Topological challenges to DNA replication: Conformations at the fork
Postow, Lisa, Crisona, Nancy J., Peter, Brian J., Hardy, Christine D., Cozzarelli, Nicholas R.
The unwinding of the parental DNA duplex during replication causes a positive linking number difference, or superhelical strain, to build up around the elongating replication fork. The branching at...
Alteration of Escherichia coli Topoisomerase IV to Novobiocin Resistance
Hardy, Christine D., Cozzarelli, Nicholas R.
DNA gyrase and topoisomerase IV (topo IV) are the two essential type II topoisomerases of Escherichia coli. Gyrase is responsible for maintaining negative supercoiling of the bacterial chromosome,...
Topological domain structure of the Escherichia coli chromosome
Postow, Lisa, Hardy, Christine D., Arsuaga, Javier, Cozzarelli, Nicholas R.
The circular chromosome of Escherichia coli is organized into independently supercoiled loops, or topological domains. We investigated the organization and size of these domains in vivo and in vitro....
Topological challenges to DNA replication: Conformations at the fork
Postow, Lisa, Crisona, Nancy J., Peter, Brian J., Hardy, Christine D., Cozzarelli, Nicholas R.
The unwinding of the parental DNA duplex during replication causes a positive linking number difference, or superhelical strain, to build up around the elongating replication fork. The branching at...
Alteration of Escherichia coli Topoisomerase IV to Novobiocin Resistance
Hardy, Christine D., Cozzarelli, Nicholas R.
DNA gyrase and topoisomerase IV (topo IV) are the two essential type II topoisomerases of Escherichia coli. Gyrase is responsible for maintaining negative supercoiling of the bacterial chromosome,...
Topological domain structure of the Escherichia coli chromosome
Postow, Lisa, Hardy, Christine D., Arsuaga, Javier, Cozzarelli, Nicholas R.
The circular chromosome of Escherichia coli is organized into independently supercoiled loops, or topological domains. We investigated the organization and size of these domains in vivo and in vitro....
Disentangling DNA during replication: a tale of two strands.
Hardy, Christine D, Crisona, Nancy J, Stone, Michael D, Cozzarelli, Nicholas R
The seminal papers by Watson and Crick in 1953 on the structure and function of DNA clearly enunciated the challenge their model presented of how the intertwined strands of DNA are unwound and...