Christian J. Wiedermann

Systematic review of randomized clinical trials on the use of hydroxyethyl starch for fluid management in sepsis (2008)

Wiedermann, Christian J

Abstract Background Patients with sepsis typically require large resuscitation volumes, but the optimal type of fluid remains unclear. The aim of this systematic review was to evaluate current...

The genetic study of three population microisolates in South Tyrol (MICROS): study design and epidemiological perspectives (2007)

Pattaro, Cristian, Marroni, Fabio, Riegler, Alice, Mascalzoni, Deborah, Pichler, Irene, Volpato, Claudia B, ...

Abstract Background There is increasing evidence of the important role that small, isolated populations could play in finding genes involved in the etiology of diseases. For historical and political...

Emergency correction of coagulation before major surgery in two elderly patients on oral anticoagulation (2007)

Angelo, Marzia, Gutmann, Bernhard, Adami, Michele, Zagler, Bernd, Zelger, Anton, Pechlaner, Christoph, ...

Abstract Recommendations for urgent reversal of oral anticoagulation with vitamin K 1 antagonists are largely derived from case series employing empirical dosing regimens with vitamin K 1 and...

Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin (2006)

Djanani, Angela, Mosheimer, Birgit, Kaneider, Nicole C, Ross, Christopher R, Ricevuti, Giovanni, Patsch, Josef R, ...

Abstract Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration...

Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis (2006)

Wiedermann, Christian J

Abstract In disseminated intravascular coagulation (DIC) there is extensive crosstalk between activation of inflammation and coagulation. Endogenous anticoagulatory pathways are downregulated by...

A meta-analysis of controlled trials of recombinant human activated protein C therapy in patients with sepsis (2005)

Wiedermann, Christian J, Kaneider, Nicole C

Abstract Background Meta-analysis of two randomised controlled trials in severe sepsis performed with recombinant human activated protein C may provide further insight as to the therapeutic utility...

Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis (2005)

Kountchev, Jordan, Bijuklic, Klaudija, Bellmann, Romuald, Wiedermann, Christian J, Joannidis, Michael

Abstract Introduction In acute disseminated intravascular coagulation, the effect of antithrombin (AT) administration on elevated levels of D-dimer is not well established. In the present study, we...

The limitations of observational studies on the treatment of severe sepsis (2002)

Wiedermann, Christian J

Abstract Observational studies usually agree with randomised, controlled trials. It is a logical fallacy, however, to suggest that agreement in one direction implies prediction in the other...

Inhibition of Human Peripheral Blood Neutrophil Respiratory Burst by Alcohol-Based Venipuncture Site Disinfection

Reinisch, Norbert, Wiedermann, Christian J., Ricevuti, Giovanni

Ethanol inhibits the respiratory burst of neutrophils. Therefore, the effects of alcohol-based skin disinfection on oxygen metabolism in neutrophils were tested using 70% ethanol or an...

The limitations of observational studies on the treatment of severe sepsis

Wiedermann, Christian J

Observational studies usually agree with randomised, controlled trials. It is a logical fallacy, however, to suggest that agreement in one direction implies prediction in the other direction....

Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment

Kaneider, Nicole C., Kaser, Arthur, Dunzendorfer, Stefan, Tilg, Herbert, Wiedermann, Christian J.

The concept that circulating dendritic cells mediate neuroinvasion in transmissible spongiform encephalopathies received strong support from recent observations that prion protein is expressed in...

Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis

Wiedermann, Christian J

In disseminated intravascular coagulation (DIC) there is extensive crosstalk between activation of inflammation and coagulation. Endogenous anticoagulatory pathways are downregulated by inflammation,...

Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin

Djanani, Angela, Mosheimer, Birgit, Kaneider, Nicole C, Ross, Christopher R, Ricevuti, Giovanni, Patsch, Josef R, ...

Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of...

Inhibition of Human Peripheral Blood Neutrophil Respiratory Burst by Alcohol-Based Venipuncture Site Disinfection

Reinisch, Norbert, Wiedermann, Christian J., Ricevuti, Giovanni

Ethanol inhibits the respiratory burst of neutrophils. Therefore, the effects of alcohol-based skin disinfection on oxygen metabolism in neutrophils were tested using 70% ethanol or an...

The limitations of observational studies on the treatment of severe sepsis

Wiedermann, Christian J

Observational studies usually agree with randomised, controlled trials. It is a logical fallacy, however, to suggest that agreement in one direction implies prediction in the other direction....

Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment

Kaneider, Nicole C., Kaser, Arthur, Dunzendorfer, Stefan, Tilg, Herbert, Wiedermann, Christian J.

The concept that circulating dendritic cells mediate neuroinvasion in transmissible spongiform encephalopathies received strong support from recent observations that prion protein is expressed in...

Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis

Wiedermann, Christian J

In disseminated intravascular coagulation (DIC) there is extensive crosstalk between activation of inflammation and coagulation. Endogenous anticoagulatory pathways are downregulated by inflammation,...

Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin

Djanani, Angela, Mosheimer, Birgit, Kaneider, Nicole C, Ross, Christopher R, Ricevuti, Giovanni, Patsch, Josef R, ...

Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of...

Emergency correction of coagulation before major surgery in two elderly patients on oral anticoagulation

Angelo, Marzia, Gutmann, Bernhard, Adami, Michele, Zagler, Bernd, Zelger, Anton, Pechlaner, Christoph, ...

Recommendations for urgent reversal of oral anticoagulation with vitamin K1 antagonists are largely derived from case series employing empirical dosing regimens with vitamin K1 and prothrombin...