Christophe Sola

M. tuberculosisgenotypic diversity and drug susceptibility pattern in HIV- infected and non-HIV-infected patients in northern Tanzania (2007)

Kibiki, Gibson S, Mulder, Bert, Dolmans, Wil MV, De Beer, Jessica L, Boeree, Martin, Sam, Noel, ...

Abstract Background Tuberculosis (TB) is a major health problem and HIV is the major cause of the increase in TB. Sub-Saharan Africa is endemic for both TB and HIV infection. Determination of the...

Insights into the evolutionary history of tubercle bacilli as disclosed by genetic rearrangements within a PE_PGRS duplicated gene pair (2006)

Karboul, Anis, Gey Van Pittius, Nicolaas C, Namouchi, Amine, Vincent, Véronique, Sola, Christophe, Rastogi, Nalin, ...

Abstract Background The highly homologous PE_PGRS (Proline-glutamic acid_polymorphic GC-rich repetitive sequence) genes are members of the PE multigene family which is found only in mycobacteria. PE...

Molecular characterisation of Mycobacterium tuberculosisisolates in the First National Survey of Anti-tuberculosis Drug Resistance from Venezuela (2006)

Aristimuño, Liselotte, Armengol, Raimond, Cebollada, Alberto, España, Mercedes, Guilarte, Alexis, Lafoz, Carmen, ...

Abstract Background Molecular typing of Mycobacterium tuberculosis strains has become a valuable tool in the epidemiology of tuberculosis (TB) by allowing detection of outbreaks, tracking of...

Mycobacterium tuberculosiscomplex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology (2006)

Brudey, Karine, Driscoll, Jeffrey R, Rigouts, Leen, Prodinger, Wolfgang M, Gori, Andrea, Al-Hajoj, Sahal A, ...

Abstract Background The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family....

Genotyping of Mycobacterium tuberculosisclinical isolates in two cities of Turkey: Description of a new family of genotypes that is phylogeographically specific for Asia Minor (2005)

Zozio, Thierry, Allix, Caroline, Gunal, Selami, Saribas, Zeynep, Alp, Alpaslan, Durmaz, Riza, ...

Abstract Background Population-based bacterial genetics using repeated DNA loci is an efficient approach to study the biodiversity and phylogeographical structure of human pathogens, such as...

Detection of a Previously Unamplified Spacer within the DR Locus of Mycobacterium tuberculosis: Epidemiological Implications

Filliol, Ingrid, Sola, Christophe, Rastogi, Nalin

Spoligotyping, a method based on the variability of distribution of the 43 inter-direct repeat (DR) spacers of Mycobacterium tuberculosis and Mycobacterium bovis BCG, is useful to study the molecular...

Molecular Typing of Mycobacterium tuberculosis Based on Variable Number of Tandem DNA Repeats Used Alone and in Association with Spoligotyping

Filliol, Ingrid, Ferdinand, Severine, Negroni, Laetitia, Sola, Christophe, Rastogi, Nalin

Fingerprinting based on variable numbers of tandem DNA repeats (VNTR), a recently described methodology, was evaluated for molecular typing of Mycobacterium tuberculosis in an insular setting. In...

Genetic Diversity of Mycobacterium africanum Clinical Isolates Based on IS6110-Restriction Fragment Length Polymorphism Analysis, Spoligotyping, and Variable Number of Tandem DNA Repeats

Viana-Niero, Cristina, Gutierrez, Cristina, Sola, Christophe, Filliol, Ingrid, Boulahbal, Fadila, Vincent, Véronique, ...

A collection of 105 clinical isolates originally identified as Mycobacterium africanum were characterized using both phenotypic and genotyping methods. The phenotypic methods included routine...

Genetic Diversity of Mycobacterium tuberculosis in Sicily Based on Spoligotyping and Variable Number of Tandem DNA Repeats and Comparison with a Spoligotyping Database for Population-Based Analysis

Sola, Christophe, Ferdinand, Severine, Mammina, Caterina, Nastasi, Antonino, Rastogi, Nalin

In a previous study, we proposed to associate spoligotyping and typing with the variable number of tandem DNA repeats (VNTR) as an alternative strategy to IS6110-restriction fragment length...

