Assemblage et fonction de complexes ARN-protéines (2008)
Les particules ribonucléoprotéiques (ou RNP) sont à la base de nombreuses fonctions cellulaires fondamentales. La formation de ces particules RNP est un processus très complexe qui nécessite de...
Assemblage et fonction de complexes ARN-protéines (2008)
Les particules ribonucléoprotéiques (ou RNP) sont à la base de nombreuses fonctions cellulaires fondamentales. La formation de ces particules RNP est un processus très complexe qui nécessite de...
Assemblage et fonction de complexes ARN-protéines (2008)
Les particules ribonucléoprotéiques (ou RNP) sont à la base de nombreuses fonctions cellulaires fondamentales. La formation de ces particules RNP est un processus très complexe qui nécessite de...
Assemblage et fonction de complexes ARN-protéines (2008)
Les particules ribonucléoprotéiques (ou RNP) sont à la base de nombreuses fonctions cellulaires fondamentales. La formation de ces particules RNP est un processus très complexe qui nécessite de...
Kufel, Joanna, Allmang, Christine, Chanfreau, Guillaume, Petfalski, Elisabeth, Lafontaine, Denis L. J., Tollervey, David
Almost all small eukaryotic RNAs are processed from transiently stabilized 3′-extended forms. A key question is how and why such intermediates are stabilized and how they can then be processed to...
Degradation of ribosomal RNA precursors by the exosome
Allmang, Christine, Mitchell, Philip, Petfalski, Elisabeth, Tollervey, David
The yeast exosome is a complex of 3′→5′ exonucleases involved in RNA processing and degradation. All 11 known components of the exosome are required during 3′ end processing of the 5.8S rRNA....
Kufel, Joanna, Allmang, Christine, Verdone, Loredana, Beggs, Jean D., Tollervey, David
Depletion of any of the five essential proteins Lsm2p to Lsm5p and Lsm8p leads to strong accumulation of all tested unspliced pre-tRNA species, as well as accumulation of 5′ and 3′ unprocessed...
A complex pathway for 3′ processing of the yeast U3 snoRNA
Kufel, Joanna, Allmang, Christine, Verdone, Loredana, Beggs, Jean, Tollervey, David
Mature U3 snoRNA in yeast is generated from the 3′-extended precursors by endonucleolytic cleavage followed by exonucleolytic trimming. These precursors terminate in poly(U) tracts and are normally...
The yeast exosome and human PM–Scl are related complexes of 3′ → 5′ exonucleases
Allmang, Christine, Petfalski, Elisabeth, Podtelejnikov, Alexandre, Mann, Matthias, Tollervey, David, Mitchell, Philip
We previously identified a complex of 3′ → 5′ exoribonucleases, designated the exosome, that is expected to play a major role in diverse RNA processing and degradation pathways. Further...
A Nuclear Surveillance Pathway for mRNAs with Defective Polyadenylation¶
Milligan, Laura, Torchet, Claire, Allmang, Christine, Shipman, Tracey, Tollervey, David
The pap1-5 mutation in poly(A) polymerase causes rapid depletion of mRNAs at restrictive temperatures. Residual mRNAs are polyadenylated, indicating that Pap1-5p retains at least partial activity. In...
Allmang, Christine, Carbon, Philippe, Krol, Alain
Selenoprotein synthesis in eukaryotes requires the selenocysteine insertion sequence (SECIS) RNA, a hairpin in the 3' untranslated region of selenoprotein mRNAs. The SECIS RNA is recognized by the...
Kufel, Joanna, Allmang, Christine, Chanfreau, Guillaume, Petfalski, Elisabeth, Lafontaine, Denis L. J., Tollervey, David
Almost all small eukaryotic RNAs are processed from transiently stabilized 3′-extended forms. A key question is how and why such intermediates are stabilized and how they can then be processed to...
Degradation of ribosomal RNA precursors by the exosome
Allmang, Christine, Mitchell, Philip, Petfalski, Elisabeth, Tollervey, David
The yeast exosome is a complex of 3′→5′ exonucleases involved in RNA processing and degradation. All 11 known components of the exosome are required during 3′ end processing of the 5.8S rRNA....
Kufel, Joanna, Allmang, Christine, Verdone, Loredana, Beggs, Jean D., Tollervey, David
Depletion of any of the five essential proteins Lsm2p to Lsm5p and Lsm8p leads to strong accumulation of all tested unspliced pre-tRNA species, as well as accumulation of 5′ and 3′ unprocessed...
A complex pathway for 3′ processing of the yeast U3 snoRNA
Kufel, Joanna, Allmang, Christine, Verdone, Loredana, Beggs, Jean, Tollervey, David
Mature U3 snoRNA in yeast is generated from the 3′-extended precursors by endonucleolytic cleavage followed by exonucleolytic trimming. These precursors terminate in poly(U) tracts and are normally...
The yeast exosome and human PM–Scl are related complexes of 3′ → 5′ exonucleases
Allmang, Christine, Petfalski, Elisabeth, Podtelejnikov, Alexandre, Mann, Matthias, Tollervey, David, Mitchell, Philip
We previously identified a complex of 3′ → 5′ exoribonucleases, designated the exosome, that is expected to play a major role in diverse RNA processing and degradation pathways. Further...
A Nuclear Surveillance Pathway for mRNAs with Defective Polyadenylation¶
Milligan, Laura, Torchet, Claire, Allmang, Christine, Shipman, Tracey, Tollervey, David
The pap1-5 mutation in poly(A) polymerase causes rapid depletion of mRNAs at restrictive temperatures. Residual mRNAs are polyadenylated, indicating that Pap1-5p retains at least partial activity. In...
Allmang, Christine, Carbon, Philippe, Krol, Alain
Selenoprotein synthesis in eukaryotes requires the selenocysteine insertion sequence (SECIS) RNA, a hairpin in the 3' untranslated region of selenoprotein mRNAs. The SECIS RNA is recognized by the...
The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery
Boulon, Séverine, Marmier-Gourrier, Nathalie, Pradet-Balade, Bérengère, Wurth, Laurence, Verheggen, Céline, Jády, Beáta E., ...
RNA-binding proteins of the L7Ae family are at the heart of many essential ribonucleoproteins (RNPs), including box C/D and H/ACA small nucleolar RNPs, U4 small nuclear RNP, telomerase, and messenger...