcher, Jonathan A, Nascimento, Antonio, Domanski, Henryk A, ...

Abstract is not available

Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group. (2002)

Mertens, Fredrik, Strömberg, Ulf, Mandahl, Nils, Cin, Paola Dal, De Wever, Ivo, Fletcher, Christopher D M, ...

Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological...

Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. (2002)

Panagopoulos, Ioannis, Mertens, Fredrik, Isaksson, Margareth, Domanski, Henryk A, Brosjö, Otte, Heim, Sverre, ...

Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion...

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

Roberts, Charles W. M., Galusha, Shelly A., McMenamin, Máirín E., Fletcher, Christopher D. M., Orkin, Stuart H.

Malignant rhabdoid tumor (MRT) is an aggressive, highly lethal cancer of young children. Tumors occur in various locations, including kidney, brain, and soft tissues. Despite intensive therapy, 80%...

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

Demetri, George D., Fletcher, Christopher D. M., Mueller, Elisabetta, Sarraf, Pasha, Naujoks, Ryan, Campbell, Natalee, ...

Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-γ have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro....

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...

TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...

Adults With Ewing’s Sarcoma/Primitive Neuroectodermal Tumor: Adverse Effect of Older Age and Primary Extraosseous Disease on Outcome

Baldini, Elizabeth H., Demetri, George D., Fletcher, Christopher D. M., Foran, James, Marcus, Karen C., Singer, Samuel

Response to Chemotherapy and Predictors of Survival in Adult Rhabdomyosarcoma

Esnaola, Nestor F., Rubin, Brian P., Baldini, Elizabeth H., Vasudevan, Naren, Demetri, George D., Fletcher, Christopher D. M., ...

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

Roberts, Charles W. M., Galusha, Shelly A., McMenamin, Máirín E., Fletcher, Christopher D. M., Orkin, Stuart H.

Malignant rhabdoid tumor (MRT) is an aggressive, highly lethal cancer of young children. Tumors occur in various locations, including kidney, brain, and soft tissues. Despite intensive therapy, 80%...

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

Demetri, George D., Fletcher, Christopher D. M., Mueller, Elisabetta, Sarraf, Pasha, Naujoks, Ryan, Campbell, Natalee, ...

Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-γ have been shown to induce terminal differentiation of normal preadipocytes and human liposarcoma cells in vitro....

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...

TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...

Adults With Ewing’s Sarcoma/Primitive Neuroectodermal Tumor: Adverse Effect of Older Age and Primary Extraosseous Disease on Outcome

Baldini, Elizabeth H., Demetri, George D., Fletcher, Christopher D. M., Foran, James, Marcus, Karen C., Singer, Samuel

Response to Chemotherapy and Predictors of Survival in Adult Rhabdomyosarcoma

Esnaola, Nestor F., Rubin, Brian P., Baldini, Elizabeth H., Vasudevan, Naren, Demetri, George D., Fletcher, Christopher D. M., ...

Activation of the GLI Oncogene through Fusion with the β-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12)

Dahlén, Anna, Fletcher, Christopher D. M., Mertens, Fredrik, Fletcher, Jonathan A., Perez-Atayde, Antonio R., Hicks, M. John, ...

Activation of the GLI oncogene is an important step in the sonic hedgehog signaling pathway, and leads to, eg, tissue-specific cell proliferation during embryogenesis. GLI activity in adult tissues...

Expression of the Vascular Endothelial Growth Factor C Receptor VEGFR-3 in Lymphatic Endothelium of the Skin and in Vascular Tumors

Lymboussaki, Athina, Partanen, Taina A., Olofsson, Birgitta, Thomas-Crusells, Judith, Fletcher, Christopher D. M., ...

It is difficult to identify lymph vessels in tissue sections by histochemical staining, and thus a specific marker for lymphatic endothelial cells would be more practical in histopathological...

KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors

Lux, Marcia L., Rubin, Brian P., Biase, Tara L., Chen, Chang-Jie, Maclure, Timothy, Demetri, George, ...

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms arising in the gastrointestinal tract. GISTs express the KIT receptor tyrosine kinase, and many cases have activating...

Correlation between Clinicopathological Features and Karyotype in Spindle Cell Sarcomas : A Report of 130 Cases from the CHAMP Study Group

Fletcher, Christopher D. M., Dal Cin, Paola, De Wever, Ivo, Mandahl, Nils, Mertens, Fredrik, Mitelman, Felix, ...

Soft-tissue tumors have proved to be a fruitful area for the identification of reproducible cytogenetic aberrations, especially among pediatric round-cell sarcomas and lipomatous tumors. Thus far,...

TPM3-ALK and TPM4-ALK Oncogenes in Inflammatory Myofibroblastic Tumors

Lawrence, Brandon, Perez-Atayde, Antonio, Hibbard, Michele K., Rubin, Brian P., Dal Cin, Paola, Pinkus, Jack L., ...

Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal proliferations featuring an inflammatory infiltrate composed primarily of lymphocytes and plasma cells. The myofibroblastic cells...

KIT Gene Mutations in Gastrointestinal Stromal Tumors : More Complex than Previously Recognized?

Fletcher, Jonathan A., Fletcher, Christopher D.M., Rubin, Brian P., Ashman, Leonie K., Corless, Christopher L., Heinrich, Michael C.

Gastrointestinal Stromal Tumours: An Update

Fletcher, Christopher D. M.

Purpose. To study the evolution of concepts concerning gastrointestinal stromal tumours (GISTs) over 30 years.