Use of Spoligotyping To Study the Evolution of the Direct Repeat Locus by IS6110 Transposition in Mycobacterium tuberculosis

Legrand, Eric, Filliol, Ingrid, Sola, Christophe, Rastogi, Nalin

Based on the variability of 43 spacers within the direct repeat (DR) locus of Mycobacterium tuberculosis complex organisms, spoligotyping is a rapid method that aids in the study of the epidemiology...

Rapid Differentiation of “Mycobacterium canettii” from Other Mycobacterium tuberculosis Complex Organisms by PCR-Restriction Analysis of the hsp65 Gene

Goh, Khye Seng, Legrand, Eric, Sola, Christophe, Rastogi, Nalin

A total of 102 isolates of the Mycobacterium tuberculosis complex, including available “M. canettii” isolates, were studied by PCR-restriction analysis of a 441-bp fragment of the hsp65 gene. PRA...

Spoligotyping Followed by Double-Repetitive-Element PCR as Rapid Alternative to IS6110 Fingerprinting for Epidemiological Studies of Tuberculosis

Sola, Christophe, Horgen, Lionel, Maïsetti, Jerome, Devallois, Anne, Goh, Khye Seng, Rastogi, Nalin

A total of 129 clinical isolates of Mycobacterium tuberculosis representing 91 patients were typed by a combination of direct-repeat (DR)-based spoligotyping and an inter-IS6110–PGRS (polymorphic...

Characterization of Mycobacterium tuberculosis Complex DNAs from Egyptian Mummies by Spoligotyping

Zink, Albert R., Sola, Christophe, Reischl, Udo, Grabner, Waltraud, Rastogi, Nalin, Wolf, Hans, ...

Bone and soft tissue samples from 85 ancient Egyptian mummies were analyzed for the presence of ancient Mycobacterium tuberculosis complex DNA (aDNA) and further characterized by spoligotyping. The...

Molecular Characterization and Drug Resistance Patterns of Strains of Mycobacterium tuberculosis Isolated from Patients in an AIDS Counseling Center in Port-au-Prince, Haiti: a 1-Year Study

Ferdinand, Séverine, Sola, Christophe, Verdol, Béatrice, Legrand, Eric, Goh, Khye Seng, Berchel, Mylène, ...

Tuberculosis (TB) is one of the most common opportunistic diseases that appear among human immunodeficiency virus (HIV)-positive patients in Haiti. In this context the probable emergence of...

Evolutionary Relationships among Strains of Mycobacterium tuberculosis with Few Copies of IS6110

Dale, Jeremy W., Al-Ghusein, Hasan, Al-Hashmi, Salim, Butcher, Philip, Dickens, Anne L., Drobniewski, Francis, ...

Molecular typing of Mycobacterium tuberculosis by using IS6110 shows low discrimination when there are fewer than five copies of the insertion sequence. Using a collection of such isolates from a...

Characterization of Finnish Mycobacterium tuberculosis Isolates by Spoligotyping

Puustinen, Kirsi, Marjamäki, Merja, Rastogi, Nalin, Sola, Christophe, Filliol, Ingrid, Ruutu, Petri, ...

The molecular epidemiology of tuberculosis (TB) in Finland was studied by spoligotyping 380 Mycobacterium tuberculosis isolates. The isolates were obtained during a 1-year study period from July 2000...

Snapshot of Moving and Expanding Clones of Mycobacterium tuberculosis and Their Global Distribution Assessed by Spoligotyping in an International Study†

Filliol, Ingrid, Driscoll, Jeffrey R., Van Soolingen, Dick, Kreiswirth, Barry N., Kremer, Kristin, Valétudie, Georges, ...

The present update on the global distribution of Mycobacterium tuberculosis complex spoligotypes provides both the octal and binary descriptions of the spoligotypes for M. tuberculosis complex,...

Genetic Biodiversity of Mycobacterium tuberculosis Complex Strains from Patients with Pulmonary Tuberculosis in Cameroon

Niobe-Eyangoh, Sara Ngo, Kuaban, Christopher, Sorlin, Philippe, Cunin, Patrick, Thonnon, Jocelyn, Sola, Christophe, ...

We analyzed DNA polymorphisms in 455 Mycobacterium tuberculosis complex isolates from 455 patients to evaluate the biodiversity of tubercle bacilli in Ouest province, Cameroon. The phenotypic and...

Molecular Epidemiology of Mycobacterium tuberculosis in Western Sweden

Brudey, Karine, Gordon, Max, Moström, Peter, Svensson, Liselott, Jonsson, Bodil, Sola, Christophe, ...

The genetic diversity of Mycobacterium tuberculosis isolates among patients from Sweden was determined by a combination of two PCR-based techniques (spoligotyping and variable number of tandem...

High Rates of Clustering of Strains Causing Tuberculosis in Harare, Zimbabwe: a Molecular Epidemiological Study

Easterbrook, Philippa J., Gibson, Andrea, Murad, Shahed, Lamprecht, Dianie, Ives, Natalie, Ferguson, Alex, ...

We examined the pattern of tuberculosis (TB) transmission (i.e., reactivation versus recent transmission) and the impact of human immunodeficiency virus (HIV) infection in Harare, Zimbabwe....

Mycobacterium africanum Genotyping Using Novel Spacer Oligonucleotides in the Direct Repeat Locus

Brudey, Karine, Gutierrez, M. Cristina, Vincent, Véronique, Parsons, Linda M., Salfinger, Max, Rastogi, Nalin, ...

This study involves a first evaluation of 25 novel spacer oligonucleotides in addition to the 43 routine spacers for molecular characterization of a panel of 65 isolates of tubercle bacilli from...

Analysis of Mycobacterium tuberculosis Genotypes in Madrid and Identification of Two New Families Specific to Spain-Related Settings

García De Viedma, Darío, Bouza, Emilio, Rastogi, Nalin, Sola, Christophe

In Spain, tuberculosis (TB) patterns are changing because of the recent increase in the number of cases among immigrants. To establish the composition of circulating Mycobacterium tuberculosis...

Genetic Diversity, Determined on the Basis of katG463 and gyrA95 Polymorphisms, Spoligotyping, and IS6110 Typing, of Mycobacterium tuberculosis Complex Isolates from Italy

Lari, Nicoletta, Rindi, Laura, Sola, Christophe, Bonanni, Daniela, Rastogi, Nalin, Tortoli, Enrico, ...

Mycobacterium tuberculosis complex isolates (n = 248) collected during a 1-year period in Tuscany, Italy, were genotyped for the katG463 and gyrA95 polymorphisms and by standard spacer...

Molecular Evolutionary History of Tubercle Bacilli Assessed by Study of the Polymorphic Nucleotide within the Nitrate Reductase (narGHJI) Operon Promoter

Goh, Khye Seng, Rastogi, Nalin, Berchel, Mylène, Huard, Richard C., Sola, Christophe

A well-characterized collection of Mycobacterium tuberculosis complex (MTC) isolates, representing all known subspecies as well as some relevant genotypic families of M. tuberculosis, was analyzed...

Distribution of Strain Families of Mycobacterium tuberculosis Causing Pulmonary and Extrapulmonary Disease in Hospitalized Children in Cape Town, South Africa

Nicol, Mark P., Sola, Christophe, February, Bradley, Rastogi, Nalin, Steyn, Lafras, Wilkinson, Robert J.

We studied the association between strain family and extrapulmonary tuberculosis among 285 children presenting to a pediatric hospital. Extrapulmonary disease occurred in 56% of children without...

Long-Term Population-Based Genotyping Study of Mycobacterium tuberculosis Complex Isolates in the French Departments of the Americas†

Brudey, Karine, Filliol, Ingrid, Ferdinand, Séverine, Guernier, Vanina, Duval, Philippe, Maubert, Bertrand, ...

The three French overseas departments of the Americas are characterized both by insular (Guadeloupe and Martinique) and continental (French Guiana) settings with a tuberculosis case detection rate...

Detection of a Previously Unamplified Spacer within the DR Locus of Mycobacterium tuberculosis: Epidemiological Implications

Filliol, Ingrid, Sola, Christophe, Rastogi, Nalin

Spoligotyping, a method based on the variability of distribution of the 43 inter-direct repeat (DR) spacers of Mycobacterium tuberculosis and Mycobacterium bovis BCG, is useful to study the molecular...

Molecular Typing of Mycobacterium tuberculosis Based on Variable Number of Tandem DNA Repeats Used Alone and in Association with Spoligotyping

Filliol, Ingrid, Ferdinand, Severine, Negroni, Laetitia, Sola, Christophe, Rastogi, Nalin

Fingerprinting based on variable numbers of tandem DNA repeats (VNTR), a recently described methodology, was evaluated for molecular typing of Mycobacterium tuberculosis in an insular setting. In...

Genetic Diversity of Mycobacterium africanum Clinical Isolates Based on IS6110-Restriction Fragment Length Polymorphism Analysis, Spoligotyping, and Variable Number of Tandem DNA Repeats

Viana-Niero, Cristina, Gutierrez, Cristina, Sola, Christophe, Filliol, Ingrid, Boulahbal, Fadila, Vincent, Véronique, ...

A collection of 105 clinical isolates originally identified as Mycobacterium africanum were characterized using both phenotypic and genotyping methods. The phenotypic methods included routine...

Genetic Diversity of Mycobacterium tuberculosis in Sicily Based on Spoligotyping and Variable Number of Tandem DNA Repeats and Comparison with a Spoligotyping Database for Population-Based Analysis

Sola, Christophe, Ferdinand, Severine, Mammina, Caterina, Nastasi, Antonino, Rastogi, Nalin

In a previous study, we proposed to associate spoligotyping and typing with the variable number of tandem DNA repeats (VNTR) as an alternative strategy to IS6110-restriction fragment length...

Use of Spoligotyping To Study the Evolution of the Direct Repeat Locus by IS6110 Transposition in Mycobacterium tuberculosis

Legrand, Eric, Filliol, Ingrid, Sola, Christophe, Rastogi, Nalin

Based on the variability of 43 spacers within the direct repeat (DR) locus of Mycobacterium tuberculosis complex organisms, spoligotyping is a rapid method that aids in the study of the epidemiology...

Rapid Differentiation of “Mycobacterium canettii” from Other Mycobacterium tuberculosis Complex Organisms by PCR-Restriction Analysis of the hsp65 Gene

Goh, Khye Seng, Legrand, Eric, Sola, Christophe, Rastogi, Nalin

A total of 102 isolates of the Mycobacterium tuberculosis complex, including available “M. canettii” isolates, were studied by PCR-restriction analysis of a 441-bp fragment of the hsp65 gene. PRA...

Spoligotyping Followed by Double-Repetitive-Element PCR as Rapid Alternative to IS6110 Fingerprinting for Epidemiological Studies of Tuberculosis

Sola, Christophe, Horgen, Lionel, Maïsetti, Jerome, Devallois, Anne, Goh, Khye Seng, Rastogi, Nalin

A total of 129 clinical isolates of Mycobacterium tuberculosis representing 91 patients were typed by a combination of direct-repeat (DR)-based spoligotyping and an inter-IS6110–PGRS (polymorphic...

Characterization of Mycobacterium tuberculosis Complex DNAs from Egyptian Mummies by Spoligotyping

Zink, Albert R., Sola, Christophe, Reischl, Udo, Grabner, Waltraud, Rastogi, Nalin, Wolf, Hans, ...

Bone and soft tissue samples from 85 ancient Egyptian mummies were analyzed for the presence of ancient Mycobacterium tuberculosis complex DNA (aDNA) and further characterized by spoligotyping. The...

Molecular Characterization and Drug Resistance Patterns of Strains of Mycobacterium tuberculosis Isolated from Patients in an AIDS Counseling Center in Port-au-Prince, Haiti: a 1-Year Study

Ferdinand, Séverine, Sola, Christophe, Verdol, Béatrice, Legrand, Eric, Goh, Khye Seng, Berchel, Mylène, ...

Tuberculosis (TB) is one of the most common opportunistic diseases that appear among human immunodeficiency virus (HIV)-positive patients in Haiti. In this context the probable emergence of...

Evolutionary Relationships among Strains of Mycobacterium tuberculosis with Few Copies of IS6110

Dale, Jeremy W., Al-Ghusein, Hasan, Al-Hashmi, Salim, Butcher, Philip, Dickens, Anne L., Drobniewski, Francis, ...

Molecular typing of Mycobacterium tuberculosis by using IS6110 shows low discrimination when there are fewer than five copies of the insertion sequence. Using a collection of such isolates from a...

Characterization of Finnish Mycobacterium tuberculosis Isolates by Spoligotyping

Puustinen, Kirsi, Marjamäki, Merja, Rastogi, Nalin, Sola, Christophe, Filliol, Ingrid, Ruutu, Petri, ...

The molecular epidemiology of tuberculosis (TB) in Finland was studied by spoligotyping 380 Mycobacterium tuberculosis isolates. The isolates were obtained during a 1-year study period from July 2000...

Snapshot of Moving and Expanding Clones of Mycobacterium tuberculosis and Their Global Distribution Assessed by Spoligotyping in an International Study†

Filliol, Ingrid, Driscoll, Jeffrey R., Van Soolingen, Dick, Kreiswirth, Barry N., Kremer, Kristin, Valétudie, Georges, ...

The present update on the global distribution of Mycobacterium tuberculosis complex spoligotypes provides both the octal and binary descriptions of the spoligotypes for M. tuberculosis complex,...

Genetic Biodiversity of Mycobacterium tuberculosis Complex Strains from Patients with Pulmonary Tuberculosis in Cameroon

Niobe-Eyangoh, Sara Ngo, Kuaban, Christopher, Sorlin, Philippe, Cunin, Patrick, Thonnon, Jocelyn, Sola, Christophe, ...

We analyzed DNA polymorphisms in 455 Mycobacterium tuberculosis complex isolates from 455 patients to evaluate the biodiversity of tubercle bacilli in Ouest province, Cameroon. The phenotypic and...

Molecular Epidemiology of Mycobacterium tuberculosis in Western Sweden

Brudey, Karine, Gordon, Max, Moström, Peter, Svensson, Liselott, Jonsson, Bodil, Sola, Christophe, ...

The genetic diversity of Mycobacterium tuberculosis isolates among patients from Sweden was determined by a combination of two PCR-based techniques (spoligotyping and variable number of tandem...

High Rates of Clustering of Strains Causing Tuberculosis in Harare, Zimbabwe: a Molecular Epidemiological Study

Easterbrook, Philippa J., Gibson, Andrea, Murad, Shahed, Lamprecht, Dianie, Ives, Natalie, Ferguson, Alex, ...

We examined the pattern of tuberculosis (TB) transmission (i.e., reactivation versus recent transmission) and the impact of human immunodeficiency virus (HIV) infection in Harare, Zimbabwe....

Mycobacterium africanum Genotyping Using Novel Spacer Oligonucleotides in the Direct Repeat Locus

Brudey, Karine, Gutierrez, M. Cristina, Vincent, Véronique, Parsons, Linda M., Salfinger, Max, Rastogi, Nalin, ...

This study involves a first evaluation of 25 novel spacer oligonucleotides in addition to the 43 routine spacers for molecular characterization of a panel of 65 isolates of tubercle bacilli from...

Analysis of Mycobacterium tuberculosis Genotypes in Madrid and Identification of Two New Families Specific to Spain-Related Settings

García De Viedma, Darío, Bouza, Emilio, Rastogi, Nalin, Sola, Christophe

In Spain, tuberculosis (TB) patterns are changing because of the recent increase in the number of cases among immigrants. To establish the composition of circulating Mycobacterium tuberculosis...

Genetic Diversity, Determined on the Basis of katG463 and gyrA95 Polymorphisms, Spoligotyping, and IS6110 Typing, of Mycobacterium tuberculosis Complex Isolates from Italy

Lari, Nicoletta, Rindi, Laura, Sola, Christophe, Bonanni, Daniela, Rastogi, Nalin, Tortoli, Enrico, ...

Mycobacterium tuberculosis complex isolates (n = 248) collected during a 1-year period in Tuscany, Italy, were genotyped for the katG463 and gyrA95 polymorphisms and by standard spacer...

Molecular Evolutionary History of Tubercle Bacilli Assessed by Study of the Polymorphic Nucleotide within the Nitrate Reductase (narGHJI) Operon Promoter

Goh, Khye Seng, Rastogi, Nalin, Berchel, Mylène, Huard, Richard C., Sola, Christophe

A well-characterized collection of Mycobacterium tuberculosis complex (MTC) isolates, representing all known subspecies as well as some relevant genotypic families of M. tuberculosis, was analyzed...

Distribution of Strain Families of Mycobacterium tuberculosis Causing Pulmonary and Extrapulmonary Disease in Hospitalized Children in Cape Town, South Africa

Nicol, Mark P., Sola, Christophe, February, Bradley, Rastogi, Nalin, Steyn, Lafras, Wilkinson, Robert J.

We studied the association between strain family and extrapulmonary tuberculosis among 285 children presenting to a pediatric hospital. Extrapulmonary disease occurred in 56% of children without...